第1解剖学 研究業績

 

主な業績

 

1)骨代謝および骨粗鬆症の形態学的解析 (2)咀嚼刺激によるストレス緩和の神経科学的解析

3)計算解剖モデルの構築 に関連する学術論文

Chen H, Zhou X, Washimi Y, Shoumura S.
Three-dimensional microstructure of the bone in a hamster model of senile osteoporosis.
Bone 43:494-500, 2008.

Chen H, Shoumura S, Emura S, Bunai Y.
Regional variations of vertebral trabecular bone microstructure with age and gender.
Osteoporos Int 19:1473-1483, 2008.

Chen H, Zhou X, Emura S, Shoumura S.
Site-specific bone loss in senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis.
Exp Gerontol 44:792-798 , 2009.

Chen H, Shoumura S, Emura S, Isono H.
Tibetan medicated-bath therapy may improve adjuvant arthritis in rat.
Evid Based Complement Alternat Med 6:211-217, 2009.

Chen H, Yano R, Emura S, Shoumura S.

Anatomic variation of the celiac trunk with special reference to hepatic artery patterns.

Ann Anat 191:399-407, 2009.  

Chen H, Zhou X, Shoumura S, Emura S, Bunai Y.
Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neck.
Osteoporos Int 21:627-636, 2010.

Washimi Y, Chen H, Ito A, Takao R, Uzawa T, Yamamoto Y, Yamada H, Shoumura S.
Effect of intermittent treatment with human parathyroid hormone 1-34 in SAMP6 senescence-accelerated mice.
J Endocrinol Invest 33:395-400, 2010.

Ishiguro M, Mishiro K, Fujiwara Y, Chen H, Izuta H, Tsuruma K, Shimazawa M, Yoshimura S, Satoh M, Iwama T, Hara H.

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.

PLoS One 5:e15178, 2010.Chen H, Washimi Y, Kubo K, Onozuka M.
Gender-related changes in three-dimensional microstructure of trabecular bone at the human proximal tibia with aging.
Histol Histopathol 26:563-570, 2011.

Hayashi T, Chen H, Miyamoto K, Zhou X, Hara T, Yokoyama R, Kanematsu M, Hoshi H, Fujita H.
Analysis of bone mineral density distribution at trabecular bones in thoracic and lumbar vertebrae using X-ray CT images.
J Bone Miner Metab 29:174-185, 2011.

Chen H, Kubo K.

Segmental variations in trabecular bone density and microstructure of the spine in senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis.

Exp Gerontol 47:317-322, 2012.

Zhou X, Wang S, Chen H, Hara T, Yokoyama R, Kanematsu M, Fujita H.

Automatic localization of solid organs on 3D CT images by a collaborative majority voting decision based on ensemble learning.

Comput Med Imaging Graph 36:304-313, 2012.

Chen H, Wu M, Kubo K.

Combined treatment with a traditional Chinese medicine, Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) and alendronate improves bone microstructure in ovariectomized rats.

J Ethnopharmacol 142:80-85, 2012.

Chen H, Senda T, Emura S, Kubo K.

An update on the structure of the parathyroid gland.

The open Anatomy Journal 5:1-9, 2013.

Chen H, Zhou X, Fujita H, Onozuka M, Kubo K.

Age-related changes in trabecular and cortical bone microsctructure.

Int J Endocrinol 2013:1-9, 2013.

Chen H, Kubo KY.

Bone three-dimensional microstructural features of the common osteoporotic fracture sites.

World J Orthopedics 5:486-95, 2014.

Iinuma M, Kondo H, Kurahashi M, Ohnishi M, Tamura Y, Chen H, Kubo KY.

Relationship between the early toothless condition and hippocampal functional morphology.

Anat Physiol 4:3, 2014.

Furuzawa M, Chen H, Fujiwara S, Yamada K, Kubo KY.

Chewing ameliorates chronic mild stress-induced bone loss in senescence- accelerated mouse (SAMP8), a murine model of senile osteoporosis.

Exp Gerontol 55:12-18, 2014.

Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Matsumoto M, Chen H, Hida Y, Nakagawa T.

Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.

Biochem Biophys Res Commun 443:1232-8, 2014.

Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H.

Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis.

PLoS One 9:e103818, 2014.

Chen H, Senda T, Kubo KY.

The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.

Med Mol Morphol 48:68, 2015.

Chen H, Iinuma M, Onozuka M, Kubo KY.

Chewing maintains hippocampus-dependent cognitive function.

Int J Med Sci 12:502-509, 2015.

Kubo KY, Iinuma M, Chen H.

Mastication as a stress-coping behavior.

Biomed Res Int 2015:876409, 2015.

Kurahashi M, Kondo H, Iinuma M, Tamura Y, Chen H, Kubo K.

Tooth loss early in life accelerateds age-remlated bone deterioration in mice.

Tohoku J Exp Med 235:29-37, 2015.

Endo S, Nishiyama A, Suyama M, Takemura M, Soda M, Chen H, Tajima K, El-Kabbani O, Bunai Y, Hara A, Matsunaga T, Ikari A.

Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells.

Chem Biol Interact 234:282-289, 2015.

Azuma K, Furuzawa M, Fujiwara S, Yamada K, Kubo KY.

Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice.

Int J Med Sci 12:952-957, 2015

Azuma K, Adachi Y, Hayashi H, Kubo KY.

Chronic Psychological Stress as a Risk Factor of Osteoporosis.

J UOEH 37:245-253, 2015 

Kondo H, Kurahashi M, Mori D, Iinuma M, Tamura Y, Mizutani K, Shimpo K, Sonoda S, Azuma K, Kuno KY.

Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment.

Arch Oral Biol 61:1-7, 2016

Miyake H, Mori D, Katayama T, Fujiwara S, Sato Y, Azuma K, Kubo KY.

Novel stress increases hypothalamic-pituitary-adrenal activity in mice with a raised bite.

Arch Oral Biol 68:55-60, 2016.

Ueda M, Li S, Itoh M, Wang MX, Hayakawa M, Islam S, Tana, Nakagawa K, Chen H, Nakagawa T.

Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion.

Biochem Biophys Res Commun 474:259-63, 2016.

Suzuki A, Iinuma M, Hayashi S, Sato Y, Azuma K, Kubo KY.

Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring.

Brain Res 1651:36-43, 2016.

Kubo KY, Murabayashi C, Kotachi M, Suzuki A, Mori D, Sato Y, Onozuka M, Azuma K, Iinuma M.

Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice.

Arch Oral Biol 74: 21-27, 2017.

Azuma K, Ogura M, Kondo H, Suzuki A, Hayashi S, Iinuma M, Onozuka M, Kubo KY.

Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring.

Int J Med Sci 14:348-355, 2017

 

 

4)脂肪酸結合タンパク質(FABP)の発現解析 (5)免疫組織を中心にしたFABPの機能探索 に関連する学術論文

Tokuda N., Adachi T., Adachi Y., Higashi M., Sharifi K., Tuerxun T., Sawada T., Kondo H., Owada Y.

Identification of FABP7 in fibroblastic reticular cells of mouse lymphnodes.

Histochem Cell Biol 134: 445-452, 2010.

Ogawa E., Owada Y., Ikawa S., Adachi Y., Egawa T., Nemoto K., Suzuki K., Hishinuma T., Kawashima H., Kondoh H., Muto M., Aiba S., Okuyama R.

Epidermal FABP (FABP5) regulates keratinocyte differentiation via 13(S)-HODE mediated activation of the NF-kB signaling pathway.

J Invest Dermatol 131,604-612, 2011.

Sharifi, K., Morihiro, Y., Maekawa, M., Yasumoto, Y., Hoshi, H., Adachi, Y., Sawada, T., Tokuda, N., Kondo, H., Yoshikawa, T., Suzuki, M. and Owada, Y.

FABP7 expression in normal and stab injured brain cortex and its role in astrocyte proliferation.

Histochem Cell Biol 136, 501-13, 2011.

Adachi Y., Hiramatsu S., Tokuda N., Sharifi K., Ebrahimi M., Islam A., Kagawa Y., Koshy L. V., Sawada T., Hamano K. and Owada Y.

Fatty acid-binding protein (FABP) 4 and FABP5 modulate cytokine production in the mouse thymic epithelial cells.

Histochem Cell Biol 138: 397-406, 2012.

Sugawara T., Nemoto K., Tokuda N., Adachi Y., Yamano N., Muto M., Okuyama R., Sakai S. and Owada Y.

Reduced size of sebaceous gland and altered sebum lipid composition in mice deficient in the fatty acid-binding protein 5 gene.

Exp Dermatol 21: 535-561, 2012.

Kizuka, F., Tokuda, N., Takagi, K., Adachi, Y., Lee, L, Tamura, I., Maekawa, R., Taketani, T., Tamura, H., Suzuki, T., Owada, Y. and Sugino, N.

Involvement of bone marrow-derived vascular progenitor cells in neovascularization during the corpus luteum formation in mice.

Biol Reprod 87:1-7, 2012

Inamura A., Adachi Y., Inoue T., He Y., Tokuda N., Nawata T., Shirao S., Nomura S., Fujii M., Ikeda E., Owada Y. and Suzuki M.

Cooling treatment transiently increases the permeabillity of brain capillary endotherial cells through translocation of Claudin-5.

Neurochem Res 38: 1641-1647,2013.

Kizuka-Shibuya F., Tokuda N., Takagi K.,Adachi Y., Lee L, Tamura I., Maekawa R., Tamura H., Suzuki T., Owada Y. and Sugino N.

Locally existing endotherial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice.

J Ovarian Res 7: 10, 2014.

Miyazaki H., Sawada T., Kiyohira M., Yu Z., Nakamura K., Yasumoto Y., Kagawa Y., Ebrahimi M., Islam A., Sharifi K., Kawamura S., Kodama T., Yamamoto Y., Adachi Y., Tokuda N., Terai S., Sakaida I., Ishikawa T., Owada Y.

Fatty acid binding protein 7 regulates phagocytosis and cytokine production in kupffer cells during liver injury.

Am J Pathol 184: 2505-2515, 2014.

Shibue K., Yamane S., Harada N., Suzuki K., Joo E., Iwasaki K., Nasteska D., Harada T., Hayashi Y., Adachi Y., Owada Y., Takayanagi R., Inagaki N.

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Am J Physiol Endocrinol Metab 308(7): E583-91, 2015.

 

6)リンパ組織の構造と機能 に関連する学術論文

Kakeda S, Korogi Y, Yoneda T, Nishimura J, Sato T, Hiai Y, Ohnari N, Okada K, Hayashi H, Matsusue E, Uozumi T, Tsuji S.

A novel tract imaging technique of the brainstem using phase difference enhanced imaging: normal anatomy and initial experience in multiple system atrophy.

Eur Radiol 21: 2202-2210, 2011.

 

著 書

林 春樹,菊田彰夫.

リンパ節細網とリンパの流れ.

メディカルバイオ,株式会社オーム社:58-622008.

陳 華岳, 正村静子.

骨の疾患:骨の加齢変化と骨粗鬆症.

病気の分子形態学, 日本臨床分子形態学会,学際企画株式会社: 251-253, 2011.

Chen H, Kubo K, Onozuka M, Hayashi T, Zhou X, Fujita H.
Sophisticated imaging technology in the assessment of osteoporosis risk.
Osteoporosis, Dionyssiotis Y ed, InTech Open Access Publisher, p181-194, 2012.

Parathyroid gland, skeletal muscle, tendon and periosteum in SAMP6.

The senescence-accelerated mouse (SAM):Achievements and future directions,

Takeda T ed, Elsevier: p85-94, 2013.

千田隆夫,陳 華岳,清水洋二.

免疫組織化学の原理と基礎.

組織細胞化学, 日本組織細胞化学会編,学際企画株式会社: 1-16頁,2013.

Kubo KY, Chen H, Onozuka M.

The relationship between mastication and cognition.

Senescence and senescence-related disorders,

Wang Z and Inuzuka H eds, InTech Open Access Publisher: p115-132, 2013.

Hayashi T, Chen H, Miyamoto K, Zhou X, Hara T, Fujita H.

Computer-aided image analysis for vertebral anatomy on X-ray CT images.

Computational Intelligence in Biomedical Imaging,

Suzuki K ed, Springer: p159-184, 2014.

 

 

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