准教授
森本 景之 〔博士（歯学）〕
キーワード
２本鎖RNA依存性プロテインキナーゼ（PKR），アポトーシス，タンパク質相互作用
研究業績
1. Haneji T, Morimoto H, Morimoto Y, Shirakawa S, Kobayashi S, Kaneda C, Shima H and Nagao M: Subcellular localization of protein phosphatase type 1 isotypes in mouse osteoblastic cells. Biochemical and Biophysical Research Communications 248, 39-43, 1998.
2. Morimoto Y, Morimoto H, Kobayashi S, Ohba T and Haneji T: Extracts of Actinobacillus actinomycetemcomitans induce apoptotic cell death in human osteoblastic MG63 cells. Journal of Dental Research 78, 735-742, 1999.
4. Morimoto H, Morimoto Y, Kido H, Kobayashi S, Ohba T and Haneji T: Inhibitors of protein synthesis and RNA synthesis protect against okadaic acid-induced apoptosis in human osteosarcoma cell line MG63 cells but not in Saos-2 cells. Journal of Bone and Mineral Metabolism 17 (4), 266-273, 1999.
5. 森本景之：骨芽細胞と蛋白質脱リン酸化酵素１型 -核小体でのr-RNA合成に関して-．九州歯科学会雑誌，54, 443-455, 2000.
6. Morimoto H, Okamura H and Haneji T: Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells. The Journal of Histochemistry and Cytochemistry 50 (9), 1187-1193, 2002.
7. Kito S, Shimizu K, Okamura H, Yoshida K, Fujita M, Morimoto H, Morimoto Y, Ohba T, Haneji T: Cleavage of nucleolin and argyrophilic nucleolar organizer region associated proteins in apoptosis-induced cells. Biochemical and Biophysical Research Communications 300 (4), 950-956, 2003.
8. Yamashita K, Dennid, JE, Lennon DP, Morimoto H, Kitamura S, Caplan A: Dental pulp cells with multi-potential for differentiation to odontoblast and chondroblast. Journal of Hard Tissue Biology 12, 49-55, 2003.
9. 北村清一郎，尾崎正幸，森本景之 ：鼻呼吸と口呼吸について−解剖・生理学的な見地から−．小児歯科臨床，8 (10), 20-25, 2003.
10. Morimoto H: Type 1 protein phosphatase controls biological processes in cultured human osteoblastic cells. Journal of Oral Biosciences, 46 (4), 270-277, 2004.
11. Morimoto H, Okamura H, Yoshida K, Kitamura S and Haneji T: Double-stranded RNA mediates selective gene silencing of protein phosphatase type 1 delta isoform in HEK-293 cells. Journal of Enzyme Inhibition & Medical Chemistry 19, 327-331, 2004.
12. Morimoto H, Okamura H, Yoshida K, Kitamura S and Haneji T: Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2α pathway in human osteoblastic MG63 cells. Journal of Biochemistry 136, 433-438, 2004.
13. Morimoto H, Ozaki A, Okamura H, Yoshida K, Kitamura S and Haneji T: Okadaic acid induces tyrosine phosphorylation of IκBα that mediated by PKR pathway in human osteoblastic MG63 cells. Molecullar and Cellular Biochemistry 276, 211-217, 2005.
14. Yoshida K, Okamura H, Amorim BR, Ozaki A, Tanaka H, Morimoto H and Haneji T: Double-stranded RNA-dependent protein kinase is required for bone calcification in MC3T3-E1 cells in vitro. Experimental Cell Research 311, 117-125, 2005.
15. 手島理絵，角田佳折，森本景之，北村清一郎：歯科偶発症としての縦郭気腫−空気の波及径路についての解剖学的考察−．解剖学雑誌，80, 73-74, 2005.
16. Ozaki A, Morimoto H, Tanaka H, Okamura H, Yoshida K, Amorim BR, Haneji T: Okadaic acid induces phosphorylation of p65NF-?B on serine 536 and activates NF-κB transcriptional activity in human osteoblastic MG63 cells. Journal of Cellular Biochemistry, 99 (5), 1275-1284, 2006.
17. Morimoto H, Ozaki A, Okamura H, Yoshida K, Amorim BR, Tanaka H, Kitamura S, Haneji T: Differential expression of protein phosphatase type 1 isotypes and nucleolin during cell-cycle arrest, Cell Biochemistry and Function, 25 (4), 369-375, 2007.
18. Amorim BR, Okamura H, Yoshida K, Qiu LH, Morimoto H, Haneji T: The transcriptional factor Osterix directly interacts with RNA helicase A. Biochemical and Biophysical Research Communications, 355 (2), 347-351, 2007.
19. Akita K, Okamura H, Yoshida K, Morimoto H, Ogawa-Iyehara H, Haneji T: Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by bcl-2 expression in human submandibular gland HSG cells. International Journal of Oncology, 31 (4), 923-929, 2007.
20. Sato N, Morimoto H, Baba R, Nakamata J, Doi Y, Yamaguchi K. Functional expression of double-stranded RNA-dependent protein kinase in rat intestinal epithelial cells. Journal of Cellular Biochemistry, 110 (1), 104-111, 2010.
21. Teramachi J, Morimoto H, Baba R, Doi Y, Hirashima K, Haneji T: Double stranded RNA-dependent protein kinase is involved in osteoclast differentiation of RAW 264.7. Experiment Cell Research, 316 (19), 3254-3262, 2010.
22. 森本景之、土肥良秋、藤本 淳：第1章6．細胞傷害「化学物質による細胞毒性」．In：病気の分子形態学、日本臨床分子形態学会（編）、学際企画、東京、pp．26-28，2011.
学会活動
日本解剖学会，日本顕微鏡学会，日本臨床分子形態学会，歯科基礎医学会，Cell Death学会，九州歯科学会，分子病理学研究会
更新日：２０１２年２月８日
文責：第２解剖学講座