Department of Anatomy and Histology
Professor: Yoshiaki Doi (MD, Ph.D.)
Associate Professor. Hiroyuki Morimoto (DDS, Ph.D.)
Assistant Professor: Ryoko Baba (Ph.D.)
Focus of research
1. Analyses on vasoactive substances of endothelial cells
2. Analyses on roles of Weibel-Palade bodies in local blood flow regulation
3. Analyses on glutathion S-transferase of taste buds and olfactory epithelia by immunocytochemistry and in situ hybridization
Key Words
Endothelial cell, Blood flow regulation, Weibel-Palade body, Glutathion S-transferase, Immunocytochemistry, In situ hybridization
Latest publications of our research
1. Fujimoto, S., Doi, Y., Fukushige, H., Kudo, H. & Nishino, T.: Roles of endothelin-1 in regulation of rat hepatic sinusoidal blood flow. In: European Conference on Microcirculation, Fagrell, B. (ed.), Monduzzi Editore, Bologna, pp. 33-37, 2000.
2. Kudo, H., Doi, Y., Nishino, T., Nara, S., Hamasaki, K. & Fujimoto, S.: Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium. J. Nutr., 130 (1): 38-44, 2000.
3. Doi, Y., Peng, H., Kudo, H., Hamasaki, K. & Fujimoto, S.: Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine. Neurosci. Lett., 285 (1): 33-36, 2000.
4. Uchida, S., Doi, Y., Kudo, H., Furukawa, H., Nakamura, T. & Fujimoto, S.: Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury. Bone, 27 (1): 81-90, 2000.
5. Fukushige, H., Doi, Y., Kudo, H., Kayashima, K., Kiyonaga, H., Nagata, T., Itoh, H. & Fujimoto, S.: Synthesis and receptor sites of endothelin-1 in the rat liver vasculature. Anat. Rec., 259 (4): 437-445, 2000.
6. Doi, Y., Kudo, H., Nara, S., Nishino, T. & Fujimoto, S.: Vasocontraction in the rat superior mesenteric artery induced by hypoxia. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 323-327, 2001.
7. Fujimoto, S., Doi, Y., Kudo, H. & Nshino, T.: Vasculogenesis during organogenesis and wound healing. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 347-351, 2001.
8. Nishino, T., Kudo, H., Doi, Y., Maeda, M., Hamasaki, K., Morita, M. & Fujimoto, S.: Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae. Chem. Senses, 26 (2): 179-188, 2001.
9. Kiyonaga, H., Doi, Y., Karasaki, Y., Arashidani, K., Itoh, H. & Fujimoto, S.: Expressions of endothelin-1, fibronectin and interleukin-1a of human umbilical vein endothelial cells under prolonged culture. Med. Ele. Microsc., 34 (1): 41-53, 2001.
10. Kudo, H., Doi, Y. & Fujimoto, S.: Expression of glutathione S-transferase in bisphenol A-treated rat liver. Environ. Sci., 8 (2 & 3): 256, 2001.
11. Doi, Y., Kudo, H., Nishino, T., Kayashima, K., Kiyonaga, H., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells. Histol. Histopathol., 16 (4): 1073-1079, 2001.
12. Doi, Y., Kudo, H., Nishino, T., Yamamoto, O., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Histol. Histopathol., 17 (1): 97-105, 2002.
13. Nara, S., Hachisuka, K., Furukawa, H., Doi, Y., Kudo, H. & Fujimoto, S.: Disorganization of honey-comb immunoreactive pattern of desmin and plectin ｉn rat atrophic soleus muscle fiber induced by hindlimb suspension. Histol. Histopathol., 17 (2): 427-436, 2002.
14. Doi, Y., Kudo, H., Yamamoto, O., Hamasaki, K., Yoshizuka, M. & Fujimoto, S.: Enhancement of immunoreactivity for endothelin-1 and endothelin-converting enzyme-1 in the cadmium-treated rat thoracic aorta. Virchows Arch., 441 (2): 179-186, 2002.
15. Morita, M., Kudo, H., Doi, Y., Hirano, T., Ikemura, K. & Fujimoto, S.: Enhanced immunocytochemical expression of antioxidant enzymes in rat submandibular gland after normobaric oxygenation. Anat. Rec., 268 (4): 371-380, 2002.
16. Uchida, S., Sakai, A., Kudo, H., Otomo, H., Watanuki, M., Tanaka, M., Nagashima, M. & Nakamura, T.: Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats. Bone, 32 (5): 491-501, 2003.
17. Doi, Y., Kudo, H., Nishino, T. & Fujimoto, S.: Vasculogenesis and angiogenesis. J. UOEH, 25 (4): 409-417, 2003.
18. Hirano, T., Kudo, H., Doi, Y., Nishino, T., Fujimoto, S., Tsurudome, Y., Ootsuyama, Y. & Kasai, H.: Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liver. Cancer Science , 95 (2): 118-122, 2004.
19. Doi, Y., Kudo, H., Nishino, T., Kiyonaga, H., Nagata, T., Hamasaki, K. & Fujimoto, S.: The enhancement of endothelin-1 synthesis and processing in the acute hypoxic rat aorta. Proceedings of the 8th Asia-Pacific Conference on Electron Microscopy (8APEM), Tanaka, N., Takano, Y., Mori, H., Seguchi, H., Iseki, S., Shimada, H. & Simamura, E. (eds.), pp. 933-934, 2004.
20. Nagata, T., Kudo, H., Nishino,T., Doi, Y., Itoh, H. & Fujimoto, S.: Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Med. Mol. Morphol., 38 (3): 161-172, 2005.
Educational activities
1. Cytology and histology
2. Angiology
3. Esthesiology
4. Splanchnology
5. Human embryology