intro_e

Focus of research

1. Analyses on vasoactive substances of endothelial cells

2. Analyses on roles of Weibel-Palade bodies in local blood flow regulation

3. Analyses on glutathion S-transferase of taste buds and olfactory epithelia by immunocytochemistry and in situ hybridization

Key Words

Endothelial cell, Blood flow regulation, Weibel-Palade body, Glutathion S-transferase, Immunocytochemistry, In situ hybridization

1. Fujimoto, S., Doi, Y., Fukushige, H., Kudo, H. & Nishino, T.: Roles of endothelin-1 in regulation of rat hepatic sinusoidal blood flow. In: European Conference on Microcirculation, Fagrell, B. (ed.), Monduzzi Editore, Bologna, pp. 33-37, 2000.

2. Kudo, H., Doi, Y., Nishino, T., Nara, S., Hamasaki, K. & Fujimoto, S.: Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium. J. Nutr., 130 (1): 38-44, 2000.

3. Doi, Y., Peng, H., Kudo, H., Hamasaki, K. & Fujimoto, S.: Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine. Neurosci. Lett., 285 (1): 33-36, 2000.

4. Uchida, S., Doi, Y., Kudo, H., Furukawa, H., Nakamura, T. & Fujimoto, S.: Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury. Bone, 27 (1): 81-90, 2000.

5. Fukushige, H., Doi, Y., Kudo, H., Kayashima, K., Kiyonaga, H., Nagata, T., Itoh, H. & Fujimoto, S.: Synthesis and receptor sites of endothelin-1 in the rat liver vasculature. Anat. Rec., 259 (4): 437-445, 2000.

6. Doi, Y., Kudo, H., Nara, S., Nishino, T. & Fujimoto, S.: Vasocontraction in the rat superior mesenteric artery induced by hypoxia. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 323-327, 2001.

7. Fujimoto, S., Doi, Y., Kudo, H. & Nshino, T.: Vasculogenesis during organogenesis and wound healing. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 347-351, 2001.

8. Nishino, T., Kudo, H., Doi, Y., Maeda, M., Hamasaki, K., Morita, M. & Fujimoto, S.: Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae. Chem. Senses, 26 (2): 179-188, 2001.

9. Kiyonaga, H., Doi, Y., Karasaki, Y., Arashidani, K., Itoh, H. & Fujimoto, S.: Expressions of endothelin-1, fibronectin and interleukin-1a of human umbilical vein endothelial cells under prolonged culture. Med. Ele. Microsc., 34 (1): 41-53, 2001.

10. Kudo, H., Doi, Y. & Fujimoto, S.: Expression of glutathione S-transferase in bisphenol A-treated rat liver. Environ. Sci., 8 (2 & 3): 256, 2001.

11. Doi, Y., Kudo, H., Nishino, T., Kayashima, K., Kiyonaga, H., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells. Histol. Histopathol., 16 (4): 1073-1079, 2001.

12. Doi, Y., Kudo, H., Nishino, T., Yamamoto, O., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Histol. Histopathol., 17 (1): 97-105, 2002.

13. Nara, S., Hachisuka, K., Furukawa, H., Doi, Y., Kudo, H. & Fujimoto, S.: Disorganization of honey-comb immunoreactive pattern of desmin and plectin ｉn rat atrophic soleus muscle fiber induced by hindlimb suspension. Histol. Histopathol., 17 (2): 427-436, 2002.

14. Doi, Y., Kudo, H., Yamamoto, O., Hamasaki, K., Yoshizuka, M. & Fujimoto, S.: Enhancement of immunoreactivity for endothelin-1 and endothelin-converting enzyme-1 in the cadmium-treated rat thoracic aorta. Virchows Arch., 441 (2): 179-186, 2002.

15. Morita, M., Kudo, H., Doi, Y., Hirano, T., Ikemura, K. & Fujimoto, S.: Enhanced immunocytochemical expression of antioxidant enzymes in rat submandibular gland after normobaric oxygenation. Anat. Rec., 268 (4): 371-380, 2002.

16. Uchida, S., Sakai, A., Kudo, H., Otomo, H., Watanuki, M., Tanaka, M., Nagashima, M. & Nakamura, T.: Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats. Bone, 32 (5): 491-501, 2003.

17. Doi, Y., Kudo, H., Nishino, T. & Fujimoto, S.: Vasculogenesis and angiogenesis. J. UOEH, 25 (4): 409-417, 2003.

18. Hirano, T., Kudo, H., Doi, Y., Nishino, T., Fujimoto, S., Tsurudome, Y., Ootsuyama, Y. & Kasai, H.: Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liver. Cancer Science , 95 (2): 118-122, 2004.

19. Doi, Y., Kudo, H., Nishino, T., Kiyonaga, H., Nagata, T., Hamasaki, K. & Fujimoto, S.: The enhancement of endothelin-1 synthesis and processing in the acute hypoxic rat aorta. Proceedings of the 8th Asia-Pacific Conference on Electron Microscopy (8APEM), Tanaka, N., Takano, Y., Mori, H., Seguchi, H., Iseki, S., Shimada, H. & Simamura, E. (eds.), pp. 933-934, 2004.

20. Nagata, T., Kudo, H., Nishino,T., Doi, Y., Itoh, H. & Fujimoto, S.: Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Med. Mol. Morphol., 38 (3): 161-172, 2005.

21. Fujimura, T., Suzuki, H., Shimizu, T., Tokui, N., Kitamura, T., Udaka, T. & Doi, Y.: Pathological alterations of strial capillaries in dominant white spotting W/Wv mice. Hear. Res., 209 (1-2), 53-59, 2005.

22. Shiraishi, M., Doi, Y., Kayashima, K. & Fujimoto, S.: Antioxidant enzyme immunoreactivity in rat von Ebner gland after nickel treatment. Med. Mol. Morphol., 41 (1): 44-52, 2008

23. Fujimura, T., Suzuki, H., Udaka, T., Shiomori, T., Mori, T., Inaba, T., Hiraki, N., Kayashima, K. & Doi, Y.: Immunoreactivities for glutathione S-transferases and glutathione peroxidase in the lateral wall of pigmented and albino guinea pig cochlea. Med. Mol. Morphol., 41 (3): 139-144, 2008.

24. Matsuoka, H., Harada, K., Endo, Y., Warashina, A., Doi, Y., Nakamura, J. & Inoue, M.: Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells. J. Physiol., 586 (Pt 20): 4825-4842, 2008

25. Kudo, H., Doi, Y., Ueda, H. & Kaeriyama, M.: Molecular characterization and histochemical demonstration of salmon olfactory marker protein in the olfactory epithelium of lacustrine sockeye salmon (Oncorhynchus nerka). Comp. Biochem. Physiol. A Mol. Inteqr. Physiol., 154 (1): 142-150, 2009.

26. Kudo, H., Doi, Y., & Fujimoto, S.: Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium: A possible role in the phase Ⅲ xenobiotic metabolizing function. Neurosci. Lett., 468 (2): 98-101, 2010.

27. Miyamoto, T., Tamura, M., Kabashima, N., Serino, R., Shibata, T., Furuno, Y., Miyazaki, M., Baba, R., Sato, N., Doi, Y., Okazaki, M. & Otsuji, Y.: An integrin-ａｃｔｉｖａｔｉｎｇ peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. Nephrol. Dial. Transplant., 25 (4): 1109-1119, 2010.

28. Sato, N., Morimoto, H., Baba, R., Nakamata, J., Doi, Y. & Yamaguchi, K.: Functional expression of double-stranded RNA-dependent protein kinase in rat intestinal epithelial cells. J. Cell Biochem., 110 (1): 104-111, 2010.

29. Asahi, J., Kamo, H., Baba, R., Doi, Y., Yamashita, A., Murakami, D., Hanada, A. & Hirano, T.: Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes. Life Sci., 87 (13-14): 431-438, 2010.

Educational activities

　　　　　1. Cytology and histology

　　　　　2. Angiology

　　　　　3. Esthesiology

　　　　　4. Splanchnology