第2解剖学講座

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◆2011年度 電子顕微鏡技術認定試験のお知らせ◆

下記により開催しますので、多数ご参加ください。二級技師は電子顕微鏡の実務経験 がなくても受験できます。

日  時:平成23年10月8日(土)(申込受付期間は9月1日〜15日)

場  所:大学本館2号館2208講義室 実施内容:二級技師および一級技師の筆記試験(一級技師は実技試験が後日あります)

受験料:二級技師8,000円(学生5,000円)、一級技師10,000円(筆記試験の料金)

主  催:社団法人日本顕微鏡学会(詳しくは下記リンク先をご覧下さい。)

電子顕微鏡技術認定試験

連絡先:第2解剖学 土肥良秋(内2286)


研究者

     教 授: 土肥 良秋(博士(医学))

     准教授: 森本 景之(博士(歯学))

     講 師: 馬場 良子(博士(理学))


研究内容

1.血管内皮細胞由来の生理活性物質の解析

2.ワイベル・パラーデ小体が局所血流調節に果たす役割の解析

3.味蕾および嗅上皮におけるグルタチオン−トランスフェラーゼの免疫細胞化学と分子細胞化学


研究内容のキーワード

血管内皮細胞、血流調節、ワイベル・パラーデ小体、グルタチオン−トランスフェラーゼ、免疫細胞化学、分子細胞化学


最近の研究業績

1. Doi, Y., Peng, H., Kudo, H., Hamasaki, K. & Fujimoto, S.: Expression of a-calcitonin gene-related peptide in the enteric nervous system of rat small intestine. Neurosci. Lett., 285 (1): 33-36, 2000.

2. Uchida, S., Doi, Y., Kudo, H., Furukawa, H., Nakamura, T. & Fujimoto, S.: Transient expression of activin bA mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury. Bone, 27 (1): 81-90, 2000.

3. Fukushige, H., Doi, Y., Kudo, H., Kayashima, K., Kiyonaga, H., Nagata, T., Itoh, H. & Fujimoto, S.: Synthesis and receptor sites of endothelin-1 in the rat liver vasculature. Anat. Rec., 259 (4): 437-445, 2000.

4. Doi, Y., Kudo, H., Nara, S., Nishino, T. & Fujimoto, S.: Vasocontraction in the rat superior mesenteric artery induced by hypoxia. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 323-327, 2001.

5. Fujimoto, S., Doi, Y., Kudo, H. & Nshino, T.: Vasculogenesis during organogenesis and wound healing. In: 7th World Congress for Microcirculation, Monduzzi Editore, Bologna, pp. 347-351, 2001.

6. Nishino, T., Kudo, H., Doi, Y., Maeda, M., Hamasaki, K., Morita, M. & Fujimoto, S.: Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae. Chem. Senses, 26 (2): 179-188, 2001.

7. Kiyonaga, H., Doi, Y., Karasaki, Y., Arashidani, K., Itoh, H. & Fujimoto, S.: Expressions of endothelin-1, fibronectin and interleukin-1a of human umbilical vein endothelial cells under prolonged culture. Med. Ele. Microsc., 34 (1): 41-53, 2001.

8. Kudo, H., Doi, Y. & Fujimoto, S.: Expression of glutathione S-transferase in bisphenol A-treated rat liver. Environ. Sci., 8 (2 & 3): 256, 2001.

9. Doi, Y., Kudo, H., Nishino, T., Kayashima, K., Kiyonaga, H., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells. Histol. Histopathol., 16 (4): 1073-1079, 2001.

10. 藤本 淳,土肥良秋:総論K.病気の形態学総論「6.毒物による細胞障害」.pp. 74-76.各論M.神経・血管の疾患「9.血管の構造と機能−その病態生理を含めて−」.pp. 151-153.病気の形態学,日本臨床電子顕微鏡学会編,学際企画,東京,2002.

11. Doi, Y., Kudo, H., Nishino, T., Yamamoto, O., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Histol. Histopathol., 17 (1): 97-105, 2002.

12. Nara, S., Hachisuka, K., Furukawa, H., Doi, Y., Kudo, H. & Fujimoto, S.: Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension. Histol. Histopathol., 17 (2): 427-436, 2002.

13. Doi, Y., Kudo, H., Yamamoto, O., Hamasaki, K., Yoshizuka, M. & Fujimoto, S.: Enhancement of immunoreactivity for endothelin-1 and endothelin-converting enzyme-1 in the cadmium-treated rat thoracic aorta. Virchows Arch., 441 (2): 179-186, 2002.

14. Morita, M., Kudo, H., Doi, Y., Hirano, T., Ikemura, K. & Fujimoto, S.: Enhanced immunocytochemical expression of antioxidant enzymes in rat submandibular gland after normobaric oxygenation. Anat. Rec., 268 (4): 371-380, 2002.

15. Uchida, S., Sakai, A., Kudo, H., Otomo, H., Watanuki, M., Tanaka, M., Nagashima, M. & Nakamura, T.: Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats. Bone, 32 (5): 491-501, 2003.

16. 土肥良秋、工藤秀明、西野朋子、藤本 淳:血管発生と血管新生−新生血管形成に関する研究の沿革−,産業医科大学雑誌,25 (4): 409-417, 2003.

17. Hirano, T., Kudo, H., Doi, Y., Nishino, T., Fujimoto, S., Tsurudome, Y., Ootsuyama, Y. & Kasai, H.: Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liver. Cancer Science , 95 (2): 118-122, 2004.

18. Doi, Y., Kudo, H., Nishino, T., Kiyonaga, H., Nagata, T., Hamasaki, K. & Fujimoto, S.: The enhancement of endothelin-1 synthesis and processing in the acute hypoxic rat aorta. Proceedings of the 8th Asia-Pacific Conference on Electron Microscopy (8APEM), Tanaka, N., Takano, Y., Mori, H., Seguchi, H., Iseki, S., Shimada, H. & Simamura, E. (eds.), pp. 933-934, 2004.

19. Nagata, T., Kudo, H., Nishino, T., Doi, Y., Itoh, H. & Fujimoto, S.: Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Med. Mol. Morphol., 38 (3): 161-172, 2005.

20. 土肥良秋、立花利公、山口正視:電子顕微鏡技術認定試験の沿革,顕微鏡,40 (Suppl. 1): PB-7, 2005.

21. Fujimura, T., Suzuki, H., Shimizu, T., Tokui, N., Kitamura, T., Udaka, T. & Doi, Y.: Pathological alterations of strial capillaries in dominant white spotting W/Wv mice. Hear. Res., 209 (1-2), 53-59, 2005.

22. Shiraishi, M., Doi, Y., Kayashima, K. & Fujimoto, S.: Antioxidant enzyme immunoreactivity in rat von Ebner gland after nickel treatment. Med. Mol. Morphol., 41 (1): 44-52, 2008

23. Fujimura, T., Suzuki, H., Udaka, T., Shiomori, T., Mori, T., Inaba, T., Hiraki, N., Kayashima, K. & Doi, Y.: Immunoreactivities for glutathione S-transferases and glutathione peroxidase in the lateral wall of pigmented and albino guinea pig cochlea. Med. Mol. Morphol., 41 (3): 139-144, 2008.

24. Matsuoka, H., Harada, K., Endo, Y., Warashina, A., Doi, Y., Nakamura, J. & Inoue, M.: Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells. J. Physiol., 586 (Pt 20): 4825-4842, 2008

25. Kudo, H., Doi, Y., Ueda, H. & Kaeriyama, M.: Molecular characterization and histochemical demonstration of salmon olfactory marker protein in the olfactory epithelium of lacustrine sockeye salmon (Oncorhynchus nerka). Comp. Biochem. Physiol. A Mol. Inteqr. Physiol., 154 (1): 142-150, 2009.

26. Kudo, H., Doi, Y., & Fujimoto, S.: Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium: A possible role in the phase L xenobiotic metabolizing function. Neurosci. Lett., 468 (2): 98-101, 2010.

27. Miyamoto, T., Tamura, M., Kabashima, N., Serino, R., Shibata, T., Furuno, Y., Miyazaki, M., Baba, R., Sato, N., Doi, Y., Okazaki, M. & Otsuji, Y.: An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. Nephrol. Dial. Transplant., 25 (4): 1109-1119, 2010.

28. Sato, N., Morimoto, H., Baba, R., Nakamata, J., Doi, Y. & Yamaguchi, K.: Functional expression of double-stranded RNA-dependent protein kinase in rat intestinal epithelial cells. J. Cell Biochem., 110 (1): 104-111, 2010.

29. Asahi, J., Kamo, H., Baba, R., Doi, Y., Yamashita, A., Murakami, D., Hanada, A. & Hirano, T.: Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes. Life Sci., 87 (13-14): 431-438, 2010.

30. 山下修二,勝又 修,土肥良秋:4節免疫電顕法.In:電顕入門ガイドブック改訂版,(社)日本顕微鏡学会技術認定委員会(編),国際文献印刷社,東京,pp.77-90.

31. Kashiwagi, E., Izumi, H., Yasuniwa, Y., Baba, R., Doi, Y., Kidani, A., Arao, T., Nishio, K., Naito, S. & Kohno, K.: Enhanced expression of nuclear factor I/B in oxaliplatin-resistant human cancer cell lines. Cancer Sci., 102 (2): 382-386, 2011.


教育内容

     1.組織学(顕微解剖学)

     2.脈管学

     3.感覚器学

     4.内臓学

     5.人体発生学

更新日:2012年2月3日

文責:第2解剖学講座