教 授
土肥 良秋〔博士（医学）〕
キーワード
血管内皮細胞，ワイベル・パラーデ小体，免疫組織化学，重金属細胞毒性，電子顕微鏡
研究業績
1. Doi, Y. & Fujimoto, S.: Vasocontractions of the in-vitro toad aortas induced by endothelin-1 and sarafotoxin-S6b. Anat. Rec., 235 (2): 253-260, 1993.
2. Hara, K., Yoshizuka, M., Doi, Y. & Fujimoto, S.: Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase. Occup. Environ. Med., 51 (3): 735-738, 1994.
3. Doi, Y., Ozaka, T., Katsuki, M., Fukushige, H., Toyama, E., Kanazawa,Y., Arashidani, K. & Fujimoto, S.: Histamine release from Weibel-Palade bodies of toad aortas induced by endothelin-1 and sarafotoxin-S6b. Anat. Rec., 242 (3): 374-382, 1995.
4. Doi, Y., Ozaka, T., Fukushige, H., Furukawa, H., Yoshizuka, M. & Fujimoto, S.: Increase in number of Weibel-Palade bodies and endothelin-1 release from endothelial cells in the cadmium-treated rat thoracic aorta. Virchows Archiv., 428 (6): 367-373, 1996.
5. Kudo, H., Doi, Y., Nishino, T., Nara, S., Hamasaki, K. & Fujimoto, S.: Dietary zinc deficiency decreases glutathione S-transferase expression in the rat olfactory epithelium. J. Nutr., 130 (1): 38-44, 2000.
6. Doi, Y., Peng, H., Kudo, H., Hamasaki, K. & Fujimoto, S.: Expressionof α-calcitonin gene-related peptide in the enteric nervous system of ratsmall intestine. Neurosci. Lett., 285 (1): 33-36, 2000.
7. Uchida, S., Doi, Y., Kudo, H., Furukawa, H., Nakamura, T. & Fujimoto, S.: Transient expression of activin β A mRNA on osteoprogenitor cells in rat bone regeneration after drill-hole injury. Bone, 27 (1): 81-90, 2000.
8. Fukushige, H., Doi, Y., Kudo, H., Kayashima, K., Kiyonaga, H., Nagata,T., Itoh, H. & Fujimoto, S.: Synthesis and receptor sites of endothelin-1in the rat liver vasculature. Anat. Rec., 259 (4): 437-445, 2000.
9. Doi, Y., Kudo, H., Nishino, T., Kayashima, K., Kiyonaga, H., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells. Histol. Histopathol., 16 (4): 1073-1079, 2001.
10. Doi, Y., Kudo, H., Nishino, T., Yamamoto, O., Nagata, T., Nara, S., Morita, M. & Fujimoto, S.: Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Histol. Histopathol., 17 (1): 97-105, 2002.
11. Doi, Y., Kudo, H., Yamamoto, O., Hamasaki, K., Yoshizuka, M. & Fujimoto, S.: Enhancement of immunoreactivity for endothelin-1 and endothelin converting enzyme-1 in the cadmium-treated rat thoracic aorta. Virchows Arch., 441 (2): 179-186, 2002.
12. Doi, Y., Kudo, H., Nishino, T., Kiyonaga, H., Nagata, T., Hamasaki, K. & Fujimoto, S.: The enhancement of endothelin-1 synthesis and processing in the acute hypoxic rat aorta. Proceedings of the 8th Asia-Pacific Conference on Electron Microscopy (8APEM), Tanaka, N., Takano, Y., Mori, H., Seguchi, H., Iseki, S., Shimada, H. & Simamura, E. (eds.), pp. 933-934, 2004.
13. Hirano, T., Kudo, H., Doi, Y., Nishino, T., Fujimoto, S., Tsurudome, Y., Ootsuyama, Y. & Kasai, H.: Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3’-methyl-4-dimethylamino-azobenzene-treated mouse liver. Cancer Science (Cancer Sci.), 95 (2): 118-122,2004.
14. Yanagi, S., Kudo, H., Doi, Y., Yamauchi, K. & Ueda, H.: Immunohistochemical demonstration of salmon olfactory glutathione S-transferase class pi (N24) in the olfactory system of lacustrine sockeye salmon during ontogenesis and cell proliferation.Anat. Embryol., 208 (3): 231-238,2004.
15. Nagata, T., Kudo, H., Nishino, T., Doi, Y., Itoh, H. & Fujimoto, S.: Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Med. Mol. Morphol., 38 (3): 161-172, 2005.
16. Fujimura, T., Suzuki, H., Shimizu, T., Tokui, N., Kitamura, T., Udaka, T. & Doi, Y.: Pathological alterations of strial capillaries in dominant white spotting W/Wv mice. Hear. Res., 209 (1-2): 53-59, 2005.
17. 土肥良秋：怒ると怖い血管内皮細胞．ミクロｽコピア，24 (2): 98-104, 2007.
18. Shiraishi, M., Doi, Y., Kayashima, K. & Fujimoto, S.: Antioxidant enzyme immunoreactivity in rat von Ebner gland after nickel treatment. Med. Mol. Morphol., 41 (1): 44-52, 2008.
19. Fujimura, T., Suzuki, H., Udaka, T., Shiomori, T., Mori, T., Inaba, T., Hiraki, N., Kayashima, K. & Doi, Y.: Immunoreactivities for glutathione S-transferases and glutathione peroxidase in the lateral wall of pigmented and albino guinea pig cochlea. Med. Mol. Morphol., 41 (3): 139-144, 2008.
20. Matsuoka, H., Harada, K., Endo, Y., Warashina, A., Doi, Y., Nakamura, J. & Inoue, M.: Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells. J. Physiol., 586 (Pt 20): 4825-4842, 2008.
21. Kudo, H., Doi, Y., Ueda, H. & Kaeriyama, M.: Molecular characterization and histochemical demonstration of salmon olfactory marker protein in the olfactory epithelium of lacustrine sockeye salmon (Oncorhynchus nerka). Comp. Biochem. Physiol. A Mol. Inteqr. Physiol., 154 (1): 142-150, 2009.
22. Kudo, H., Doi, Y., & Fujimoto, S.: Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium: A possible role in the phase Ⅲ xenobiotic metabolizing function. Neurosci. Lett., 468 (2): 98-101, 2010.
23. Miyamoto, T., Tamura, M., Kabashima, N., Serino, R., Shibata, T., Furuno, Y., Miyazaki, M., Baba, R., Sato, N., Doi, Y., Okazaki, M. & Otsuji, Y.: An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. Nephrol. Dial. Transplant., 25 (4): 1109-1119, 2010.
学会活動
日本解剖学会，日本顕微鏡学会，日本臨床分子形態学会
更新日：２０１２年２月２日
文責：第２解剖学講座