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大学院生募集中
 Aldh2 KO mouse
Research
Society of Aldh2 KO mouse
Front page in
English
Front page in
Japanese
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Publications
2007
Matsuda T, Matsumoto A, Uchida M, Kanaly R, Misaki K, Shibutani S, Kawamoto
T, Kitagawa K, Nakayama KI, Tomokuni K, Ichiba M. ( in press) Increased formation of hepatic
N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde
dehydrogenase 2 knockout mice treated with ethanol.
Carcinogenesis. 2007 Mar 14; [Epub
ahead of print]
Narai R, Oyama T, Ogawa M, Yamaguchi T, Kinaga
T, Murakami T, Isse T, Ozaki S, Yashima
Y, Okabayashi K, Ochiai
H, Yarita K, Fujino A,
Kawamoto T. (2007) HBV- and HCV- infected workers in the Japanese workplace. J Occup
Health. 49(1), 9-16.
Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, Steinhoff L, Brandt M, Kleschyov
AL, Schulz E, Lange K, Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Munzel
T, Daiber A. (2007) Number of nitrate groups
determines reactivity and potency of organic nitrates: a proof of concept
study in ALDH-2-/- mice. Br J Pharmacol. 150(4),526-33.
Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y,
Endo Y, Kawamoto T. (2007) A comparison of covalent binding of ethanol
metabolites to DNA according to Aldh2 genotype. Toxicol
Lett. 168(2), 148-54.
Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T. (2007) Susceptibility
to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. Front Biosci. 2007, 12:1927-34. http://www.bioscience.org/inpress/2198.pdf
Oyama T, Sugio K, Uramoto H, Kawamoto T,
Kagawa N, Nadaf S, Carbone
D, Yasumoto K. (2007) Cytochrome
P450 expression (CYP) in non-small cell lung cancer. Front Biosci. 12, 2299-308.
2006
Ogawa M, Oyama T, Isse
T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T. (2006) Hemoglobin adducts as
a marker of exposure to chemical substances, especially PRTR class I
designated chemical substances. J Occup Health. 48(5),
314-28.
S. Ozaki, T. Oyama, T. Isse, N. Kagawa, H. Uramoto,K.
Sugio, K. Yasumoto, K. Kono, T. Kawamoto (2006) Smoking cessation program and
CYP2A6 polymorphism. Front Biosci. 11, 2590-2597.
Ogawa, T. Isse, T. Oyama, N. Kunugita, T. Yamaguchi, T.
Kinaga, R. Narai, A. Matsumoto, Y.D. Kim, H. Kim, I. Uchiyama, and T.
Kawamoto. (2006) Urinary 8-hydroxydeoxyguanosine (8-OHdG) and plasma
malondialdehyde (MDA) levels in Aldh2 knock-out mice under acetaldehyde
exposure. Industrial Health 44, 179-183
B. Kis, T. Iss, J.A. Snipe, L. Chen, H. Yamashit, Y. Ueta, and D.W. Busij.
(2006) Effects of LPS stimulation on the expression of prostaglandin carriers
in the cell of the blood-brain and blood-cerebrospinal fluid barriers. J App
Physiol 100, 1392-1399.
2005
T. Isse, T. Oyama, K. Matsuno, M.Ogawa, R. Narai-Suzuki, T. Yamaguchi, T.
Murakami, T. Kinaga, I. Uchiyama, and T. Kawamoto. (2005) Paired acute
inhalation test revealed that acetaldehyde toxicity was higher in aldehyde
dehydrogenase 2 knockout mice than in wild-type mice. J Toxicol Sci 30,
329-337
T. Isse, T. Oyama, K. Matsuno, I.
Uchiyama, and T. Kawamoto. (2005) Aldehyde dehydrogenase 2 activity affects
the symptoms produced by an intraperitoneal acetaldehyde injection, but not
acetaldehyde lethality. J Toxicol Sci 30, 315-328
T. Isse, T. Oyama, K. Matsuno, K. Kitagawa, M. Ogawa, T. Kinaga,
R. Suzuki-Narai, T. Yamaguchi, I.
Uchiyama, and T. Kawamoto. (2005)Acetaldehyde Elimination Changes in
Transgenic Mice Lacking Aldehyde Dehydrogenase 2 Activity. In Enzymology and
Molecular Biology of Carbonyl Metabolism 12, edited by: Henry Weiner, Purdue
University Press, Ashland OH USA, pp
33-44.
T. Isse, K. Matsuno, T. Oyama , K. Kitagawa and T. Kawamoto.
(2005) Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity
shows high acetaldehyde level in blood, brain and liver after ethanol
gavages. Alcoholism: Clinical and Experimental Research.,29, 1959-1964
Z. Chen, M.W. Foster, J. Zhang, L. Mao, H. A. Rockman, T.
Kawamoto, K. Kitagawa, K. Nakayama, D.T. Hess, and J.S. Stamler. (2005) An
essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin
bioactivation. PNAS, 102, 12159–12164.
T. Oyama, M. Morita, T. Isse, N. Kagawa, S. Nakata, T. So, M.
Mizukami, K. Ono, M. Sugaya, H. Uramoto, T. Yoshimatsu, T. Hanagiri, K.
Sugio, T. Kawamoto and K. Yasumoto. (2005) Immunohistochemical evaluation of
cytochrome P450 (CYP) and p53 in breast cancer. Front Biosci.,10, 1156-1161
M. Morita, H. Uramoto, S. Nakata, K. Ono, M. Sugaya, T.
Yoshimatsu, T. Oyama, T. Hanagiri, K. Sugio, and K. Yasumoto. (2005)
Expression of deltaNp63 in squamous cell carcinoma of the esophagus.
Anticancer Res, 25, 3533-3539.
M. Morita, T. Oyama, N. Kagawa, S. Nakata, K. Ono, M. Sugaya, H.
Uramoto, T. Yoshimatsu, T. Hanagiri K. Sugio, Y. Kakeji, and K. Yasumoto.
(2005) Expression of aldehyde dehydrogenase 2 in the normal esophageal
epithelium and alcohol consumption in patients with esophageal cancer. Front
Biosci., 10, 2319-2324.
T. Yoshimatsu, H. Uramoto, T. Oyama, Y. Yashima, C. Gu, M.
Morita, K. Sugio, K. Kohno, and K.Yasumoto. (2005) Y-box-binding protein-1
expression is not correlated with p53 expression but with proliferating cell
nuclear antigen expression in non-small cell lung cancer. Anticancer Res.,
25, 3437-3443.
Y.D. Kim, T. Oyama, T. Isse, K. Kitagawa, M. Ogawa, T.
Yamaguchi, R. Suzuki, T. Kinaga, Y. H. Kim and T. Kawamoto (2005) Expression levels
of hepatic cytochrome p450 enzymes in Aldh2 deficient mice following ethanol
exposure; a pilot study. Archives of Toxicology,79, 192-195
T. Oyama, T. Osaki, T. Baba, Y. Nagata, M. Mizukami, T. So, S.
Nakata, Y. Ichiki, H. Uramoto, M. Sugaya, T. Yoshimatsu, M. Morita, T.
Hanagiri, K. Sugio, T. Kawamoto, and K. Yasumoto. (2005) Molecular genetic
tumor markers in non-small cell lung cancer. Anticancer Res., 25, 1193-1196.
T. Oyama, T. Isse, N. Kagawa, T. Kinaga, Y. D. Kim, M. Morita,
K. Sugio, H. Weiner, K. Yasumoto, and T. Kawamoto. (2005) Tissue-distribution
of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the
expression of enzyme involved in alcohol metabolism. Front Biosci.,10,
951-960
Y.D. Kim, Y.J. Ko, T. Kawamoto and H. Kim (2005) The effects of
1-nitropyrene on oxidative DNA damage and expression of DNA repair enzymes. J
Occup Health. 47, 261-6.
2004
Y. D. Kim, H. Todoroki, T. Oyama, T. Isse, A. Matsumoto, T. Yamaguchi, H.
Kim, I. Uchiyama and T. Kawamoto (2004) Identification of cytochrome P450
isoforms involved in 1-hydroxylation of pyrene. Environ.Res, 94, 262-266.
T. Oyama, N. Kagawa, N. Kunugita, K. Kitagawa, M. Ogawa, T.
Yamaguchi, R. Suzuki, T. Kinaga, Y. Yashima, S. Ozaki, T. Isse, Y. D. Kim, H.
Kim and T. Kawamoto (2004) Expression of cytochrome P450 in tumor tissues and
its association with cancer development. Front Biosci., 9, 1967-1976.
C. Gu, T. Oyama, T. Osaki, J. Li, M. Takenoyama, H. Izumi, K.
Sugio, K. Kohno, and K. Yasumoto. (2004)
Low expression of polypeptide GalNAc N-acetylgalactosaminyl
transferase-3 in lung adenocarcinoma: impact on poor prognosis and early
recurrence. Br J Cancer. 90, 436-42.
H. Uramoto, K. Sugio, T. Oyama, S.Nakata, K. Ono, M. Morita, K.
Funa, and K. Yasumoto.(2004) Expression of deltaNp73 predicts poor prognosis
in lung cancer. Clin Cancer Res. 10, 6905-11.
2003
Y.D. Kim, S.C. An, T.
Oyama, T. Kawamoto, H. Kim. (2003) Oxidative stress, hogg1 expression and
NF-kappaB activity in cells exposed to low level chromium. J Occup Health.,
45, 271-277.M. Yang, M. Yoshikawa, K. Arashidani, and T. Kawamoto. (2003)
Effects of green tea on carcinogen-induced hepatic CYP1As in C57BL/6 mice.
Eur.J.Cancer Prev. 12, 391-395
M. Yang, J.Y. Jang, S. Kim, S.M. Lee, S.S. Chang, H.K. Cheong,
E. Lee, D. Kang, H. Kim, T.
Kawamoto, and H.D. Shin. (2003) Genetic effects on urinary 1-hydroxypyrene
levels in a Korean population. Carcinogenesis, 24, 1085-1089.
M. Yang, S.Y. Kim, S.M. Lee, S.S. Chang, T. Kawamoto, J. Y.
Jang, and Y.O. Ahn. (2003) Biological monitoring of bisphenol a in a Korean
population. Arch.Environ.Contam Toxicol., 44, 546-551.
M. Munaka, K. Kohshi, T. Kawamoto, S. Takasawa, N.
Nagata, H. Itoh,
S. Oda, and T. Katoh.(2003) Genetic polymorphisms of tobacco- and
alcohol-related metabolizing enzymes and the risk of hepatocellular
carcinoma. J.Cancer Res Clin Oncol., 129, 355-360
B. Kis, J. A. Snipes, T. Isse, K. Nagy and D. W. Busija (2003)
Putative cyclooxygenase-3 expression in rat brain cells. J.Cereb.Blood Flow
Metab, 23, 1287-1292.
T. Oyama, A. Matsumoto, T. Isse, Y. D. Kim, S. Ozaki, T. Osaki,
K. Sugio, K. Yasumoto and T. Kawamoto (2003) Evidence-based prevention (EBP):
approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1
polymorphism. Anticancer Res, 23, 1731-1737.
T. Oyama, T. Osaki, T. Isse, Y. Yashima, S. Ozaki, S. Nakata, H.
Uramoto, M. Sugaya, M. Yasuda, T. Yamashita, M. Inoue, M. Takenoyam, T.
Hanagiri, K. Sugio, T. Hamada, T. Kawamoto and K. Yasumoto (2003) Pleomorphic
carcinoma: report of a case with massive pleural effusion and asbestos
particles. Ann.Thorac.Cardiovasc.Surg., 9, 126-129.
T. Oyama, T. Kawamoto, K. Matsuno, T. Osaki, A. Matsumoto, T.
Isse, S. Nakata, S. Ozaki, M. Sugaya, M. Yasuda, T. Yamashita, M. Takenoyama,
K. Sugio and K. Yasumoto (2003) A case-case study comparing the usefulness of
serum trace elements (Cu, Zn and Se) and tumor markers (CEA, SCC and SLX) in
non-small cell lung cancer patients. Anticancer Res, 23, 605-612.
A. Matsumoto, N. Kunugita, K.
Kitagawa, T. Isse, T. Oyama, G. L. Foureman, M. Morita and T. Kawamoto (2003)
Bisphenol A levels in human urine. Environ.Health Perspect., 111, 101-104.
2002
Y. Kodama, K. Arashidani, N. Tokui, T. Kawamoto, K. Matsuno, N. Kunugita, and
N. Minakawa. (2002) Environmental NO2 concentration and exposure in daily
life along main roads in Tokyo.
Environ.Res, 89, 236-244
T. Oyama, T. Kawamoto, A. Matsumoto, T. Isse, S. Ozaki and K.
Yasumoto (2002) [Evidence based prevention (EBP): evidence-based approach to
prevention of lung cancer by application of cytochrome 2E1 polymorphism].
J.UOEH., 24, 413-421.
T. Isse, T. Oyama, K. Kitagawa, K. Matsuno, A. Matsumoto, A.
Yoshida, K. Nakayama, K. Nakayama and T. Kawamoto (2002) Diminished alcohol
preference in transgenic mice lacking aldehyde dehydrogenase activity.
Pharmacogenetics, 12, 621-626.
R.S. Wang, T. Nakajima, T. Kawamoto, and T. Honma (2002) Effects
of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of
structurally different aldehydes in human liver. Drug Metab
Dispos. 30, 69-73.
B. Kis, H. Kaiya, R. Nishi, M. A. Deli, C. S. Abraham, T.
Yanagita, T. Isse, S. Gotoh, H. Kobayashi, A. Wada, M. Niwa, K. Kangawa, J.
Greenwood, H. Yamashita and Y. Ueta (2002) Cerebral endothelial cells are a
major source of adrenomedullin. J.Neuroendocrinol., 14, 283-293.
T. Osaki, T. Oyama, C.D. Gu, T. Yamashita, T. So, M. Takenoyama,
K. Sugio, and K. Yasumoto K. (2002) Prognostic impact of micrometastatic
tumor cells in the lymph nodes and bone marrow of patients with completely
resected stage I non-small-cell lung cancer. J Clin Oncol. 2002 20, 2930-6.
C.D. Gu, T. Osaki, T. Oyama, M. Inoue, M. Kodate, K. Dobashi, T.
Oka, and K. Yasumoto K. (2002) Detection of micrometastatic tumor cells in
pN0 lymph nodes of patients with completely resected nonsmall cell lung
cancer: impact on recurrence and Survival. Ann Surg. 235, 133-9.
T. Kasai, T. Nishizawa, H. Arioto, K. Nagano, S. Yamamoto, T.
Matsushima, and T. Kawamoto, T. Acute
and Subcronic inhalation toxicity of chloroform in rats and mice. Jounal of Occupational Health 2002
44(4):
H. Tsukino, Y. Kuroda, H. Nakao, H. Imai, Y. Osaka, H. Inatomi,
K. Kitagawa, T. Kawamoto, and T. Katoh.
Genetic polymorphisms of CYP2A6 and CYP2E1 with tobacco smoking is not
associated with risk of urothelial cancer. Environmental Health and Preventive
Medicine 2002 7(3):
D. Gabrilovich, P. Cheng, Y. Fan, B. Yu, E. Nikitina, A.
Sirotkin, M. Shurin, T. Oyama, Y. Adachi, S. Nadaf, D. Carbone, and A.
Skoultchi. Detection of micrometastatic tumor cells in pNO lymph nodes of
patients with completely resected nonsmall cell lung cancer; Impact on
recurrence and survival J
Leukoc Biol 2002;72:
2001
M. Yang, N. Kunugita,K. Kitagawa,S.H. Kang, B. Coles, F.F. Kadlubar, T.
Katoh, K. Matsuno, and T. Kawamoto. (2001) Individual differences in urinary
cotinine levels in Japanese smokers: relation to genetic polymorphism of
drug-metabolizing enzymes. Cancer Epidemiol.Biomarkers Prev. 10, 589-593.
N. Kunugita, K. Kohshi, Y. Kinoshita, T. Katoh, H. Abe, T. Tosaki,
T. Kawamoto, and T. Norimura. (2001) Radiotherapy after hyperbaric
oxygenation improves radioresponse in experimental tumor models. Cancer
Lett., 164, 149-154.
M. Yang, N. Kunugita,K. Kitagawa,S.H. Kang, B. Coles, F.F.
Kadlubar, T. Katoh, K. Matsuno, and T. Kawamoto. (2001) Individual
differences in urinary cotinine levels in Japanese smokers: relation to
genetic polymorphism of drug-metabolizing enzymes. Cancer
Epidemiol.Biomarkers Prev. 10,
589-593.
N. Kunugita, K. Kohshi, Y. Kinoshita, T. Katoh, H. Abe, T.
Tosaki, T. Kawamoto, and T. Norimura. (2001) Radiotherapy after hyperbaric
oxygenation improves radioresponse in experimental tumor models. Cancer
Lett., 164, 149-154.
B. Kis, M. A. Deli, H. Kobayashi, C. S. Abraham, T. Yanagita, H.
Kaiya, T. Isse, R. Nishi, S. Gotoh, K. Kangawa, A. Wada, J. Greenwood, M.
Niwa, H. Yamashita and Y. Ueta (2001) Adrenomedullin regulates blood-brain
barrier functions in vitro. Neuroreport, 12, 4139-4142.
H. Kim, S. Cho, J.Kang, Y. Kim, H. Nan, C. Lee, H. Lee and T.
Kawamoto. (2001) Urinary 1-hydropyrene and 2-naphtol concentrations in male
Koreans. Int Arch. Occup Environ Health 74, 59-62.
H. Nan, H. Kim, H. Lim, J. Choi, T. Kawamoto, J. Kang, S. Cho,
J. Kang, C. Lee, Y. Kim and. E. Kwon. (2001) Effect of occupation, lifestyle
and genetic polymorphism of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary
1-hydroxypyrene and 2-naphtol concentration. Carcinogenesis 22, 787-793.
H. Uramoto, R. Nakanishi, Y. Fujino, H. Imoto, M. Takenoyama, T.
Yoshimatsu, T. Oyama and K. Yashumoto. (2001) Prediction of pulmonary
complications after a lobectomy in patients with non-small cell lung cancer.
Thorax 56, 59-61.
M.M. Dikov, T. Oyama, P. Cheng, P. Cheng, T. Takahashi, K.
Takahashi, T. Sepetavec, B. Edwards, Y. Adachi, S. Nadaf, T. Daniel, D.I.
Gabrilovich and D.P. Carbone. (2001) Vascular endothelial growth factor
effects on nuclear factor-kappa-B activation in hematopoietic progenitor
cell. Cancer Res. 61, 2051-2021.
K. Kitagawa, N. Kunugita, M. Kitagawa and T. Kawamoto. (2001) CYP2A6*6,
a novel polymorphism in cytochrome P450 2A6, has a single amino acid
substitution (R128Q) that inactivates enzymatic activity. J Biol Chem 276,
17830-17835
2000
Katoh, T., Boissy, R., Nagata, N., Kitagawa, K., Kuroda, Y., Itoh, H.,
Kawamoto, T., Bell, D.A. (2000) Inherited polymorphism in the
N-actyltransferase 1 (NAT1) and 2 (NAT2) genes and susceptibility to gastric
and colorectal adenocarcinoma. International Journal of Cancer 85, 46-49.
Yang, M., Katoh, T., Delongchamp, R., Ozawa, S., Kohshi, K.,
Kawamoto ,T. (2000) Relationship between NAT1 genotype and phenotype in a
Japanese population. Pharmacogenetics 10, 225-232
Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T.,
Okamoto, K., Yoshida, A., Nakayama, K., Nakayama, K. (2000) Aldehyde dehydrogenase
(ALDH)2 associates with oxidation of methoxyacetaldehyde; in vitro analysis
with liver subcellular fraction derived from human and Aldh2 gene targeting
mouse. FEBS Letters 476, 306-311
Obata, T., Tomaru, K., Nagakura, T., Izumi, Y., Kawamoto, T.
(2000) Smoking and oxidant stress: assay of isoprostane in human urine by gas
chromatography-mass spectrometry. Journal of Chromatography B 746 (1), 11-15
1999
Yang, M., Koga, M., Katoh, T., Kawamoto, T. (1999) A study for the proper
application of urinary naphthols, new biomarkers for airborne polycyclic
aromatic hydrocarbons. Archives of Environmental Contamination and
toxicology. 36, 99-108.
Katoh, T., Nakano, M., Yoshioka, M., Inatomi, H., Matsumoto, T.,
Kawamoto, T.(1999) Urothelial cancer risk in relation to genotypes of
glutathione s-transferase (GST) M1, T1, P1 and N-acetyltransferase 2 (NAT2),
and tobacco smoking. Journal of Occupational Health. 41, 12-18.
Arashidani, K., Yoshikawa, M., Kawamoto, T., Matsuno, K.,
Kodama, Y. (1999) A study of air pollution in the smoking hall. Japanese
Journal of Hygiene. 53, 626-631. (Japanese)
Katoh, T., Kaneko,S., Takasawa,S., Nagata,N., Inatomi,H.,
Ikemura,K., Itoh,H., Matumoto,T., Kawamoto,T., Douglas,
A.Bell. (1999) Human glutathione S-transferase P1 polymorphism and
susceptibility to smoking related epithelial cancer; oral, lung, gastric,
colorectal and urothelial cancer. Pharmacogenetics . 9, 165-169.
Katoh, T., Inatomi, H., Yang, M., Kawamoto, T., Matumoto,T., Douglas,
A.Bell. (1999). Arylamine N-acetyltransferase 1(NAT1) and 2(NAT2) genes and
risk of urothelial transitional cell carcinoma among Japanese.
Pharmacogenetics 9, 401-404.
Kitagawa, K., Kunugita, N., Katoh, T., Yang, M., Kawamoto, T.
(1999) The Significance of the Homozygous CYP2A6 Deletion on Nicotine
Metabolism:A New Genotyping Method of CYP2A6 Using a Single PCR-RFLP.
Biochemical and Biophysical Research Communications 262, 146-151.
Inatomi,H., Katoh, T., Kawamoto,T., Matumoto,T. (1999) NAT2 gene
polymorphism as a possible marker for susceptibility to bladder cancer in
Japanese. International Jourmal of Urology 6, 446-454.
Kim, H., Kim, Y-D., Lee, H., Kawamoto, T., Yang, M., Katoh, T.
(1999) Assay of 2-naphthol in human urine by high performance liquid
chromatography. Journal of Chromatography B 734, 211-217.
Katoh, T., Kaneko, S., Kohshi, K., Munaka, M., Kitagawa, K.,
Kunugita, N., Ikemura, K., Kawamoto, T. (1999) Genetic polymorpshims of
tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.
International Journal of Cancer 83, 606-609
1998
Arashidani, K., Kawamoto, T., Kodama, Y. (1998) Induction of sister-chromatid
exchange by ethylene glycol monomethyleter and its metabolite. Industrial
Health. 36, 27-31.
Yang, M., Kawamoto, T., Katoh, T., Mastuno, K. (1998) Effects of
lifestyle and genetic polymorphisms on consumption of coffee or black tea and
urinary caffeine levels. Biomarkers. 3, 367-377.
Katoh, T., Inatomi, H., Kim, H., Yang, M., Matsumoto, T.,
Kawamoto, T. (1998) Effects of glutathione S-transferase (GST) M1 and GSTT1
genotypes on urothelial cancer risk. Cancer Letters. 132, 147-152.
1997
Oyama, T., Kawamoto, T., Mizoue, T., Yasumoto, K., Kodama, Y., Mitsudomi, T. (1997)
N-Acetylation polymorphism in patients with lung cancer and its association
with p53 gene mutation.
Anticancer Research. 17, 577-582.
Oyama, T., Kawamoto, T., Mizoue, T., Sugio, K., Kodama, Y.,
Mitsudomi, T., Yasumoto, K. (1997) Cytochrome P450 2E1 polymorphism as a risk
factor for lung cancer: In relation to p53 gene mutation. Anticancer Research.
17, 583-588.
Yang, M., Yamamura, K., Yan, Y., Fukamachi, Y., Hirano, T.,
Kawamoto, T., Higashi, K. (1997) Studies on the microsomal cytochrome P450s
in the livers of carcinogen-resistant and sensitive rats during long-term
administration of 3'-methyl-4-dimethylaminoazobenzene. Journal of UOEH. 19,
277-286.
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki T.,
Sugio, K., Yasumoto, K., Mitsudomi, T. (1997) p53 mutations of lung cancer
are not significantly affected by CYP1A1 or GSTM1 polymorphisms.
International Journal of Oncology. 11, 305-309.
1996
Kawamoto, T., Koga, M., Oyama, T., Kodama, Y. (1996) Habitual and genetic
factors that affect urinary background levels of biomarkers for organic
solvent exposure. Archives of Environmental Contamination and Toxicology .
30, 114-120.
Arashidani, K., Yoshikawa, M., Kawamoto, T., Matsuno, K., Kayama, F., Kodama,
Y. (1996). Indoor pollution from heating. Industrial Health. 34, 205-215.
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