1. –@‘º@r”V (ˆãŠw”ŽŽm)

2. ’áü—Ê•úŽËü, p53ˆâ“`Žq, ƒAƒ|ƒg[ƒVƒX, “Ë‘R•ÏˆÙ, “dŽ¥ê

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Okazaki, R., Ootsuyama, A., Kakihara, H., Mabuchi, Y., Matsuzaki, Y., Michikawa, Y., Imai, T., Norimura, T.F Dynamics of delayed p53 mutations in mice given whole-body irradiation at 8 weeks , Int. J. Radiation Oncology Biol. Phys, 79(1):247-254(2011)

‘å’ÃŽR@²A‰ªú±@—´ŽjA–@‘º@r”VF‚‚T‚Rˆâ“`Žqƒnƒvƒ•s‘S‚Ì”­‚ª‚ñ‰ß’ö‚Ö‚ÌŠÖ—^A•úŽËü¶•¨Œ¤‹†@45i4j:396-407 (2010)

Okazaki, R. , Mabuchi, Y. , Yoshida, Y. , Suzuki, S. , ‚cing, ‚m. , Matsuzaki, Y. , Ootsuyama, A. , Norimura, T. : The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice, Int. J. Radiat. Biol., 86(11):927-934(2010)

Okudaira, N. , Uehara, Y. , Fujikawa, K. , Kagawa, N. , Ootsuyama, A. , Norimura, T. , Saeki, K. , Nohmi, T. , Matumura, K. , Matsumoto, T. , Oghiso, Y. , Tanaka, K. , Ichinohe, K. , Nakamura, S. , Tanaka, S. , Ono, T. : Radiation Dose-Rate Effect on Mutation Induction in Spleen and Liver of gpt delta Mice, Radiation Research, 173(2):138-147(2010)

Umata, T., Kunugita, N. & Norimura, T.: A comparison of the mutagenic and apoptotic effects of tritiated water and acute of chronic caesimu-137 gamma exposure on spleen T lymphocytes on normal and p53-deficient mice, Int. J. Radiat. Biol.,85(12):1082-1088(2009)

‰ªú±@—´ŽjA‘å’ÃŽR@²A–@‘º@r”VF˜V‰»‚̃gƒsƒbƒNƒX[ƒeƒƒƒAAƒ~ƒgƒRƒ“ƒhƒŠƒAA‚53A•úŽËü¶•¨Œ¤‹†@44i2j:127-139i2009j

Igari, Y., Igari, K., Kunugita, N., Ootsuyama, A., Norimura, T.: Prolonged Increase in T-Cell Receptor(TCR) Variant Fractions of Spleen T Lymphocytes in Pregnant Mice after gamma Irradiation. Radiat. Res.,168(1):81-86(2007)

Okazaki , R., Ootsuyama, A., Norimura, T.: TP53 and TP53-Related Genes Associated with Protection from Apoptosis in the Radioadaptive Response. Radiat. Res. 167(1):51-57(2007)

Igari, K., Igari, Y.,Okazaki, R., Kato, F., Ootsuyama, A., Norimura, T.: The Delayed Manifestation of T-cell Receptor (TCR) Variants in X-irradiated Mice Depends on Trp 53 Status. Radiat. Res.,166(1):55-60(2006)

Okazaki , R., Moon, Y., Norimura, T., Eling, T.E.: Ionizing Radiation Enhances the Expression of NonSteroidal Anti-Inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells. Radiat. Res.,165(2):125-130(2006)

Okazaki, R., Ootsuyama, A., Norimura, T.: Radioadaptive Response for Protection against Radiation-Induced Teratogenesis. Radiat. Res., 163(3):266-270(2005)

Okazaki, R., Sakai, A. , Ootsuyama, A. , Sakata, T. , Nakamura, T. , Norimura, T.: Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice. Ann. Rheum. Dis., 63(4):453-456(2004)

Ootsuyama, A., Okazaki, R., Norimura, T.: Effect of exposure to low-dose rate radiation on autoimmune diseases of immunologically suppressed MRL/MpTn-gld/gld mice. J. Radiat. Res., (44):243-247(2003)

Okazaki, R.,Sakai, A.,Ootsuyama, A.,Sakata, T.,Nakamura, T.,Norimura, T.: Apoptosis and p53 expression in chondrocytes relate to degeneration in articular cartilage of immobilized knee joints. J. Rheum., 30(3):559-566(2003)

Kato, F.,Kakihara, H.,Kunugita, N.,Ootsuyama, A.,Norimura, T.: Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice. J. Radiat. Res., 43(Supl):209-212(2002)

Norimura, T., Kato, F. : Essential role of p53 gene in apoptotic tissue repair for radiation-induced teratogenic injury. Radiation and Homeostasis : 423-429(2002)

Okazaki , R., Ootsuyama, A., Uchida, S., Norimura, T. : Effects of a 4.7 T Static Magnetic Field on Fetal Development in ICR Mice. J. Radiat. Res., 42(3): 273-283(2001)

Kato, F., Ootsuyama, A., Nomoto, S., Kondo, S. and Norimura, T.: Threshold effect for teratogenic risk of radiation depends on dose-rate and p53-dependent apoptosis. Int. J. Radiat. Biol., 77(1) : 13-19(2001).

‰ªú±—´ŽjA–@‘ºr”VA’†‘º—˜F: ƒAƒ|ƒg[ƒVƒX‚ÆFas, p53A®Œ`EÐŠQŠO‰ÈA43(6):768-769(2000)

–@‘º@r”VFŠïŒ`‚Ì”­¶‚ð–h‚®p53F‘ÙŽ™‚ðŽç‚镪Žq‹@˜. p53[Šà—}§‚Ì•ªŽqƒƒJƒjƒYƒ€‚ƗՏ°‰ž—piŠÄC²’JGs,GŽÐj, 92-99(1998)

Nomoto, S., Ootsuyama, A., Shioyama, Y., Katsuki, M., Kondo, S. and Norimura, T.: The high susceptibility of heterozygous p53(+/-) mice to malformation after foetal@irradiation is related to sub-competent apoptosis. Int. J. Radiat. Biol., 74 : 419-429 (1998).

Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. & Kondo, S.: p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nature Medicine, 2(5) : 577-580(1996).

Mei, N., Imada, H., Nomoto, S., Kunugita, N. and Norimura, T. : Individual variation and age dependency in the radiosensitivity of peripheral blood T-lymphocytes from normal donors. J. Radiat. Res., 37 : 235-245 (1996).

Mei, N., Kunugita, N., Nomoto, S. and Norimura, T.: Comparison of the frequency of T-cell receptor mutants and thioguanine resistance induced by X-rays and ethylnitrosourea in cultured human blood T-lymphocytes. Mutation Research, 357 : 191-197 (1996).

Kunugita, N., Mei, N., Nomoto, S. and Norimura, T. : Measurement of the CD3-4+ variant T cell frequency by flow cytometry after X-irradiation on mice. J. Occupational Health, 38(1) : 25-29 (1996).

Imada, H. & Norimura, T. : Influence of PHA stimulation on the cytotoxicity and mutagenicity of X-rays and ethylnitrosourea in human peripheral blood T-lymphocytes. Mutation Research, 310(1) : 55-64(1994)

Norimura, T., Imada, H., Kunugita, N., Yoshida, N. & Nikaido, M. : Effects of strong magnetic fields on cell growth and radiation response of human T-lymphocytes in culture. J UOEH, 15(2) : 103-112(1993)

Norimura, T., Maher, V. M. & McCormick, J .J. : Cytotoxic and mutagenic effect of UV, ethylnitrosourea and (})-7ƒÀ, 8ƒ¿-dihydroxy-9ƒ¿, 10ƒ¿-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene in diploid human T -lymphocytes in culture: comparison with fibroblasts. Mutagenesis, 5(5) : 447-451(1990)

Norimura, T., Maher, V. M. & McCormick, J. J. : A quantitative assay for measuring the induction of mutations in human peripheral blood T-lymphocytes. Mutation Research, 230(1) : 101-109(1990)

Norimura, T., Tsuchiya, T., Hatakeyama, S., Yamamoto, H.& Okajima, S.: Long-term tissue distribution and steady state activity ratios of 232Th and its daughters in rats after intravascular injection of Thorotrast. J.UOEH, 11(3) : 287-297(1989)

Norimura, T. & Tsuchiya, T.: Long-Term effect of whole-body X-irradiation on cell-mediated immune reaction in mice. J. Radiation Research, 30 : 226-237 (1989)

4. Šw‰ïŠˆ“®

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