1. ‘å’ÃŽR�@�² (�bˆãŠw”ŽŽm)

2. •úŽË�ü�¶•¨Šw, ”­Šà, ƒAƒ|ƒg�[ƒVƒX, ŽÀŒ±“®•¨

3. Œ¤‹†‹Æ�Ñ

‚n‚�‚”‚“‚•‚™‚�‚�‚��@‚`�D�h‚c‚�‚“‚…�|‚d‚†‚†‚…‚ƒ‚”�@‚q‚…‚Œ‚�‚”‚‰‚�‚Ž‚“‚ˆ‚‰‚��@‚‚‚…‚”‚—‚…‚…‚Ž�@‚q‚�‚„‚‰‚�‚”‚‰‚�‚Ž�@‚�‚Ž‚„�@‚b‚�‚Ž‚ƒ‚…‚’�@‚h‚Ž‚„‚•‚ƒ‚…‚„�@‚‚‚™�@‚q‚…‚�‚…‚”‚‰‚”‚‰‚–‚…�@‚�‚’�@‚b‚�‚Ž‚”‚‰‚Ž‚•‚�‚•‚“�@‚h‚’‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž�h�@‚‰‚Ž�@‚e‚•‚‹‚•‚“‚ˆ‚‰‚�‚��@‚m‚•‚ƒ‚Œ‚…‚�‚’�@‚`‚ƒ‚ƒ‚‰‚„‚…‚Ž‚”�F‚f‚Œ‚�‚‚‚�‚Œ�@‚h‚�‚�‚Œ‚‰‚ƒ‚�‚”‚‰‚�‚Ž‚“�C‚k‚�‚Ž‚‡�|‚s‚…‚’‚��@‚g‚…‚�‚Œ‚”‚ˆ�@‚d‚†‚†‚…‚ƒ‚”‚“�@‚�‚Ž‚„�@‚d‚ƒ‚�‚Œ‚�‚‡‚‰‚ƒ‚�‚Œ�@‚b‚�‚Ž‚“‚…‚—‚•‚…‚Ž‚ƒ‚…‚“�@�i‚m‚�‚”‚•‚’‚�‚Œ�@‚c‚‰‚“‚�‚“‚”‚…‚’�@‚q‚…‚“‚…‚�‚’‚ƒ‚ˆ�C�@‚o‚’‚…‚„‚‰‚ƒ‚”‚‰‚�‚Ž�@‚�‚Ž‚„�@‚l‚‰‚”‚‰‚‡‚�‚”‚‰‚�‚Ž�j�C(‚r‚ˆ‚‰‚š‚•‚™‚��D‚r‚•‚”‚�‚•�@‚d‚„�D�j‚m‚�‚–‚��@‚r‚ƒ‚‰‚…‚Ž‚ƒ‚…�@‚o‚•‚‚�@‚h‚Ž‚ƒ�C�@‚m‚…‚—�@‚x‚�‚’‚‹�C�@‚b‚ˆ‚�‚�‚”‚…‚’‚X�C‚�‚�‚P‚T‚T�|‚P‚U‚U�C�i‚Q‚O‚P‚T�j

‚n‚ˆ‚‡‚•‚’‚‰�@‚s�C�@‚j‚•‚Ž‚•‚‡‚‰‚”‚��@‚m�C�@‚x‚�‚ˆ‚�‚’‚��@‚j�C�@‚h‚�‚�‚„‚��@‚g�C�@‚t‚…‚�‚•‚’‚��@‚g�C�@‚r‚ˆ‚‰‚Ž‚™‚��@‚m�C�@‚x‚�‚•‚Š‚‰‚’‚�‚•�@‚f�C�@‚s‚�‚‹‚�‚“‚‰�@‚b�C�@‚n‚‹‚�‚š‚�‚‹‚‰�@‚q�C�@‚n‚�‚”‚“‚•‚™‚�‚�‚��@‚`�C�@‚j‚�‚’‚�‚‡‚‰�@‚x�C�@‚d‚†‚†‚‰‚ƒ‚�‚ƒ‚™�@‚�‚†�@‚ˆ‚™‚�‚…‚’‚‚‚�‚’‚‰‚ƒ�@‚�‚˜‚™‚‡‚…‚Ž�@‚”‚ˆ‚…‚’‚�‚�‚™�@‚ƒ‚�‚�‚‚‚‰‚Ž‚…‚„�@‚—‚‰‚”‚ˆ�@‚�‚‰‚Œ‚„�@‚ˆ‚–‚�‚…‚’‚”‚ˆ‚…‚’‚�‚‰‚��@‚†‚�‚’�@‚‰‚�‚�‚’‚�‚–‚‰‚Ž‚‡�@‚™‚ˆ‚…�@‚�‚Ž‚”‚‰�|‚”‚•‚�‚�‚•‚’�@‚…‚†‚†‚…‚ƒ‚”‚“�@‚�‚†�@‚ƒ‚�‚’‚‚‚�‚�‚Œ‚�‚”‚‰‚Ž�D�C‚h‚Ž‚”�@‚i�@‚g‚™‚�‚…‚’‚”‚ˆ‚…‚’‚�‚‰‚��D�C�@‚R‚P�i‚U�j�F‚U‚S‚R�|‚W�D‚„‚�‚‰�F‚P‚O�D‚R‚P‚O‚X�^‚O‚Q‚U‚T‚U‚V‚R‚U�D‚Q‚O‚P‚T�D‚P‚O‚P‚T‚T‚W‚R‚Q�D�i‚Q‚O‚P‚T�j

‚j‚�‚š‚�‚‹‚‰�@‚l�C�@‚n‚�‚”‚“‚•‚™‚�‚�‚��@‚`�C�@‚l‚�‚’‚‰‚”‚�‚‹‚…�@‚s�C�@‚`‚‚‚…�@‚s�C�@‚n‚‹‚�‚š‚�‚‹‚‰�@‚q�C�@‚v‚ˆ‚�‚”�@‚ˆ‚�‚–‚…�@‚—‚…
‚Œ‚…‚�‚’‚Ž‚…‚„�@‚†‚’‚�‚��@‚��@‚‘‚•‚…‚“‚”‚‰‚�‚ނނ�‚‰‚’‚…�@‚“‚•‚’‚–‚…‚™�@‚�‚�‚†�@‚ƒ‚‰‚”‚‰‚š‚…‚Ž‚“�@‚�‚Ž‚„�@‚„‚�‚ƒ‚”‚�‚’‚“�@‚‚‚�‚”‚ˆ�@‚‰‚Ž‚“‚‰‚„‚…�@
‚�‚Ž‚„�@‚�‚•‚“‚‰‚„‚…�@‚e‚•‚‹‚•‚“‚ˆ‚‰‚�‚��H�F�@‚“‚•‚’‚–‚…‚™�@‚ƒ‚�‚�‚�‚�‚’‚‰‚“‚�‚Ž�@‚‚‚…‚”‚—‚…‚…‚Ž�@‚Q‚O‚P‚P�@‚�‚Ž‚„�@‚Q‚O‚P‚R�D�C‚i�@‚q‚�‚„‚‰‚�‚Œ�@‚o‚’‚�‚”�D�C35(1)�F‚m‚P�|‚P‚V�D‚„‚�‚‰�F‚P‚O�D‚P‚O‚W‚W�^‚O‚X‚T‚Q�|‚S‚V‚S‚U�^‚R‚T�^‚P�^‚m‚P�i‚Q‚O‚P‚T�j
�@
‚n‚ˆ‚”‚�‚Ž‚‰�@‚r�C�@‚t‚“‚ˆ‚‰‚™‚�‚�‚��@‚`�C�@‚n‚�‚”‚“‚•‚™‚�‚�‚��@‚`�C�@‚j‚•‚Ž‚•‚‡‚‰‚”‚��@‚m�C�@‚o‚…‚’‚“‚‰‚“‚”‚…‚Ž‚ƒ‚…�@‚�‚†�@‚’‚…‚„�@‚‚‚Œ‚�‚�‚„�@‚ƒ‚…‚Œ‚Œ‚“�@‚—‚‰‚”‚ˆ�@‚o‚‰‚‡�|‚��@‚�‚•‚”‚�‚”‚‰‚�‚Ž�@‚‰‚Ž�@‚�‚T‚R�@‚‹‚Ž‚�‚ƒ‚‹‚�‚•‚”�@‚�‚‰‚ƒ‚…�@‚…‚˜‚�‚�‚“‚…‚„�@‚”‚��@‚w�|‚‰‚’‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž�D�C�@‚i�@‚s‚�‚˜‚‰‚ƒ‚�‚Œ�@‚r‚ƒ‚‰�D�C�@‚R‚X�@�F‚V�|‚P‚S�D�i‚Q‚O‚P‚S�j

‚n‚�‚”‚“‚•‚™‚�‚�‚��@‚`�C‚q‚…‚“‚�‚�‚Ž‚“‚…�@‚�‚†�@‚”‚ˆ‚…�@‚“‚‹‚‰‚Ž�@‚”‚��@‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž�D�C‚q‚�‚„‚‰‚�‚”�D‚a‚‰‚�‚Œ�D‚q‚…‚“�D‚b‚�‚��D�C‚S‚X�@�F�@‚P‚X‚W�|‚Q‚P‚O�D(2014)

Cao L, Kwai H, Sasatani M, Iizuka D, Masuda Y, Inada T, Suzuki K, Ootsuyama A, Umata T, Kamiya K, A Novel ATM/TP53/p21-Medated Checkpoint Only Activated by Chronic ƒÁ�|‚h‚’‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž�D�C‚o‚k‚�‚“�@‚n‚Ž‚…�D�C9�F‚…‚P‚O‚S‚Q‚V‚X�D�i‚Q‚O‚P‚S�j

Okazaki R, Ootsuyama A, p53-dependent delayed effects of radiation vary according to time of irradiation of p53+/-mice. J Radiat Res., 55(1):25-31.,doi:10.1093/jrr/rrt083.(2014)

‘å’ÃŽR�@�²�A‰ªú±�@—´Žj�A’–Žë�@˜a”V�APig-Aˆâ“`Žq‚ðƒŠƒ|�[ƒ^�[‚Æ‚µ‚Ä—p‚¢‚½in�@vibo“Ë‘R•ψٌŸ�oŽŽŒ±‚Ì�‚�ü—ʔ픘ŠÂ‹«�ì‹ÆŽÒ‚ÌŒ’�N‰e‹¿•]‰¿‘Ήž‚Ö‚ÌŒŸ“¢‡U�A‘æ‚R‚Q‰ñŽY‹Æˆã‰È‘åŠwŠw‰ï�A–k‹ã�B�A‚P‚OŒŽ‚S“ú�A‚Q‚O‚P‚S

A�@novel�@ATM/TP‚T‚R/‚�21-mediated�@checkpoint�@‚�‚Ž‚Œ‚™�@‚�‚ƒ‚”‚‰‚–‚�‚”‚…‚„�@‚‚‚™�@‚ƒ‚ˆ‚’‚�‚Ž‚‰‚ƒ�@ƒÁ-‚‰‚’‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž�D�@‚b‚�‚��@‚k�C‚j‚�‚—‚�‚‰�@‚g�C‚r‚�‚“‚�‚”‚�‚Ž‚‰�@‚l�C‚h‚‰‚š‚•‚‹‚��@‚c�C‚l‚�‚“‚•‚„‚��@‚x�C‚h‚Ž‚�‚„‚��@‚s�C‚r‚•‚š‚•‚‹‚‰�@‚j�C‚n‚•‚”s‚•‚™‚�‚�‚�‚`�C‚t‚�‚�‚”‚��@‚s�C‚j‚�‚�‚‰‚™‚��C‚j�C‚r‚•‚š‚•‚‹‚‰�@‚e�D
‚o‚k‚�‚r�@‚n‚Ž‚…�D2014‚`‚•‚‡‚T�G‚X�i‚W�j�F‚…104279�D‚„‚�‚‰�F10�D1371/‚Š‚�‚•‚’‚Ž‚�‚Œ�D‚�‚�‚Ž‚…�D0104279�D‚…‚b‚�‚Œ‚Œ‚…‚ƒ‚”‚‰‚�‚Ž2014�D�@

Persistence of red blood cells with Pig-a mutation in p53 knockout mice exposed to X-irradiation.
Ohtani S�C Ushiyama A�C Ootsuyama A�C Kunugita N�D
J Toxicol Sci. 2014Fe�G;39(1)�F7-14.

p53-dependent delayed effects of radiation ‚–‚�‚’‚™ ‚�‚ƒ‚ƒ‚�‚’‚„‚‰‚Ž‚‡ ‚”‚� ‚”‚‰‚�‚… ‚�‚† ‚‰‚’‚’‚�‚„‚‰‚�‚”‚‰‚�‚Ž ‚�‚† p53+/-mice�D
Okazaki R�C Ootsuyama A�D
J Radiat Res�D2014 Jan 1�G55�i1�j�F25-31�D‚„‚�‚‰�F10�D1093/‚Š‚’‚’/‚’‚’‚”083�D‚d‚�‚•‚‚ 2013 ‚i‚•‚Ž 13�D

What have we learned from a questionnaire survey of citizens and doctors both inside and outside Fukushima�H�Fsurvey comparison between 2011and 2013�D
Kohzaki M�COotsuyama A�CMoritake T�CAbe T�CKubo T�COkazaki R�D
J Radio Prot�D2015 Mar�G35�i1�j�FN1-N17�Ddoi�F10�D1088/0952-4746/35/1/N1�DEpub 2015 Jan �@12�D�@�@�@

Yamaguchi Y, Miyata H, Uchiyama K, Ootsuyama A, Inubushi S, Mori T, Muramatsu N, Katamine S, Sakaguchi S: Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions.  PLoS One. 2012;7(8):e43540. Epub 2012 Aug 21.

 
Kawai K, Li Yun-shan, Song Ming-fen, Ootsuyama Y, Kakehashi A, Waibuchi H, Ootsuyama A, Norimura T, Kasai H: Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse: Possible Role of Free Radical-mediated DNA Methylation.. Genes Environ. 2012 34(3):123-128.


Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S : Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions.  .  Cell Mol Neurobiol. 2011 Oct;31(7):999-1008. Epub 2011 Apr 23.

 

He D, Uehara Y, Furuya M, Ikehata H, Komura J, Yamauchi K, Kakinuma S, Shang Y, Shimada Y, Ootsuyama A, Norimura T, Ono T : Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice.  Mech Ageing Dev. 2011 Mar;132(3):117-22. Epub 2011 Feb 12.


‘å’ÃŽR�@�²�F•úŽË�ü”픘‚Æ�l‘Ì‚T�j•úŽË�ü‚َ̑™‚ւ̉e‹¿�ABio Clinica,27�i5�j,444-448�i2012�j

‰ªú±�@—´Žj�A‘å’ÃŽR�@�²�Aˆ¢•”�@—˜–¾�A‹v•Û�@’B•F�F•Ÿ“‡Œ§“àŠO‚̈ê”ÊŽs–¯‚¨‚æ‚шãŽt‚Ì•Ÿ“‡‘æˆêŒ´Žq—Í”­“d�ŠŽ–ŒÌŒã‚Ì•úŽË�ü”픘‚ɑ΂·‚éˆÓޝ’²�¸�AJ UOEH�iŽY‹Æˆã‰È‘åŠwŽGŽ��jVol�D34 No�D1 ‚�91-105�i2012�j

‰ªú±�@—´Žj�A‘å’ÃŽR�@�²�Aˆ¢•”�@—˜–¾�A‹v•Û�@’B•F�A‘¾�_�@˜aœA�A‹e’r�@’C•v�A‹e’r�@�M‘¾˜Y�A�²‹vŠÔ�@�G�l�FŒSŽRŽs“àˆãŽt‚ƈê”ÊŽs–¯‚Ì•Ÿ“‡‘æˆêŒ´”­Ž–ŒÌŒã‚Ì•úŽË�ü‚ɑ΂·‚éˆÓޝ‚̈Ⴂ�iƒAƒ“ƒP�[ƒg’²�¸Œ‹‰Ê‚©‚ç�j�A•Ÿ‰ªˆãŽt‰ï•ñ�@‘æ‚V‚RŠª�@‘æ‚P‚Q�†�@‚�38-41�i2011�j

Okazaki, R., Ootsuyama, A., Kakihara, H., Mabuchi, Y., Matsuzaki, Y., Michikawa, Y., Imai, T., Norimura, T.�F Dynamics of delayed p53 mutations in mice given whole-body irradiation at 8 weeks , Int. J. Radiation Oncology Biol. Phys, 79(1):247-254(2011)


Okazaki R, Ootsuyama A, Yoshida Y, Norimura T : Establishment of Methylation-Specific PCR for the Mouse p53 Gene. .  Mol Biol Int. 2011;2011:938435. Epub 2011 Dec 12.


‘å’ÃŽR�@�²�A‰ªú±�@—´Žj�A–@‘º�@�r”V�F‚�‚T‚Rˆâ“`Žqƒnƒvƒ�•s‘S‚Ì”­‚ª‚ñ‰ß’ö‚Ö‚ÌŠÖ—^�A•úŽË�ü�¶•¨Œ¤‹†�@45�i4�j:396-407 (2010)


Okazaki R, Mabuchi Y, Yoshida Y, Suzuki S, Ding N, Matsuzaki Y, Ootsuyama A, Norimura T : The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice.    Int J Radiat Biol. 2010 Nov;86(11):927-34. Epub 2010 Aug 2.


Okazaki, R. , Mabuchi, Y. , Yoshida, Y. , Suzuki, S. , ‚cing, ‚m. , Matsuzaki, Y. , Ootsuyama, A. , Norimura, T. : The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice, Int. J. Radiat. Biol., 86(11):927-934(2010)

Okudaira, N. , Uehara, Y. , Fujikawa, K. , Kagawa, N. , Ootsuyama, A. , Norimura, T. , Saeki, K. , Nohmi, T. , Matumura, K. , Matsumoto, T. , Oghiso, Y. , Tanaka, K. , Ichinohe, K. , Nakamura, S. , Tanaka, S. , Ono, T. : Radiation Dose-Rate Effect on Mutation Induction in Spleen and Liver of gpt delta Mice, Radiation Research, 173(2):138-147(2010)

Tanooka, H., Tatsumi, K., Tsuji, H., Noda, Y., Katsube, T., Ishii, H., Ootsuyama, A.,
Takeshita, F. and Ochiya, T. :Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA, Cancer Gene Therapy, 17: 1-10 (2010)

‰ªú±�@—´Žj�A‘å’ÃŽR�@�²�A–@‘º�@�r”V�F˜V‰»‚̃gƒsƒbƒNƒX�[ƒeƒ�ƒ�ƒA�Aƒ~ƒgƒRƒ“ƒhƒŠƒA�A‚�53�@•úŽË�ü�¶•¨Œ¤‹†�@44�i2�j:127-139�i2009�j

‰ªú±—´Žj�A’–Žë˜a”V�AŠ`Œ´‚Ђë‘ã�A‘å’ÃŽR�²�A–@‘º�r”V�F•úŽË�ü”픘‚É‚æ‚é’x‰„Œ^“Ë‘R•ψقɂ¨‚¯‚é‚�‚T‚Rˆâ“`Žq‚̉ð�Í�@‚Š�@UOEH�@O‚ƒ‚ƒ‚•‚��@‚d‚Ž‚–‚‰‚’‚�‚Ž�@‚g‚…‚�‚Œ‚”‚ˆ�D2008�D30�i‚P�j�D120

Igari, Y., Igari, K., Kunugita, N., Ootsuyama, A., Norimura, T.: Prolonged Increase in T-Cell Receptor(TCR) Variant Fractions of Spleen T Lymphocytes in Pregnant Mice after gamma Irradiation. Radiat. Res.,168(1):81-86(2007)

Okazaki , R., Ootsuyama, A., Norimura, T.: TP53 and TP53-Related Genes Associated with Protection from Apoptosis in the Radioadaptive Response. Radiat. Res. 167(1):51-57(2007)

‘å’ÃŽR�²�@�F�@ˆãŠw�‘‰@ˆãŠw‘厫“T�i‘æ‚Q”Å�j�AˆãŠw�‘‰@�A2007�A‚P‚T�€–ÚŽ·•M

Igari, K., Igari, Y., Okazaki , R., Kato, F., Ootsuyama, A., Norimura, T.: The Delayed Manifestation of T-cell Receptor (TCR) Variants in X-irradiated Mice Depends on Trp 53 Status. Radiat. Res., 166(1):55-60(2006)

�²“n•q•F�A•Ÿ“‡�ºŽ¡�A�b”ã—Ï–¾�@�F•úŽË�ü‚¨‚æ‚ъ‹«‰»Šw•¨Ž¿‚É‚æ‚é”­‚ª‚ñ�[–{“–‚É”÷—ʂłàŠëŒ¯‚Ȃ̂©�H�|�Aˆã—ÉȊwŽÐ�A2005�D12�A‹¤“¯Ž·•M

Okazaki , R., Ootsuyama, A., Norimura, T.: Radioadaptive Response for Protection against Radiation-Induced Teratogenesis. Radiat. Res.,163(3):266-270(2005)

‘å’ÃŽR�²�@:�@•úŽË�ü—U”­‚ÆŽv‚í‚ê‚é“Ë‘R•ψق̃XƒyƒNƒgƒ‹‚ɂ‚¢‚Ä�D•úŽË�ü�¶•¨Œ¤‹†�D2005�D40.�i3�j�D270�|281�D

Igari Y, Igari K, Kakihara H, Kato F, Ootsuyama A, Norimura T :Increases radiosensitivity of splenic T lymphocytes in pregnant mice. Int. Cong. Series(ICS) 1276, 2005, 183-4.

Igari K, Igari Y, Kakihara H, Kato F, Ootsuyama A, Norimura T :Role of p53 gene in genetic instability induced by ionizing radiation. Int. Cong. Series(ICS) 1276, 2005, 262-3.

’–Žë˜a”V�A‹e’r‰›�A‰Á“¡•¶—Y�A‘å’ÃŽR�²�A–@‘º�r”V�F–^Šé‹Æ‚É‚¨‚¯‚é”í‚΂­ˆã—ÑÌ�§‚Ì�\’z�AJ�@UOEH�@Occup�@Environ�@Health�D2004.26�i1�j�D138

Okazaki , R., Sakai , A., Ootsuyama, A., Sakata, T., Nakamura, T., Norimura, T.: Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice. Ann. Rheum. Dis., 63(4):453-456(2004)

‰Á“¡•¶—Y�A‘å’ÃŽR�²�A–@‘º�r”V�Fƒ}ƒEƒX‘ÙŽeŽå—vŠíНŒ`�¬Šú‚É‚¨‚¯‚é•úŽË�ü—U”­“Ë‘R•ψق̉ð�Í�Aj�@UOEH�@Occuo�@Environ�@Health�D2003�D25.�i1�j�D139.

Ootsuyama, A., Okazaki , R., Norimura, T.: Effect of exposure to low-dose rate radiation on autoimmune diseases of immunologically suppressed MRL/MpTn-gld/gld mice. J. Radiat. Res., (44):243-247(2003)


‰ªú±—´Žj�A‘å’ÃŽR�²�A“à“c�@Žu�A–@‘º�r”V�F‚S�D‚VT’è�펥�ê‚Ì�ÊïŒ`�«‚È‚ç‚Ñ‚É�œ“î�œ‘ãŽÓ‚ւ̉e‹¿�D‚Š�@UOEH�@Environ�@Health�D2002�D24�i1�j�D94.

Tanaka, K., Ootsuyama, A., Tanooka, H. & Ansell, J. D.: Test for fused-cell origin of tumors with Mus caroli carrying glucose-6-phosphate dehydrogenase cellular mosaicism. Onc. Rep. 7 : 897-898 (2000)

‰ªú±—´Žj�AŽðˆä�º“T�A‘å’ÃŽR�²�A�â“c•�Žu�A’†‘º—˜�F�F•GŠÖ�ߌŒè‚É‚æ‚é�œ“î�œ‚̃Aƒ|ƒg�[ƒVƒX‚ɂ͂�‚T‚R‚ªŠÖ—^‚·‚é�D“ú–{�®Œ`ŠO‰ÈŠw‰ïŽGŽ��D2000�D74�D�i8�j�DS1683�D

‰ªú±—´Žj�A‘å’ÃŽR�²�A‰Á“¡•¶—Y�A–@‘º�r”V�FŽ©ŒÈ–Ɖu•aƒ}ƒEƒX‚Ì•úŽË�ü�Ǝ˂ɂæ‚鉊�ÇŒyŒ¸Œø‰Ê‚ƃAƒ|ƒg�[ƒVƒX‚ÌŠÖŒW�DJ�@UOEH�@Occup�@Environ�@Health�D2000�D22�i1�j�D76�D

‰Á“¡•¶—Y�A‘å’ÃŽR�²�A–쌳˜_�A–@‘º�r”V�@�Fp‚T‚R‚É‚æ‚é•úŽË�ü—U”­�Êï�«�áŠQ‚Ì–hŒä‹@�\�D�@•úŽË�ü�¶•¨Œ¤‹†�D2000�D35�D�i3�j�D226�|236

Tanooka, H., Ootsuyama, A., & Sasaki, H.: Homologaous reconbination between p53 and its pseudogene in a radiation-induced mouse tumor. Cancer Res. 58 : 5649-5651 (1998)

Nomoto, S., Ootsuyama, A., Shioyama, Y., Katsuki, M., Kondo, S. & Norimura, T.: The high susceptibility of heterozygous p53(+/-) mice to malformation after foetal irradiation is related to sub-component apoptosis. Int. J. Radiat. Biol. 74 : 419-429 (1998)

�²“n•q•F�A“‡“c‹`–ç�A�´�…—R‹IŽq�A‘å’ÃŽR�²�@�F•úŽË�ü”­‚ª‚ñ‚ÉŠÖ‚·‚é臒l–â‘è‚ÌŒŸ“¢�A�k•úŽË�ü”­‚ª‚ñ‚ÉŠÖ‚·‚é臒l–â‘茟“¢‰ï•Ò�l�AŒ´Žq—͈À‘SŒ¤‹†‹¦‰ï�A1997�D3�@‚�‚�25�|57

Mei, N., Kunugita, N., Nomoto, S., Ootsuyama, A. & Norimura, T.: Influence of doner age on the cytotoxicity and mutagenicity of ethylnitrosourea in cultured human T-lymphocytes. J. UOEH 19 : 133-145 (1997)

Ootsuyama, A.: Skin and bone tumors induced by repeated beta-iradiation of mice: Threshold effect and p53 mutations. J. Radiat. Res. 37 : 151-159 (1996)

Ohira, M., Ootsuyama, A., Suzuki, E., Ichikawa , H., Seki, N., Nagase, T., Nomura, N. & Ohki, M.: Identification of a novel human gene containing the tetratricopeptide repeat domain from the down syndrome region of chromosome 21. DNA Res. 3 : 9-16 (1996)


–쌳˜_�A‘å’ÃŽR�²�A–@‘º�r”V�@�F�Êï�«�áŠQ–hŒä‚É‚¨‚¯‚é‚�53Šà—}�§ˆâ“`Žq‚Ì–ðŠ„�@p‚T‚RˆË‘¶�«ƒAƒ|ƒg�[ƒVƒX‚É‚æ‚é‘Ù‰èŠú‚Ì�áŠQ‹@�\‚ɂ‚¢‚Ä�D1996�D31�i4�j�D302�|310

‘å’ÃŽR�²�@�FƒÀ�ü”½•œ�Ǝ˂ɂæ‚éƒ}ƒEƒX”畆”­‚ª‚ñ�G•úŽË�ü”­‚ª‚ñ‚É‚¨‚¯‚邵‚«‚¢’l—lŒ»�Û‚ÌŠm”F‚È‚ç‚тɕúŽË�ü—U”­Žî‚悤‚É‚¨‚¯‚ép‚T‚Rˆâ“`Žq•ψق̉ð�Í�D•úŽË�ü�¶•¨Œ¤‹†�D1996�D31�i2�j�D107�|119

‘å’ÃŽR�²�@�FƒÀ�ü”½•œ�Ǝ˂ɂæ‚éŽîᇔ­�¶‚ÉŠÖ‚·‚é�ü—Ê�[Œø‰ÊŠÖŒW�A•úŽË�ü”­Šà‚É‚µ‚«‚¢’l‚Í‘¶�Ý‚·‚é‚©�Dƒ�ƒfƒBƒJƒ‹�EƒgƒsƒbƒNƒX�D1995�D22�D36�|37

Tanooka H, Ootsuyama A�@�F�@Non-linear threshold dose response of murine tumorigenesis by repeated beta-irradiation and p53 mutations involved. Radat.Res. Cong. Proc., Vol.2, 1995, 693-6.

Tanooka, H., Ootsuyama, A., Shiroishi, T. & Moriwaki, K.: Distribution of the p53 pseudogene among mouse species and subspecies. Mammalian Genome 6 : 360-362 (1995)

Ootsuyama, A., Nagao, M., Makino, H., Ochiai, A., Yamauchi, Y. & Tanooka, H.: Frequent p53 mutation in mouse tumors induced by repeated beta irradiation. Mol. Carcinogenesis 11 : 236-242 (1994)

Sato F�AWatanabe�@M�AKosako�@T,�@Ootsuyama�@A�@�F’á�ü—Ê•úŽË�ü‚ÆŒ’�N‰e‹¿�[‹^–â‚É“š‚¦‚Ä�[�A�k”÷—Ê•úŽË�ü‰e‹¿ŒŸ“¢�ê–åˆÏˆõ‰ï•Ò�l�AŒ´Žq—͈À‘SŒ¤‹†‹¦‰ï�A1994�D3�@‚�‚�21�|30

‘å’ÃŽR�²�@�FƒÀ�ü”½•œ�Ǝ˂ɂæ‚éŽî‚悤”­�¶‚ÉŠÖ‚·‚é�ü—Ê�[Œø‰ÊŠÖŒW�@•úŽË�ü”­Šà‚É‚µ‚«‚¢’l‚Í‘¶�Ý‚·‚é‚©�DˆãŠw‚Ì‚ ‚ä‚Ý�D1994�D171�i11�j�D882�|883


‘å’ÃŽR�²�A“cƒm‰ª�G�A’·”ö”ü“ÞŽq�A–q–ì�_Ži :ƒqƒg�Eƒ}ƒEƒX�EƒQƒmƒ€‰ð�ÍŒ¤‹†‚Æ•úŽË�ü�¶•¨Šw IV.•úŽË�ü”­‚ª‚ñ‚̃Qƒmƒ€•ψ٠1.•úŽË�ü”½•œ�Ǝ˂ɂæ‚Á‚Ä—U”­‚³‚ꂽƒ}ƒEƒXŽî‚悤‚Ìp53ˆâ“`Žq‚̕ω». �A NIRS?M (Natl Inst Radiol Sci). 1994. 97. 93-98.

‘å’ÃŽR�²�A“cƒm‰ª�G :•úŽË�ü”­‚ª‚ñ‚Æ‚»‚Ì�§Œä ‹@�\‰ð–¾‚ւ̃Aƒvƒ��[ƒ` I�F ŽÀŒ±“I”­‚ª‚ñ 2�F ƒx�[ƒ^�ü”½•œ�Ǝ˂ɂæ‚éƒ}ƒEƒX”畆”­‚ª‚ñ‚Ì‚µ‚«‚¢’l�ü—Ê(Radiation carcinogenesis and its control. Approaches to mechanism elucidation. Threshold-like dose response of skin carcinogenesis by repeated beta irradiation in mice). 1993. NIRS?M (Natl Inst Radiol Sci). p94. 14-20.

Ootsuyama, A. & Tanooka, H.: Effect of inhibitor of tumor promotion, a-difluolomethyl-ornithine,on tumor induction by repeated beta irradiation in mice. Jpn. J. Cancer Res. 84 : 34-36 (1993)

Ootsuyama, A. & Tanooka, H.: Zero tumor incidence in mice after repeated lifetime exposures to 0.5 Gy of beta radiation. Radiat. Res. 134 : 244-246 (1993)

Tanooka, H. & Ootsuyama, A.: Threshold-like dose response of mouse skin cancer induction by repeated beta irradiation and its relevance to radiation-induced human skin cancer. Resent Results in Cancer Res. 128 : 231-241 (1993)

Ootsuyama, A., Tanaka, K. & Tanooka, H.: Clonal origin of skin and bone tumors produced by repeated beta-irradiation in mosaic cell mice. Jpn. J. Cancer Res. 83 : 964-967 (1992)

Finch, J., Andrews, K., Slaga, T., Ootsuyama, A., Tanooka, H. et al: Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin. Carcinogenesis 12 : 1519-1522 (1991)

Tanooka, H. & Ootsuyama, A.: Radiation carcinogenesis in mouse skin and its threshold- like response. J. Radiat. Res. Supple 2 32 : 195-201 (1991)

Ootsuyama, A. & Tanooka, H.: Threshold-like dose of local beta irradiation repeated throughout the life span of mice for induction of skin and bone tumors. Radiat. Res. 125 : 98-101 (1991)

Fujiki H, Suganuma M, Suguri H, Ootsuyama A�@�FNew antitumor promoters: (-)-epigallocatecine gallate and sarcophytols A and B. In Antimutagenesis and anticarcinogenesis mechanisms II, Edited by Yukiaki Kuroda, Delbert M. Shankel, and Michael D. Waters,�@Basic life sciences, v. 52�@, Plenum Press, c. 1990 pp205-212

‘å’ÃŽR�²�@�F•úŽË�ü”½•œ�Ǝ˂ɂæ‚éƒ}ƒEƒX”畆Šà‚Ì—U”­. ˆãŠw‚Ì‚ ‚ä‚Ý. 1990. 153(5). 260.

�²“¡�Ý�A‘å’ÃŽR�²�A“cƒm‰ª�G�@�F•úŽË�üŠ´Žó�«‚Ì—\‘ª II �t”í–Œ‰ºˆÚ�AŠ´Žó�«ŽŽŒ±(Subrenal capsule assay applied to prediction of tumor radiosensitivity)�A Šà‚Ì—Õ�°�A1989. 35. p13. 1576-1580.

Ootsuyama, A. & Tanooka, H.: Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation. Cancer Res. 49 : 1562-1564 (1989)

Takagi N, Ootsuyama A, Tanooka H�@�FCytological evidence for single-cell origin of tumors induced with 3-methylcholanthrene in female mice carrying Cattanach's translocation. . Jpn J Cancer Res. 1986 Apr;77(4):376-84.

Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H�@�FFormation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986 Nov;7(11):1849-51.

 

Tanaka K, Ootsuyama A, Tanooka H�@�FClonal origin of spontaneous multiple mammary tumors in mice with cellular mosaicism.

. Gann. 1984 Sep;75(9):792-7.



4. “ú–{•úŽË�ü‰e‹¿Šw‰ï, “ú–{ŠàŠw‰ï, “ú–{�bˆãŠw‰ï, ‚»‚Ì‘¼

�£‘Oƒy�[ƒW‚É–ß‚é

�m•¶�Ó�F•úŽË�ü‰q�¶Šw�u�À�@ �X�V“ú�F2011.12.26�n