1. ‘å’ÃŽR@² (bˆãŠw”ŽŽm)

2. •úŽËü¶•¨Šw, ”­Šà, ƒAƒ|ƒg[ƒVƒX, ŽÀŒ±“®•¨

3. Œ¤‹†‹ÆÑ

‚n‚‚”‚“‚•‚™‚‚‚@‚`Dh‚c‚‚“‚…|‚d‚†‚†‚…‚ƒ‚”@‚q‚…‚Œ‚‚”‚‰‚‚Ž‚“‚ˆ‚‰‚@‚‚‚…‚”‚—‚…‚…‚Ž@‚q‚‚„‚‰‚‚”‚‰‚‚Ž@‚‚Ž‚„@‚b‚‚Ž‚ƒ‚…‚’@‚h‚Ž‚„‚•‚ƒ‚…‚„@‚‚‚™@‚q‚…‚‚…‚”‚‰‚”‚‰‚–‚…@‚‚’@‚b‚‚Ž‚”‚‰‚Ž‚•‚‚•‚“@‚h‚’‚’‚‚„‚‰‚‚”‚‰‚‚Žh@‚‰‚Ž@‚e‚•‚‹‚•‚“‚ˆ‚‰‚‚@‚m‚•‚ƒ‚Œ‚…‚‚’@‚`‚ƒ‚ƒ‚‰‚„‚…‚Ž‚”F‚f‚Œ‚‚‚‚‚Œ@‚h‚‚‚Œ‚‰‚ƒ‚‚”‚‰‚‚Ž‚“C‚k‚‚Ž‚‡|‚s‚…‚’‚@‚g‚…‚‚Œ‚”‚ˆ@‚d‚†‚†‚…‚ƒ‚”‚“@‚‚Ž‚„@‚d‚ƒ‚‚Œ‚‚‡‚‰‚ƒ‚‚Œ@‚b‚‚Ž‚“‚…‚—‚•‚…‚Ž‚ƒ‚…‚“@i‚m‚‚”‚•‚’‚‚Œ@‚c‚‰‚“‚‚“‚”‚…‚’@‚q‚…‚“‚…‚‚’‚ƒ‚ˆC@‚o‚’‚…‚„‚‰‚ƒ‚”‚‰‚‚Ž@‚‚Ž‚„@‚l‚‰‚”‚‰‚‡‚‚”‚‰‚‚ŽjC(‚r‚ˆ‚‰‚š‚•‚™‚D‚r‚•‚”‚‚•@‚d‚„Dj‚m‚‚–‚@‚r‚ƒ‚‰‚…‚Ž‚ƒ‚…@‚o‚•‚‚@‚h‚Ž‚ƒC@‚m‚…‚—@‚x‚‚’‚‹C@‚b‚ˆ‚‚‚”‚…‚’‚XC‚‚‚P‚T‚T|‚P‚U‚UCi‚Q‚O‚P‚Tj

‚n‚ˆ‚‡‚•‚’‚‰@‚sC@‚j‚•‚Ž‚•‚‡‚‰‚”‚@‚mC@‚x‚‚ˆ‚‚’‚@‚jC@‚h‚‚‚„‚@‚gC@‚t‚…‚‚•‚’‚@‚gC@‚r‚ˆ‚‰‚Ž‚™‚@‚mC@‚x‚‚•‚Š‚‰‚’‚‚•@‚fC@‚s‚‚‹‚‚“‚‰@‚bC@‚n‚‹‚‚š‚‚‹‚‰@‚qC@‚n‚‚”‚“‚•‚™‚‚‚@‚`C@‚j‚‚’‚‚‡‚‰@‚xC@‚d‚†‚†‚‰‚ƒ‚‚ƒ‚™@‚‚†@‚ˆ‚™‚‚…‚’‚‚‚‚’‚‰‚ƒ@‚‚˜‚™‚‡‚…‚Ž@‚”‚ˆ‚…‚’‚‚‚™@‚ƒ‚‚‚‚‚‰‚Ž‚…‚„@‚—‚‰‚”‚ˆ@‚‚‰‚Œ‚„@‚ˆ‚–‚‚…‚’‚”‚ˆ‚…‚’‚‚‰‚@‚†‚‚’@‚‰‚‚‚’‚‚–‚‰‚Ž‚‡@‚™‚ˆ‚…@‚‚Ž‚”‚‰|‚”‚•‚‚‚•‚’@‚…‚†‚†‚…‚ƒ‚”‚“@‚‚†@‚ƒ‚‚’‚‚‚‚‚Œ‚‚”‚‰‚ŽDC‚h‚Ž‚”@‚i@‚g‚™‚‚…‚’‚”‚ˆ‚…‚’‚‚‰‚DC@‚R‚Pi‚UjF‚U‚S‚R|‚WD‚„‚‚‰F‚P‚OD‚R‚P‚O‚X^‚O‚Q‚U‚T‚U‚V‚R‚UD‚Q‚O‚P‚TD‚P‚O‚P‚T‚T‚W‚R‚QDi‚Q‚O‚P‚Tj

‚j‚‚š‚‚‹‚‰@‚lC@‚n‚‚”‚“‚•‚™‚‚‚@‚`C@‚l‚‚’‚‰‚”‚‚‹‚…@‚sC@‚`‚‚‚…@‚sC@‚n‚‹‚‚š‚‚‹‚‰@‚qC@‚v‚ˆ‚‚”@‚ˆ‚‚–‚…@‚—‚…
‚Œ‚…‚‚’‚Ž‚…‚„@‚†‚’‚‚@‚@‚‘‚•‚…‚“‚”‚‰‚‚Ž‚Ž‚‚‰‚’‚…@‚“‚•‚’‚–‚…‚™@‚‚‚†@‚ƒ‚‰‚”‚‰‚š‚…‚Ž‚“@‚‚Ž‚„@‚„‚‚ƒ‚”‚‚’‚“@‚‚‚‚”‚ˆ@‚‰‚Ž‚“‚‰‚„‚…@
‚‚Ž‚„@‚‚•‚“‚‰‚„‚…@‚e‚•‚‹‚•‚“‚ˆ‚‰‚‚HF@‚“‚•‚’‚–‚…‚™@‚ƒ‚‚‚‚‚’‚‰‚“‚‚Ž@‚‚‚…‚”‚—‚…‚…‚Ž@‚Q‚O‚P‚P@‚‚Ž‚„@‚Q‚O‚P‚RDC‚i@‚q‚‚„‚‰‚‚Œ@‚o‚’‚‚”DC35(1)F‚m‚P|‚P‚VD‚„‚‚‰F‚P‚OD‚P‚O‚W‚W^‚O‚X‚T‚Q|‚S‚V‚S‚U^‚R‚T^‚P^‚m‚Pi‚Q‚O‚P‚Tj
@
‚n‚ˆ‚”‚‚Ž‚‰@‚rC@‚t‚“‚ˆ‚‰‚™‚‚‚@‚`C@‚n‚‚”‚“‚•‚™‚‚‚@‚`C@‚j‚•‚Ž‚•‚‡‚‰‚”‚@‚mC@‚o‚…‚’‚“‚‰‚“‚”‚…‚Ž‚ƒ‚…@‚‚†@‚’‚…‚„@‚‚‚Œ‚‚‚„@‚ƒ‚…‚Œ‚Œ‚“@‚—‚‰‚”‚ˆ@‚o‚‰‚‡|‚@‚‚•‚”‚‚”‚‰‚‚Ž@‚‰‚Ž@‚‚T‚R@‚‹‚Ž‚‚ƒ‚‹‚‚•‚”@‚‚‰‚ƒ‚…@‚…‚˜‚‚‚“‚…‚„@‚”‚@‚w|‚‰‚’‚’‚‚„‚‰‚‚”‚‰‚‚ŽDC@‚i@‚s‚‚˜‚‰‚ƒ‚‚Œ@‚r‚ƒ‚‰DC@‚R‚X@F‚V|‚P‚SDi‚Q‚O‚P‚Sj

‚n‚‚”‚“‚•‚™‚‚‚@‚`C‚q‚…‚“‚‚‚Ž‚“‚…@‚‚†@‚”‚ˆ‚…@‚“‚‹‚‰‚Ž@‚”‚@‚’‚‚„‚‰‚‚”‚‰‚‚ŽDC‚q‚‚„‚‰‚‚”D‚a‚‰‚‚ŒD‚q‚…‚“D‚b‚‚DC‚S‚X@F@‚P‚X‚W|‚Q‚P‚OD(2014)

Cao L, Kwai H, Sasatani M, Iizuka D, Masuda Y, Inada T, Suzuki K, Ootsuyama A, Umata T, Kamiya K, A Novel ATM/TP53/p21-Medated Checkpoint Only Activated by Chronic ƒÁ|‚h‚’‚’‚‚„‚‰‚‚”‚‰‚‚ŽDC‚o‚k‚‚“@‚n‚Ž‚…DC9F‚…‚P‚O‚S‚Q‚V‚XDi‚Q‚O‚P‚Sj

Okazaki R, Ootsuyama A, p53-dependent delayed effects of radiation vary according to time of irradiation of p53+/-mice. J Radiat Res., 55(1):25-31.,doi:10.1093/jrr/rrt083.(2014)

‘å’ÃŽR@²A‰ªú±@—´ŽjA’–Žë@˜a”VAPig-Aˆâ“`Žq‚ðƒŠƒ|[ƒ^[‚Æ‚µ‚Ä—p‚¢‚½in@vibo“Ë‘R•ÏˆÙŒŸoŽŽŒ±‚̍‚ü—ʔ픘ŠÂ‹«ì‹ÆŽÒ‚ÌŒ’N‰e‹¿•]‰¿‘Ήž‚Ö‚ÌŒŸ“¢‡UA‘æ‚R‚Q‰ñŽY‹Æˆã‰È‘åŠwŠw‰ïA–k‹ãBA‚P‚OŒŽ‚S“úA‚Q‚O‚P‚S

A@novel@ATM/TP‚T‚R/‚21-mediated@checkpoint@‚‚Ž‚Œ‚™@‚‚ƒ‚”‚‰‚–‚‚”‚…‚„@‚‚‚™@‚ƒ‚ˆ‚’‚‚Ž‚‰‚ƒ@ƒÁ-‚‰‚’‚’‚‚„‚‰‚‚”‚‰‚‚ŽD@‚b‚‚@‚kC‚j‚‚—‚‚‰@‚gC‚r‚‚“‚‚”‚‚Ž‚‰@‚lC‚h‚‰‚š‚•‚‹‚@‚cC‚l‚‚“‚•‚„‚@‚xC‚h‚Ž‚‚„‚@‚sC‚r‚•‚š‚•‚‹‚‰@‚jC‚n‚•‚”s‚•‚™‚‚‚‚`C‚t‚‚‚”‚@‚sC‚j‚‚‚‰‚™‚C‚jC‚r‚•‚š‚•‚‹‚‰@‚eD
‚o‚k‚‚r@‚n‚Ž‚…D2014‚`‚•‚‡‚TG‚Xi‚WjF‚…104279D‚„‚‚‰F10D1371/‚Š‚‚•‚’‚Ž‚‚ŒD‚‚‚Ž‚…D0104279D‚…‚b‚‚Œ‚Œ‚…‚ƒ‚”‚‰‚‚Ž2014D@

Persistence of red blood cells with Pig-a mutation in p53 knockout mice exposed to X-irradiation.
Ohtani SC Ushiyama AC Ootsuyama AC Kunugita ND
J Toxicol Sci. 2014FeG;39(1)F7-14.

p53-dependent delayed effects of radiation ‚–‚‚’‚™ ‚‚ƒ‚ƒ‚‚’‚„‚‰‚Ž‚‡ ‚”‚ ‚”‚‰‚‚… ‚‚† ‚‰‚’‚’‚‚„‚‰‚‚”‚‰‚‚Ž ‚‚† p53+/-miceD
Okazaki RC Ootsuyama AD
J Radiat ResD2014 Jan 1G55i1jF25-31D‚„‚‚‰F10D1093/‚Š‚’‚’/‚’‚’‚”083D‚d‚‚•‚‚ 2013 ‚i‚•‚Ž 13D

What have we learned from a questionnaire survey of citizens and doctors both inside and outside FukushimaHFsurvey comparison between 2011and 2013D
Kohzaki MCOotsuyama ACMoritake TCAbe TCKubo TCOkazaki RD
J Radio ProtD2015 MarG35i1jFN1-N17DdoiF10D1088/0952-4746/35/1/N1DEpub 2015 Jan @12D@@@

Yamaguchi Y, Miyata H, Uchiyama K, Ootsuyama A, Inubushi S, Mori T, Muramatsu N, Katamine S, Sakaguchi S: Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions.  PLoS One. 2012;7(8):e43540. Epub 2012 Aug 21.

 
Kawai K, Li Yun-shan, Song Ming-fen, Ootsuyama Y, Kakehashi A, Waibuchi H, Ootsuyama A, Norimura T, Kasai H: Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse: Possible Role of Free Radical-mediated DNA Methylation.. Genes Environ. 2012 34(3):123-128.


Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S : Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions.  .  Cell Mol Neurobiol. 2011 Oct;31(7):999-1008. Epub 2011 Apr 23.

 

He D, Uehara Y, Furuya M, Ikehata H, Komura J, Yamauchi K, Kakinuma S, Shang Y, Shimada Y, Ootsuyama A, Norimura T, Ono T : Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice.  Mech Ageing Dev. 2011 Mar;132(3):117-22. Epub 2011 Feb 12.


‘å’ÃŽR@²F•úŽËü”픘‚Ɛl‘Ì‚Tj•úŽËü‚Ì‘ÙŽ™‚ւ̉e‹¿ABio Clinica,27i5j,444-448i2012j

‰ªú±@—´ŽjA‘å’ÃŽR@²Aˆ¢•”@—˜–¾A‹v•Û@’B•FF•Ÿ“‡Œ§“àŠO‚̈ê”ÊŽs–¯‚¨‚æ‚шãŽt‚Ì•Ÿ“‡‘æˆêŒ´Žq—Í”­“dŠŽ–ŒÌŒã‚Ì•úŽËü”픘‚ɑ΂·‚éˆÓŽ¯’²¸AJ UOEHiŽY‹Æˆã‰È‘åŠwŽGŽjVolD34 NoD1 ‚91-105i2012j

‰ªú±@—´ŽjA‘å’ÃŽR@²Aˆ¢•”@—˜–¾A‹v•Û@’B•FA‘¾_@˜aœAA‹e’r@’C•vA‹e’r@M‘¾˜YA²‹vŠÔ@GlFŒSŽRŽs“àˆãŽt‚ƈê”ÊŽs–¯‚Ì•Ÿ“‡‘æˆêŒ´”­Ž–ŒÌŒã‚Ì•úŽËü‚ɑ΂·‚éˆÓŽ¯‚̈ႢiƒAƒ“ƒP[ƒg’²¸Œ‹‰Ê‚©‚çjA•Ÿ‰ªˆãŽt‰ï•ñ@‘æ‚V‚RŠª@‘æ‚P‚Q†@‚38-41i2011j

Okazaki, R., Ootsuyama, A., Kakihara, H., Mabuchi, Y., Matsuzaki, Y., Michikawa, Y., Imai, T., Norimura, T.F Dynamics of delayed p53 mutations in mice given whole-body irradiation at 8 weeks , Int. J. Radiation Oncology Biol. Phys, 79(1):247-254(2011)


Okazaki R, Ootsuyama A, Yoshida Y, Norimura T : Establishment of Methylation-Specific PCR for the Mouse p53 Gene. .  Mol Biol Int. 2011;2011:938435. Epub 2011 Dec 12.


‘å’ÃŽR@²A‰ªú±@—´ŽjA–@‘º@r”VF‚‚T‚Rˆâ“`Žqƒnƒvƒ•s‘S‚Ì”­‚ª‚ñ‰ß’ö‚Ö‚ÌŠÖ—^A•úŽËü¶•¨Œ¤‹†@45i4j:396-407 (2010)


Okazaki R, Mabuchi Y, Yoshida Y, Suzuki S, Ding N, Matsuzaki Y, Ootsuyama A, Norimura T : The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice.    Int J Radiat Biol. 2010 Nov;86(11):927-34. Epub 2010 Aug 2.


Okazaki, R. , Mabuchi, Y. , Yoshida, Y. , Suzuki, S. , ‚cing, ‚m. , Matsuzaki, Y. , Ootsuyama, A. , Norimura, T. : The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice, Int. J. Radiat. Biol., 86(11):927-934(2010)

Okudaira, N. , Uehara, Y. , Fujikawa, K. , Kagawa, N. , Ootsuyama, A. , Norimura, T. , Saeki, K. , Nohmi, T. , Matumura, K. , Matsumoto, T. , Oghiso, Y. , Tanaka, K. , Ichinohe, K. , Nakamura, S. , Tanaka, S. , Ono, T. : Radiation Dose-Rate Effect on Mutation Induction in Spleen and Liver of gpt delta Mice, Radiation Research, 173(2):138-147(2010)

Tanooka, H., Tatsumi, K., Tsuji, H., Noda, Y., Katsube, T., Ishii, H., Ootsuyama, A.,
Takeshita, F. and Ochiya, T. :Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA, Cancer Gene Therapy, 17: 1-10 (2010)

‰ªú±@—´ŽjA‘å’ÃŽR@²A–@‘º@r”VF˜V‰»‚̃gƒsƒbƒNƒX[ƒeƒƒƒAAƒ~ƒgƒRƒ“ƒhƒŠƒAA‚53@•úŽËü¶•¨Œ¤‹†@44i2j:127-139i2009j

‰ªú±—´ŽjA’–Žë˜a”VAŠ`Œ´‚Ђë‘ãA‘å’ÃŽR²A–@‘ºr”VF•úŽËü”픘‚É‚æ‚é’x‰„Œ^“Ë‘R•ÏˆÙ‚É‚¨‚¯‚邐‚T‚Rˆâ“`Žq‚̉ðÍ@‚Š@UOEH@O‚ƒ‚ƒ‚•‚@‚d‚Ž‚–‚‰‚’‚‚Ž@‚g‚…‚‚Œ‚”‚ˆD2008D30i‚PjD120

Igari, Y., Igari, K., Kunugita, N., Ootsuyama, A., Norimura, T.: Prolonged Increase in T-Cell Receptor(TCR) Variant Fractions of Spleen T Lymphocytes in Pregnant Mice after gamma Irradiation. Radiat. Res.,168(1):81-86(2007)

Okazaki , R., Ootsuyama, A., Norimura, T.: TP53 and TP53-Related Genes Associated with Protection from Apoptosis in the Radioadaptive Response. Radiat. Res. 167(1):51-57(2007)

‘å’ÃŽR²@F@ˆãŠw‘‰@ˆãŠw‘厫“Ti‘æ‚Q”ŁjAˆãŠw‘‰@A2007A‚P‚T€–ÚŽ·•M

Igari, K., Igari, Y., Okazaki , R., Kato, F., Ootsuyama, A., Norimura, T.: The Delayed Manifestation of T-cell Receptor (TCR) Variants in X-irradiated Mice Depends on Trp 53 Status. Radiat. Res., 166(1):55-60(2006)

²“n•q•FA•Ÿ“‡ºŽ¡Ab”ã—Ï–¾@F•úŽËü‚¨‚æ‚ъ‹«‰»Šw•¨Ž¿‚É‚æ‚é”­‚ª‚ñ[–{“–‚É”÷—Ê‚Å‚àŠëŒ¯‚È‚Ì‚©H|Aˆã—ÉȊwŽÐA2005D12A‹¤“¯Ž·•M

Okazaki , R., Ootsuyama, A., Norimura, T.: Radioadaptive Response for Protection against Radiation-Induced Teratogenesis. Radiat. Res.,163(3):266-270(2005)

‘å’ÃŽR²@:@•úŽËü—U”­‚ÆŽv‚í‚ê‚é“Ë‘R•ÏˆÙ‚̃XƒyƒNƒgƒ‹‚ɂ‚¢‚āD•úŽËü¶•¨Œ¤‹†D2005D40.i3jD270|281D

Igari Y, Igari K, Kakihara H, Kato F, Ootsuyama A, Norimura T :Increases radiosensitivity of splenic T lymphocytes in pregnant mice. Int. Cong. Series(ICS) 1276, 2005, 183-4.

Igari K, Igari Y, Kakihara H, Kato F, Ootsuyama A, Norimura T :Role of p53 gene in genetic instability induced by ionizing radiation. Int. Cong. Series(ICS) 1276, 2005, 262-3.

’–Žë˜a”VA‹e’r‰›A‰Á“¡•¶—YA‘å’ÃŽR²A–@‘ºr”VF–^Šé‹Æ‚É‚¨‚¯‚é”í‚΂­ˆã—Ñ̐§‚̍\’zAJ@UOEH@Occup@Environ@HealthD2004.26i1jD138

Okazaki , R., Sakai , A., Ootsuyama, A., Sakata, T., Nakamura, T., Norimura, T.: Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice. Ann. Rheum. Dis., 63(4):453-456(2004)

‰Á“¡•¶—YA‘å’ÃŽR²A–@‘ºr”VFƒ}ƒEƒX‘ÙŽeŽå—vŠíŠ¯Œ`¬Šú‚É‚¨‚¯‚é•úŽËü—U”­“Ë‘R•ÏˆÙ‚̉ðÍAj@UOEH@Occuo@Environ@HealthD2003D25.i1jD139.

Ootsuyama, A., Okazaki , R., Norimura, T.: Effect of exposure to low-dose rate radiation on autoimmune diseases of immunologically suppressed MRL/MpTn-gld/gld mice. J. Radiat. Res., (44):243-247(2003)


‰ªú±—´ŽjA‘å’ÃŽR²A“à“c@ŽuA–@‘ºr”VF‚SD‚VT’èíŽ¥ê‚̍ÊïŒ`«‚È‚ç‚тɍœ“‘ãŽÓ‚ւ̉e‹¿D‚Š@UOEH@Environ@HealthD2002D24i1jD94.

Tanaka, K., Ootsuyama, A., Tanooka, H. & Ansell, J. D.: Test for fused-cell origin of tumors with Mus caroli carrying glucose-6-phosphate dehydrogenase cellular mosaicism. Onc. Rep. 7 : 897-898 (2000)

‰ªú±—´ŽjAŽðˆäº“TA‘å’ÃŽR²Aâ“c•ŽuA’†‘º—˜FF•GŠÖßŒÅ’è‚É‚æ‚鍜“‚̃Aƒ|ƒg[ƒVƒX‚É‚Í‚‚T‚R‚ªŠÖ—^‚·‚éD“ú–{®Œ`ŠO‰ÈŠw‰ïŽGŽD2000D74Di8jDS1683D

‰ªú±—´ŽjA‘å’ÃŽR²A‰Á“¡•¶—YA–@‘ºr”VFŽ©ŒÈ–Ɖu•aƒ}ƒEƒX‚Ì•úŽËüÆŽË‚É‚æ‚鉊ÇŒyŒ¸Œø‰Ê‚ƃAƒ|ƒg[ƒVƒX‚ÌŠÖŒWDJ@UOEH@Occup@Environ@HealthD2000D22i1jD76D

‰Á“¡•¶—YA‘å’ÃŽR²A–쌳˜_A–@‘ºr”V@Fp‚T‚R‚É‚æ‚é•úŽËü—U”­ÃŠï«áŠQ‚Ì–hŒä‹@\D@•úŽËü¶•¨Œ¤‹†D2000D35Di3jD226|236

Tanooka, H., Ootsuyama, A., & Sasaki, H.: Homologaous reconbination between p53 and its pseudogene in a radiation-induced mouse tumor. Cancer Res. 58 : 5649-5651 (1998)

Nomoto, S., Ootsuyama, A., Shioyama, Y., Katsuki, M., Kondo, S. & Norimura, T.: The high susceptibility of heterozygous p53(+/-) mice to malformation after foetal irradiation is related to sub-component apoptosis. Int. J. Radiat. Biol. 74 : 419-429 (1998)

²“n•q•FA“‡“c‹`–çA´…—R‹IŽqA‘å’ÃŽR²@F•úŽËü”­‚ª‚ñ‚ÉŠÖ‚·‚é臒l–â‘è‚ÌŒŸ“¢Ak•úŽËü”­‚ª‚ñ‚ÉŠÖ‚·‚é臒l–â‘茟“¢‰ï•ÒlAŒ´Žq—͈À‘SŒ¤‹†‹¦‰ïA1997D3@‚‚25|57

Mei, N., Kunugita, N., Nomoto, S., Ootsuyama, A. & Norimura, T.: Influence of doner age on the cytotoxicity and mutagenicity of ethylnitrosourea in cultured human T-lymphocytes. J. UOEH 19 : 133-145 (1997)

Ootsuyama, A.: Skin and bone tumors induced by repeated beta-iradiation of mice: Threshold effect and p53 mutations. J. Radiat. Res. 37 : 151-159 (1996)

Ohira, M., Ootsuyama, A., Suzuki, E., Ichikawa , H., Seki, N., Nagase, T., Nomura, N. & Ohki, M.: Identification of a novel human gene containing the tetratricopeptide repeat domain from the down syndrome region of chromosome 21. DNA Res. 3 : 9-16 (1996)


–쌳˜_A‘å’ÃŽR²A–@‘ºr”V@FÃŠï«áŠQ–hŒä‚É‚¨‚¯‚邐53Šà—}§ˆâ“`Žq‚Ì–ðŠ„@p‚T‚RˆË‘¶«ƒAƒ|ƒg[ƒVƒX‚É‚æ‚é‘Ù‰èŠú‚̏áŠQ‹@\‚ɂ‚¢‚āD1996D31i4jD302|310

‘å’ÃŽR²@FƒÀü”½•œÆŽË‚É‚æ‚éƒ}ƒEƒX”畆”­‚ª‚ñG•úŽËü”­‚ª‚ñ‚É‚¨‚¯‚邵‚«‚¢’l—lŒ»Û‚ÌŠm”F‚È‚ç‚Ñ‚É•úŽËü—U”­Žî‚悤‚É‚¨‚¯‚ép‚T‚Rˆâ“`Žq•ÏˆÙ‚̉ðÍD•úŽËü¶•¨Œ¤‹†D1996D31i2jD107|119

‘å’ÃŽR²@FƒÀü”½•œÆŽË‚É‚æ‚éŽîᇔ­¶‚ÉŠÖ‚·‚éü—ʁ[Œø‰ÊŠÖŒWA•úŽËü”­Šà‚É‚µ‚«‚¢’l‚Í‘¶Ý‚·‚é‚©DƒƒfƒBƒJƒ‹EƒgƒsƒbƒNƒXD1995D22D36|37

Tanooka H, Ootsuyama A@F@Non-linear threshold dose response of murine tumorigenesis by repeated beta-irradiation and p53 mutations involved. Radat.Res. Cong. Proc., Vol.2, 1995, 693-6.

Tanooka, H., Ootsuyama, A., Shiroishi, T. & Moriwaki, K.: Distribution of the p53 pseudogene among mouse species and subspecies. Mammalian Genome 6 : 360-362 (1995)

Ootsuyama, A., Nagao, M., Makino, H., Ochiai, A., Yamauchi, Y. & Tanooka, H.: Frequent p53 mutation in mouse tumors induced by repeated beta irradiation. Mol. Carcinogenesis 11 : 236-242 (1994)

Sato FAWatanabe@MAKosako@T,@Ootsuyama@A@F’áü—Ê•úŽËü‚ÆŒ’N‰e‹¿[‹^–â‚É“š‚¦‚ā[Ak”÷—Ê•úŽËü‰e‹¿ŒŸ“¢ê–åˆÏˆõ‰ï•ÒlAŒ´Žq—͈À‘SŒ¤‹†‹¦‰ïA1994D3@‚‚21|30

‘å’ÃŽR²@FƒÀü”½•œÆŽË‚É‚æ‚éŽî‚悤”­¶‚ÉŠÖ‚·‚éü—ʁ[Œø‰ÊŠÖŒW@•úŽËü”­Šà‚É‚µ‚«‚¢’l‚Í‘¶Ý‚·‚é‚©DˆãŠw‚Ì‚ ‚ä‚݁D1994D171i11jD882|883


‘å’ÃŽR²A“cƒm‰ªGA’·”ö”ü“ÞŽqA–q–ì_Ži :ƒqƒgEƒ}ƒEƒXEƒQƒmƒ€‰ðÍŒ¤‹†‚Æ•úŽËü¶•¨Šw IV.•úŽËü”­‚ª‚ñ‚̃Qƒmƒ€•ÏˆÙ 1.•úŽËü”½•œÆŽË‚É‚æ‚Á‚Ä—U”­‚³‚ꂽƒ}ƒEƒXŽî‚悤‚Ìp53ˆâ“`Žq‚̕ω». A NIRS?M (Natl Inst Radiol Sci). 1994. 97. 93-98.

‘å’ÃŽR²A“cƒm‰ªG :•úŽËü”­‚ª‚ñ‚Æ‚»‚̐§Œä ‹@\‰ð–¾‚ւ̃Aƒvƒ[ƒ` IF ŽÀŒ±“I”­‚ª‚ñ 2F ƒx[ƒ^ü”½•œÆŽË‚É‚æ‚éƒ}ƒEƒX”畆”­‚ª‚ñ‚Ì‚µ‚«‚¢’lü—Ê(Radiation carcinogenesis and its control. Approaches to mechanism elucidation. Threshold-like dose response of skin carcinogenesis by repeated beta irradiation in mice). 1993. NIRS?M (Natl Inst Radiol Sci). p94. 14-20.

Ootsuyama, A. & Tanooka, H.: Effect of inhibitor of tumor promotion, a-difluolomethyl-ornithine,on tumor induction by repeated beta irradiation in mice. Jpn. J. Cancer Res. 84 : 34-36 (1993)

Ootsuyama, A. & Tanooka, H.: Zero tumor incidence in mice after repeated lifetime exposures to 0.5 Gy of beta radiation. Radiat. Res. 134 : 244-246 (1993)

Tanooka, H. & Ootsuyama, A.: Threshold-like dose response of mouse skin cancer induction by repeated beta irradiation and its relevance to radiation-induced human skin cancer. Resent Results in Cancer Res. 128 : 231-241 (1993)

Ootsuyama, A., Tanaka, K. & Tanooka, H.: Clonal origin of skin and bone tumors produced by repeated beta-irradiation in mosaic cell mice. Jpn. J. Cancer Res. 83 : 964-967 (1992)

Finch, J., Andrews, K., Slaga, T., Ootsuyama, A., Tanooka, H. et al: Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin. Carcinogenesis 12 : 1519-1522 (1991)

Tanooka, H. & Ootsuyama, A.: Radiation carcinogenesis in mouse skin and its threshold- like response. J. Radiat. Res. Supple 2 32 : 195-201 (1991)

Ootsuyama, A. & Tanooka, H.: Threshold-like dose of local beta irradiation repeated throughout the life span of mice for induction of skin and bone tumors. Radiat. Res. 125 : 98-101 (1991)

Fujiki H, Suganuma M, Suguri H, Ootsuyama A@FNew antitumor promoters: (-)-epigallocatecine gallate and sarcophytols A and B. In Antimutagenesis and anticarcinogenesis mechanisms II, Edited by Yukiaki Kuroda, Delbert M. Shankel, and Michael D. Waters,@Basic life sciences, v. 52@, Plenum Press, c. 1990 pp205-212

‘å’ÃŽR²@F•úŽËü”½•œÆŽË‚É‚æ‚éƒ}ƒEƒX”畆Šà‚Ì—U”­. ˆãŠw‚Ì‚ ‚ä‚Ý. 1990. 153(5). 260.

²“¡ÝA‘å’ÃŽR²A“cƒm‰ªG@F•úŽËüŠ´Žó«‚Ì—\‘ª II t”í–Œ‰ºˆÚAŠ´Žó«ŽŽŒ±(Subrenal capsule assay applied to prediction of tumor radiosensitivity)A Šà‚̗Տ°A1989. 35. p13. 1576-1580.

Ootsuyama, A. & Tanooka, H.: Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation. Cancer Res. 49 : 1562-1564 (1989)

Takagi N, Ootsuyama A, Tanooka H@FCytological evidence for single-cell origin of tumors induced with 3-methylcholanthrene in female mice carrying Cattanach's translocation. . Jpn J Cancer Res. 1986 Apr;77(4):376-84.

Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H@FFormation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986 Nov;7(11):1849-51.

 

Tanaka K, Ootsuyama A, Tanooka H@FClonal origin of spontaneous multiple mammary tumors in mice with cellular mosaicism.

. Gann. 1984 Sep;75(9):792-7.



4. “ú–{•úŽËü‰e‹¿Šw‰ï, “ú–{ŠàŠw‰ï, “ú–{bˆãŠw‰ï, ‚»‚Ì‘¼

£‘Oƒy[ƒW‚É–ß‚é

m•¶ÓF•úŽËü‰q¶ŠwuÀ@ XV“úF2011.12.26n