Assistant Professor:

1. Tsutomu Sugiura (D.V.M.)

2. immune response, metallothionein, heavy metal, B cell, Ca++, platetet

1) Okada, K., Kuroda, E., Yoshida, Y., Yamashita, U., Suzumura, O. and Tsuji, S.: Effects of interferon-b on the cytokine production of astrocytes. J. Neuroimmunol., 159 : 48-54, 2005.

2) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on macrophage function in vivo. J.UOEH, 27: 1-10, 2005.

3) Sugiura, T., Kuroda, E. and Yamashita, U.: Dysfunction of macrophages in metallothionein-knock out mice. J.UOEH, 26: 193-205. 2004.

4) Yamashita, U., Kuroda, E., Yoshida, Y. and Sugiura, T.: Effect of endocrine disrupters on immune responses in vivo. J. UOEH, 25: 365-374, 2003.

5) Sugiura, T. and Yamashita, U.: Strain difference of cadmium-induced cytotoxicity, methallothionein expression and cytokine production in mice. J. UOEH, 25 (Supplement 1) : 197-208, 2003.

6) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on thymocytes in vitro. J.UOEH, 25: 161-170, 2003.

7) Sugiura, T. and Yamashita, U.; Strain difference of cadmium-induced cytotoxicity, methallothionein expression and cytokine production in mice. J.UOEH, 25(S1): 197-208, 2003.

8) Kuroda, E., Sugiura, T., Okada, K., Zeki, K. and Yamashita, U.: Prostaglandin E2 up-regulates macrophage-derived chemokine (MDC) production, but suppresses interferon-inducible protein-10 (IP-10) production by antigen-presenting cells. J. Immunol., 166 : 1650-1658, 2001.

9) Okada, K., Sugiura, T., Kuroda, E., Tsuji, S. and Yamashita, U.: Phenytoin promotes Th2 type immune response in mice. Clin. Exp. Immunol., 124 : 406-413, 2001.

10) Kuroda, E., Sugiura, T., Zeki, K., Yoshida, Y. and Yamashita, U.: Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains : A possible mechanism to polarize Th2 type response in BALB/c mice. J. Immunol., 164 : 2386-2395, 2000.

11) Sugiura, T. and Yamashita, U. : B cell mitogenic activity of metallothionein in vitro. Int. J. Immunopharmacol., 22 : 113-122, 2000.

12) Okada, K., Yoshida, Y., Sugiura, T., Tanaka, H., Tsuji, S., Yamashita, H. and Yamashita, U.: Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice. Life Sciences, 66: 1461-1470, 2000.

13) Shan, B. E., Zeki, K., Sugiura, T. and Yamashita, U.: Chinese medicinal herb, Acanthopanax gracilistylus extract induces cell cycle arrest of human tumor cells in vitro. Jpn. J. Cancer Res., 91: 383-389, 2000.

4. Member of Japanese Society for Immunology and Japanese Biochemical Society

2005/10/3

J.Noguchi (EXT.2334)