研究分野：免疫応答、サイトカイン、自己免疫疾患、アレルギー疾患、腫瘍免疫
研究業績：
1) Noguchi, J., Kuroda, E. and Yamashita, U.: Strain difference of murine bone marrow-derived mast cell functions. J. Leuk. Biol. 78: 605-611, 2005.
2) Okada, K., Kuroda, E., Yoshida, Y., Yamashita, U., Suzumura, O. and Tsuji, S.: Effects of interferon-b on the cytokine production of astrocytes. J. Neuroimmunol., 159 : 48-54, 2005.
3) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on macrophage function in vivo. J.UOEH, 27: 1-10, 2005.
4) Okada, K., Yamashita, U. and Tsuji, S.: Modulation of Na+-dependent glutamate transporter of murine astrocytes by inflammatory mediators. J. UOEH, 27: 150-160, 2005.
5) Sugiura, T., Kuroda, E. and Yamashita, U.: Dysfunction of macrophages in metallothionein-knock out mice. J.UOEH, 26: 193-205. 2004.
6) Yamashita, U., Kuroda, E., Yoshida, Y. and Sugiura, T.: Effect of endocrine disrupters on immune responses in vivo. J. UOEH, 25: 365-374, 2003.
7) Kuroda, E. and Yamashita, U.: Assay system for the effect of prostaglandin E2 in the determination of polarized cytokine production. Methods in Molecular Biology, Vol. 249, Cytokine Protocols, 229-238, 2003.
8) Kuroda, E. and Yamashita, U.: Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role for Th1 activation in Th2-dominan BALB/c mice. J. Immunol., 170 : 757-764, 2003.
9) Sugiura, T. and Yamashita, U.: Strain difference of cadmium-induced cytotoxicity, methallothionein expression and cytokine production in mice. J. UOEH, 25 (Supplement 1) : 197-208, 2003.
10) Kito, T., Kuroda, E. Yokota, A. and Yamashita, U.: Cytotoxicity in glioma cells due to interleukin-12 and interleukin-18-stimulated macrophages mediated by interferon-g-regulated nitric oxide. J. Neurosurg., 98 : 385-399, 2003.
11) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on thymocytes in vitro. J.UOEH, 25: 161-170, 2003.
12) Sugiura, T. and Yamashita, U.; Strain difference of cadmium-induced cytotoxicity, methallothionein expression and cytokine production in mice. J.UOEH, 25(S1): 197-208, 2003.
13) Yamashita, U. and Kuroda, E.: Regulation of macrophage-derived chemokine (MDC; CCL22) production. Critical Rev. Immunol., 22 : 105-114, 2002.
14) Kuroda, E., Kito, T. and Yamashita, U.: Reduced expression of STAT4 and IFN-g in macrophages from BALB/c mice. J. Immunol., 168 : 5477-5482, 2002.
15) Kito, T., Kuroda, E., Yokota, A. and Yamashita, U.: Enhancement of macrophage cytotoxicity against murine gliomas by interferon b: increase in nitric oxide production in responses to glioma-derived soluble factors. J. Neurosurg., 97 : 619-626, 2002.
16) Yamada, H., Kuroda, E., Matsumoto, S., Matsumoto, T., Yamada, T. and Yamashita, U.: Prostaglandin E2 down-regulates viable Bacille de Calmette et Guerin-induced bladder cancer cell, MBT-2 in vitro. Clin. Exp. Immunol., 128 : 52-58, 2002.
17) Kuroda, E., Yoshida, Y., Shan, B.E. and Yamashita, U.: Suppression of macrophage interleukin-12 and tumor necrosis factor-a prodution in mice infected with Toxocara canis. Parasite Immunol., 23 : 305-311, 2001.
18) Kuroda, E., Sugiura, T., Okada, K., Zeki, K. and Yamashita, U.: Prostaglandin E2 up-regulates macrophage-derived chemokine (MDC) production, but suppresses interferon-inducible protein-10 (IP-10) production by antigen-presenting cells. J. Immunol., 166 : 1650-1658, 2001.
19) Yoshida, Y., Myozaki, M., Kuroda E. and Yamashita, U. : Cytotoxic effect of an anti-liver monoclonal autoantibody obtained after neonatal thymectomy in mice. J. Autoimmunity, 16: 373-382, 2001.
20) Kishi, H., Kuroda, E., Mishima, H. K. and Yamashita, U.: Role of TGF-b in the retinoic acid-induced inhibition of proliferation and melanin synthesis in chick retinal pigment epithelial cells in vitro. Cell Biol. Int., 25: 1125-1129, 2001.
21) Okada, K., Sugiura, T., Kuroda, E., Tsuji, S. and Yamashita, U.: Phenytoin promotes Th2 type immune response in mice. Clin. Exp. Immunol., 124 : 406-413, 2001.
22) Okada, K., Tsuji, S. and Yamashita, U.: Cycloxgenase-2 expression in the hippocampus from genetically epilepsy susceptible El mice. Brain Res., 894: 332-335, 2001.
23) Kuroda, E., Sugiura, T., Zeki, K., Yoshida, Y. and Yamashita, U.: Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains : A possible mechanism to polarize Th2 type response in BALB/c mice. J. Immunol., 164 : 2386-2395, 2000.
24) Sugiura, T. and Yamashita, U. : B cell mitogenic activity of metallothionein in vitro. Int. J. Immunopharmacol., 22 : 113-122, 2000.
25) Okada, K., Yoshida, Y., Sugiura, T., Tanaka, H., Tsuji, S., Yamashita, H. and Yamashita, U.: Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice. Life Sciences, 66: 1461-1470, 2000.
26) Yamada, H., Matsumoto, S., Matsumoto, T., Yamada, T. and Yamashita, U.: Murine IL-2 secreting recombinant Bacillus Calmette-Guerin augments macrophage-mediated cytotoxicity against murine bladder cancer MBT-2. J. Urology, 164: 526-531, 2000.
27) Yamada, H., Matsumoto, S., Matsumoto, T., Yamada, T. and Yamashita, U.: Enhancing effect of an inhibitor of nitric oxide synthesis on Bacillus Calmette-Guerin-induced macrophage cytotoxicity against murine bladder cancer cell line MBT-2 in vitro. Jpn. J. Cancer Res., 91: 534-542, 2000.
28) Shan, B. E., Zeki, K., Sugiura, T. and Yamashita, U.: Chinese medicinal herb, Acanthopanax gracilistylus extract induces cell cycle arrest of human tumor cells in vitro. Jpn. J. Cancer Res., 91: 383-389, 2000.
29) Kawakami, Y., Nagai, N., Ohama, K., Zeki, K., Yoshida, Y., Kuroda,
E. and Yamashita, U.: Macrophage-colony stimulating factor inhibits growth
of human ovarian cancer cells in vitro. Eur. J. Cancer, 36 : 1991-1997,
2000.
学会活動：日本免疫学会運営委員、日本寄生虫学会評議員、日本生体防御学会 運営委員、米国免 疫学会会員
文責：医学部免疫学教室（野口順子）
更新日：平成17年10月3日