Research Associate:

1. Yasuhiro Yoshida (Ph. D.)

2. autoimmune disease, immunomodurating activity, cytokine

3.

1) Okada, K., Kuroda, E., Yoshida, Y., Yamashita, U., Suzumura, O. and Tsuji, S.: Effects of interferon-b on the cytokine production of astrocytes. J. Neuroimmunol., 159 : 48-54, 2005.

2) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on macrophage function in vivo. J.UOEH, 27: 1-10, 2005.

3) Yoshida, Y., Koyama, Y., Peng, H., Arman, A., Boch J. A. and Auron, P. E.: IL-1 activates STAT3/NF-kB cross-talk via an unique TRAF6 and p65-dependent mechanism. J. Biol. Chem. 279: 1768-1776, 2004.

4) Ryo, A., Suzuki, F., Yoshida, Y., Perrem, K., Liou, YC. , Wulf, G., Rottapel, R., Yamaoka, S., Lu, KP.: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 12: 1413-26, 2003.

5) Boch, JA. , Yoshida, Y., Koyama, Y., Wara-aswapati, N. , Peng, H. , Unlu, S. , Auron, PE.: Characterization of a cascade of protein interactions initiated at the IL-1 receptor. Biochem Biophys Res Commun. 303: 525-31, 2003.

6) Yamashita, U., Kuroda, E., Yoshida, Y. and Sugiura, T.: Effect of endocrine disrupters on immune responses in vivo. J. UOEH, 25: 365-374, 2003.

7) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on thymocytes in vitro. J.UOEH, 25: 161-170, 2003.

8) Kuroda, E., Yoshida, Y., Shan, B.E. and Yamashita, U.: Suppression of macrophage interleukin-12 and tumor necrosis factor-a prodution in mice infected with Toxocara canis. Parasite Immunol., 23 : 305-311, 2001.

9) Yoshida, Y., Myozaki, M., Kuroda E. and Yamashita, U. : Cytotoxic effect of an anti-liver monoclonal autoantibody obtained after neonatal thymectomy in mice. J. Autoimmunity, 16: 373-382, 2001.

10) Kuroda, E., Sugiura, T., Zeki, K., Yoshida, Y. and Yamashita, U.: Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains : A possible mechanism to polarize Th2 type response in BALB/c mice. J. Immunol., 164 : 2386-2395, 2000.

11) Okada, K., Yoshida, Y., Sugiura, T., Tanaka, H., Tsuji, S., Yamashita, H. and Yamashita, U.: Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice. Life Sciences, 66: 1461-1470, 2000.

12) Kawakami, Y., Nagai, N., Ohama, K., Zeki, K., Yoshida, Y., Kuroda, E. and Yamashita, U.: Macrophage-colony stimulating factor inhibits growth of human ovarian cancer cells in vitro. Eur. J. Cancer, 36 : 1991-1997, 2000.

4. Active Member of Japanese Society for Immunology, Japanese Society for Biochemistry, Japanese Society for Molecular Biology

2005/10/3

J.Noguchi (EXT.2334)