吉田安宏：准教授・医学博士
研究分野：シグナル伝達、自己免疫性疾患、免疫修飾活性、サイトカイン
研究業績：
1) Lin, J.Q., Yoshida, Y. and Yamashita, U.: Suppressive effect of reactive oxygen species on CD40-indnced B cell activation. FEBS Letters, inpress, 2007.
2) Yoshida, Y., Lin, J.Q., Nakano, Y., Ueno, S., Ohmori, S., Fueta, Y., Ishidao, T., Kunugita, N., Yamashita, U. and Hori. H.: 1-BP inhibits NF-?B activity and Bcl-xL expression in astrocytes in vitro and reduces Bcl-xL expression in the brain of rats in vivo. Neurotoxicology, 28:381-386,2007.
3) Kuroda, E., Noguchi, J., Doi, T., Yoshida, Y., Mise-Omata, S. and Yamashita, U.: Strain difference in murine macrophage functions : Prostaglandins as amarher proceedings of the International Symposium on Low-Dose Radiation Exposure and Bio-Defeuse system. P.37-39,2006.
4) Okada, K., Kuroda, E., Yoshida, Y., Yamashita, U., Suzumura, O. and Tsuji, S.: Effects of interferon-b on the cytokine production of astrocytes. J. Neuroimmunol., 159 : 48-54, 2005.
5) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on macrophage function in vivo. J.UOEH, 27: 1-10, 2005.
6) Yoshida, Y., Koyama, Y., Peng, H., Arman, A., Boch J. A. and Auron, P. E.: IL-1 activates STAT3/NF-kB cross-talk via an unique TRAF6 and p65-dependent mechanism. J. Biol. Chem. 279: 1768-1776, 2004.
7) Ryo, A., Suzuki, F., Yoshida, Y., Perrem, K., Liou, YC. , Wulf, G., Rottapel, R., Yamaoka, S., Lu, KP.: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 12: 1413-26, 2003.
8) Boch, JA. , Yoshida, Y., Koyama, Y., Wara-aswapati, N. , Peng, H. , Unlu, S. , Auron, PE.: Characterization of a cascade of protein interactions initiated at the IL-1 receptor. Biochem Biophys Res Commun. 303: 525-31, 2003.
9) Yamashita, U., Kuroda, E., Yoshida, Y. and Sugiura, T.: Effect of endocrine disrupters on immune responses in vivo. J. UOEH, 25: 365-374, 2003.
10) Yamashita, U., Sugiura, T., Yoshida, Y. and Kuroda, E.: Effect of endocrine disrupters on thymocytes in vitro. J.UOEH, 25: 161-170, 2003.
11) Kuroda, E., Yoshida, Y., Shan, B.E. and Yamashita, U.: Suppression of macrophage interleukin-12 and tumor necrosis factor-a prodution in mice infected with Toxocara canis. Parasite Immunol., 23 : 305-311, 2001.
12) Yoshida, Y., Myozaki, M., Kuroda E. and Yamashita, U. : Cytotoxic effect of an anti-liver monoclonal autoantibody obtained after neonatal thymectomy in mice. J. Autoimmunity, 16: 373-382, 2001.
13) Kuroda, E., Sugiura, T., Zeki, K., Yoshida, Y. and Yamashita, U.: Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains : A possible mechanism to polarize Th2 type response in BALB/c mice. J. Immunol., 164 : 2386-2395, 2000.
14) Okada, K., Yoshida, Y., Sugiura, T., Tanaka, H., Tsuji, S., Yamashita, H. and Yamashita, U.: Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice. Life Sciences, 66: 1461-1470, 2000.
15) Kawakami, Y., Nagai, N., Ohama, K., Zeki, K., Yoshida, Y., Kuroda, E. and Yamashita, U.: Macrophage-colony stimulating factor inhibits growth of human ovarian cancer cells in vitro. Eur. J. Cancer, 36 : 1991-1997, 2000.
学会活動： 日本免疫学会会員、日本生化学会会員、日本分子生物学会会員
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文責：医学部免疫学教室（吉田安宏）
更新日：平成21年4月8日