業 績
●上野業績●
１．Cancer関連
1. Iida H, Suzuki M, Goitsuka R, Ueno H.
2. Okada Y, Ueno H, Katagiri M, Oneyama T, Shimomura K, Sakurai S, Mataga I, Moride M, Hasegawa H. Experimental syudy of antiangiogenic gene therapy targeting VEGF in oral cancer. Odontology 98:52-59, 2010.
3. Sako A, Kitayama J, Kojima H, Ueno H, Uchida H, Hamada H, Nagawa H. Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer. Cancer Research. 64: 3624-3628, 2004.
4. Osaki S, Nakanishi Y, Takayama K, Pei X-Y, Ueno H, Hara N. Transfer of IκBα gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. J Exp Clin Cancer Res. 22: 69-75, 2003.
5. Ogawa T, Takayama K, Takakura N, Kitano S, Ueno H. Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble FGF receptor are used with soluble VEGF receptor. Cancer Gene Ther. 9: 633-402, 2002.
6. Yan Y, Zeng Z-Z, Higashi S, Denda A, Konishi Y, Onishi S, Ueno H, Higashi K., Hirai H. Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage. Carcinogenesis. 23: 189-195, 2002.
7. Okamoto M, Ono M, Uchiumi T, Ueno H, Kohno K, Sugimachi K., Kuwano M. Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor β in human cancer cells - transcriptional activation and messenger RNA stabilization. Biochimica, Biophysica Acta. 1574: 24-34, 2002.
8. Oshima Y, Sakamoto T, Hisatomi T, Ishibashi T, Ueno H, Gene transfer of soluble TGF-β receptor II inihibits the progression of experimental PVR. Gene Ther. 9: 1214-1220, 2002
9. Hisatomi T, Sakamoto T, Sassa Y, Kubota T, Ohnishi Y, Ishibashi T, Ueno H, Retinal gliosis was inhibited by systemically expressed soluble TGF-β II receptor in rats. Lab Invest. 82: 863-870, 2002.
10. Takayama K, Ueno H, Nakanishi Y, Sakamoto T, Inoue K, Shimizu K, Oohashi H, Hara N. Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of VEGF receptor into a remote organ. Cancer Res. 60: 2169-2177, 2000.
11. Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima Y, Farber JL, Tanaka M. A possible role for centrosome overduplication in radiation-induced cell death. Oncogene 19: 5281-5290, 2000.
12. Honda M, Sakamoto T, Ishibashi T, Inomata H, Ueno H. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration. Gene Ther 7: 978-985, 2000.
13. Shiose S, Sakamoto T, Yoshikawa H, Hata Y, Kawano Y, Ishibashi T, Inomata
H, Takayama K, Ueno H. Adenovirus-mediated gene transfer of a soluble receptor of vascular endothelial growth factor inhibits the growth of experimental eyelid malignant melanoma. Invest. Ophthalmol. Vis. Sci. 41: 2395-2403, 2000.
14. Tokumitsu K, Nakano S, Ueno H, Niho Y. Suppression of malignant growth potentials of v-Src-transformed human gallbladder epithelial cells by adenovirus-mediated dominant negative H-Ras. J Cell. Physiol. 183: 221-227, 2000.
15. Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGF-β signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 19: 1698-1709, 2000.
16. Ueoka Y, Kato K, Kuriaki Y, Horiuchi S, Terao Y, Nishida J, Ueno H, Wake N. Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-mediated pathway. Br. J. Cancer 82: 891-899, 2000.
17. Saadeh PB, Mehrara BJ, Steinbrech DS, Spector JA, Greewald JA, Chin
GS, Ueno H, Gittes GK, Longaker MT. Mechanisms of FGF-2 modulation of VEGF expression by osteoblastic cells. Endocrinology 141: 2075-2083, 2000.
18. Osaki S, Nakanishi Y, Takayama K, Pei X-H, Ueno H, Hara N. Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells. Cancer Gene Ther. 7: 300-307, 2000.
19. Uruno T, Oki J, Ozawa K, Miyakawa K, Ueno H, Imamura T. Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1. Growth Factors 17: 93-113, 1999.
20. Kotani K, Ogawa W, Hino Y, Kitamura T, Ueno H, Sano W, Sutherland C, Granner DK, Kasuga M. Dominant-negative forms of Akt (protein kinase B) and atypical PKC do not prevent insulin inhibition of PEPCK gene transcription. J. Biol. Chem. 274: 21305-21312, 1999.
21. Saiki M, Mima T, Takahashi JC, Tani S, Yukawa H, Ueno H, Mikawa T, Itoh N, Kikuchi H, Hashimoto N, Miyatake S. Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo. J. Neurooncol. 44: 195-203, 1999.
22. Matsumoto T, Yokote K, Tamura K, Takemoto M, Ueno H, Saito Y, Mori S. Platelet-derived growth factor activates p38 mitogen activated protein kinase through ras- dependent pathway which is important for actin reorganization and cell migration. J. Biol Chem. 274: 13954-13960, 1999.
23. Kusumoto M, Ogawa T, Mizumoto K, Ueno H, Niiyama H, Sato N, Nakamura M, Tanaka M. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells. Clin. Cancer Res. 5: 2140-2147, 1999.
24. Takahashi T, Ueno H, Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18: 2221-2230, 1999.
25. Ohashi M, Kanai F, Ueno H, Tanaka T, Tateishi K, Kawakami T, Koike Y, Ikenoue T, Shiratori Y, Hamada H, Omata M. Adenovirus-mediated p53 tumor suppressor gene therapy of human gastric cancer cells in vitro and in vivo. Gut 44: 366-371, 1999.
26. Takayama K, Ueno H, Pei X, Nakanishi Y, Hara N. The levels of integrin aVb5 may predict the susceptibility to adenovirus-mediated gene transfer in human lung cancer cells. Gene Ther. 5: 361-368, 1998.
27. Sakaue H, Ogawa W, Takata M, Kuroda S, Kotani K, Matsumoto M, Sakaue
M, Nishio S, Ueno H, Kasuga M. Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes. Mol. Endocrinol. 11: 1552-1562, 1997.
28. Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada S, Sakaue M, Ogawa W, Kasuga M. Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. Biochem. J. 322: 873-878, 1997.
２．ＴＧＦ－β, Fibrosis関連
1. Chung I-M, Kim J, Pak YK, Jang Y, Yang W-I, Han I, Park S-J, Park S-W, Huh J, Wight TN, Ueno H. Blockade of TGF-β by catheter-based local intravascular gene delivery dose not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries. International Journal of Cardiology in press, 2010.
2. Ozawa S, Uchiyama K, Nakamori M, Ueda K, Iwahashi M, Ueno H, Muragaki Y, Ooshima A, Yamaue H. Combination gene therapy of HGF and truncated typeⅡTGF-β receptor for rat liver cirrhosis after partial hepatectomy. Surgery 139:563-573, 2006.
3. Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H, Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology. 128:138-146, 2005.
4. Nishioka A, Ogawa Y, Ueno H. In response to Drs. Ubrovskaya and Chukhlovin. Int J Radiat Oncol Biol Phys. 61: 308, 2005.
5. Nagashio Y, Ueno H, Imamura M, Asaumi H, Watanabe S, Yamaguchi T, Taguchi M, Tashiro M, Otsuki M. Inhibition of transforming growth factor β decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. Lab Invest. 84: 1610-1618, 2004.
6. Nishioka, A., Ogawa, Y., Mima, T., Jin, Y-J ., Sonobe, H., Kariya, S., Kubota, K, Yoshida S., Ueno, H. Histopathological amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-β) receptor mediated by adenoviral vector. Int J Radiat Oncol Biol Phys. 58: 1235-1241, 2004.
7. Sakata R, Ueno T, Nakamura T, Ueno H, Sata M. Mechanical stretch induces TGF-beta synthesis in hepatic stellate cells. Eur J Clin Invest. 34:129-36, 2004.
8. Shirakata , Ueno H, Hanakawa Y, Kameda K, Yamasaki K, Tokumaru S, Yahata Y, Tohyama M, Sayama K, Hashimoto K. TGF-beta is not involved in early phase growth inhibition of keratinocytes by 1alpha,25(OH)(2)vitamin D(3). J Dermatol Sci. 36:41-50, 2004.
9. Nie L, Imamura M, Itoh H, Ueno H, Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin Ⅱ receptor blocker, on CCl4-induced liver fibrosis in rats. J UOEH. 26:165-177, 2004.
10. Zhou A, Ueno H, Shimomura M, Tanaka R, Shirakawa T, Nakamura H, Matsuo M, Iijima K. Blockade of TGF-β action ameliorates renal dysfunction and histological progress in Anti-GBM nephritis. Kidney Int. 64: 92-101, 2003.
11. Cui X, Shimizu I, Lu G, Itonaga M, Inoue H, Shono M, Tamaki K, Fukuno H, Ueno H, Ito S. Inhibitory effect of a soluble transforming growth factor beta type II receptor on the activation of rat hepatic stellate cells in primary culture. J Hepatol. 39:731-7, 2003.
12. Mehrara BJ, Spector JA, Greenwald JA, Ueno H, Longaker MT. Adenovirus-mediated transmission of a dominant negative transforming growth factor-beta receptor inhibits in vitro mouse cranial suture fusion. Plast Reconstr Surg. 110: 506-514, 2002.
13. Nakamura T, Sakata R, Ueno T, Sata M, Ueno H. Inhibition of Transforming Growth Factor-β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 32: 247-255, 2000.
14. SakamotoT, Ueno H, Sonoda K, Hｉsatomi T, Shimizu K, Ohashi H, Inomata H. Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis. Gene Ther. 7: 1915-1924, 2000.
15. Ueno H, Sakamoto T, Nakamura T, Astuchi N, Takeshita A, Shimizu S, Ohashi H. A soluble TGF-β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum Gene Ther. 11: 33-42, 2000.
16. Glick A, Popescu N, Alexander V, Ueno H, Bottinger E, Yuspa SH. Defects in TGF-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes. Proc. Natl. Acad. Sci. USA 96: 14949-14954, 1999.
17. Saadeh PB, Mehrara BJ, Steinbreach DS, Dudziak ME, Greenwald JA, Luchs JS, Spector JA, Ueno H, Gittes GK, Longaker MT. Transforming growth factor beta 1 modulates the expression of VEGF by osteoblasts. Am. J. Physiol. 277: C628-C637, 1999.
18. Yamamoto H, Atsuchi N, Tanaka H, Ogawa W, Abe M, Takeshita A, Ueno H. Separate roles for H-Ras and Rac in signaling by transforming growth factor (TGF)-beta. H-Ras is essential for activation of MAP kinase, partially required for transcriptional activation by TGF-beta, but not required for signaling of growth suppression by TGF-beta. Eur. J. Biochem. 264: 110-119, 1999.
19. Qi Z, Astuchi N, Ooshima A, Takeshita A, Ueno H. Blockade of TGF-β signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. USA 96:2345-2349, 1999.
20. Li Q, Muragaki Y, Hatamura I, Ueno H, Ooshima A. Stretch-induced collagen synthesis in cultured smooth muscle cells from rabbit aortic media and a possible involvement of angiotensin II and transforming growth factor-β. J. Vas. Res. 35: 93-103, 1998.
21. Yamamoto H, Ueno H, Ooshima A, Takeshita A. Adenovirus-mediated transfer of a truncated TGF-β type II receptor completely and specifically abolishes diverse signaling by TGF-β in vascular wall cells in primary culture. J. Biol. Chem. 271: 16253-16259, 1996.
３．Vasuclar Biology関連
1. Okabe T, Hoshiga M, Negoro N, Nakakoji T, Arishiro K, Ishihara T, Ueno H, Hanafusa T. Rabbit plaque models closely resembling lesions in human coronary artery disease. International Journal of Cardiology 147: 271-277, 2011.
2. Ichikura H, Eto M, Ueno H, Harada M, Takayama K, Tokuda N, Tatsugami K, Naito S. In vivo growth of transitional and renal cell carcinoma cell lines can be suppressed by the adenovirus-mediated expression of a soluble form of vascular endothelial growth factor receptor. Oncology Reports 15:1333-1337, 2006.
3. Arakawa H, Qian J-Y, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H. Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxideized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits. Circulation 111:3302-3309, 2005.
4. Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Hori M. The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. J Biol Chem. 278:20770-20777, 2003.
5. Takeya H, Gabazza EC, Aoki S, Ueno H, Suzuki K. Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. Blood. 102: 1693-1700, 2003.
6. Davies EL, Ramsden JD, Cocks H, Searle PF, Watkinson JC, Ueno H, Logan A, Franklyn JA, Mautner V, Eggo MC. Adenovirus-mediated expression of dominant negative fibroblast growth factor (FGF) receptor 1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice. J Clin Endocrinol Metab. 88:4472-4480, 2003.
7. Qian J-Y, Haruno A, Asada Y, Nishida N, Saito Y, Matsuda T, Ueno H. Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries. Circ. Res. 91: 1063-1069, 2002.
8. Hirotani S, Otsu K, Nishida K, Higuchi Y, Morita T, Nakayama H, Yamaguchi O, Mano T, Matsumura Y, Ueno H, Tada M, Hori M. Involvement of NF-κB and ASK1 in G-Protein coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 105: 509-15, 2002.
9. Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsumura Y, Ueno H, Tada M, Hori M. Involvement of reactive oxygen species-mediated NF-κB activation in TNF-α-induced cardiomyocyte hypertrophy. J Mol. Cell, Cardiol. 34: 233-40, 2002.
10. Sakaue H, Konishi M, Ogawa W, Asaki T, Mori T, Yamasaki M, Takata M, Ueno H, Kato S., Kasuga M, Itoh N. Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev. 16: 908-912, 2002.
11. Chung I-M, Ueno H, Pak Kim, Kim J-W, Choi D-H, Shin J G, Yang W-I, Jang SY. Catheter-based adenovirus-mediated local intravascular gene delivery of a soluble TGF-βtype II receptor using an Infiltrator in porcine coronary arteries: efficacy and complications. Exp Mol Med. 34: 299-307, 2002.
12. Ikeda Y, Yonemitsu Y, Sakamoto T, Ishibashi T, Ueno H, Kato A, Nagai Y, Fukumura M, Inomata H, Hasegawa M, Sueishi K. Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue: efficient gene transfer by brief exposure. Exp Eye Res. 75:39-48, 2002.
13. Greenwald JA, Mehrara BJ, Spector JA, Warren SM, Fagenholz PJ, Smith LE, Bouletreau PJ, Crisera FE, Ueno H, Longaker MT. In vivo modulation of FGF biological activity alters cranial suture fate. Am J Pathol. 158(2): 441-452, 2001.
14. Atsuchi N, Nishida T, Marutsuka K, Asada Y, Kamikubo Y, Takeshita A, Ueno H. Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries. Circulation. 103: 570-575, 2001.
15. Nakayama Y, Ji-Youn K, Nishi S, Ueno H, Matsuda T. Development of high-performance stent: gelatinous photogel-coated stent that permits drug delivery and gene transfer. J. Biomed. Mater. Res. 57: 559-566, 2001.
16. Masaki I, Yonemitsu Y, Komori K, Ueno H, Nakashima Y, Nakagawa K, Fukumura M, Kato A, Hasan MK, Nagai Y, Sugimachi K, Hasegawa M, Sueishi K. Recombinant sendai virus-mediated gene transfer to vasculature: a new class of efficient gene transfer vector to the vascular system. FASEB J. 15: 1294-1296, 2001.
17. Yashima R, Abe M, Tanaka K, Ueno H, Shitara K, Takenoshita, S, SatoY. Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells. J. Cell. Physiol. 188: 201-210, 2001.
18. Iida N, Namikawa K, Kiyama H, Ueno H, Nakamura S, Hattori S. Requirement of ras for the activation of mitogen-acitivated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons. J. Neurosci. 21: 6459-6466, 2001.
19. Iwatate M, Miura T, Ikeda Y, Kawamura S, Dairaku Y, Okamura T, Kimura M, Yamaguchi K, Ueno H, Matsuzaki M. Effects of in vivo gene transfer of FGF-2 on cardiac function and collateral vessel formation in microembolized rabbit heart. Jpn. Circ. J. 65: 226-231, 2001.
20. Tanaka E, Hattan N, Ando K, Ueno H, Sugio Y, Mohammed MU, Voltchikhina SA, Mori H. Amelioration of microvascular myocardial ischemia by gene transfer of vascular , .endothelial growth factor in rabbits. J Thorac Cardiov Sur 120: 720-728, 2000.
21. Hirashima Y, Ueno H, Karasawa K, Yokoyama K, Setaka M, Takaku A. Transfection of the plasma-type platelet-activating factor acethylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons. Brain Res. 885: 128-132, 2000.
22. Iwasaki H, Eguchi S, Ueno H, Marumo F, Hirata Y. Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor. Am. J. Physiol.278: H521-H529, 2000.
23. Morishige K, Shimokawa H, Yamawaki T, Miyata K, Eto Y, Kandabashi T, Yogo K, higo T, Egashira K, Ueno H, Takeshita A. Local adnovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo. J. Am. Coll. Cardiol. 35: 1040-1047, 2000.
24. Eguchi S, Iwasaki H, Ueno H, Frank GD, Motley ED, Eguchi K, Marumo F, Hirata Y, Inagami T. Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J. Biol. Chem. 274: 36843-36851, 1999.
25. Iwasaki H, Eguchi S, Ueno H, Marumo F, Hirata Y. Endothelin-mediated vascular growth requires p42/p44 MAP kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor. Endocrinology 140: 4659-4668, 1999.
26. Nishida T, Ueno H, Astuchi N, Kawano R, Asada Y, Nakahara Y, Kamikubo Y, Takeshita A, Yasui H. Adenovirus-mediated local expression of human tissue factor pathway inhibitor eliminates shear stress-induced recurrent thrombosis in the injured carotid artery of the rabbit. Circ Res. 84: 1446-1452, 1999.
27. Yukawa H, Miyatake S, Saiki M, Takahashi JC, Mima T, Ueno H, Nagata I, Kikuchi H, Hashimoto N. In vitro growth suppression of vascular smooth muscle cells using adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor. Atherosclerosis 141: 125-132, 1998.
28. Sakamoto T, Ueno H, Goto Y, Oshima Y, Ishibashi T, Inomata H. A virectomy improves the transfection efficiency of adenoviral vector-mediated gene transfer to Muller cells. Gene Ther. 5: 1088-1097, 1998.
29. Maru Y, Yamaguchi S, Takahashi T, Ueno H, Shibuya M. Virally activated Ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines. J. Cell. Physiol. 176: 223-234, 1998.
30. Sakamoto T, Ueno H, Goto Y, Oshima Y, Yamanaka I, Ishibashi T, Inomata H. Retinal functional change caused by adenoviral vector-mediated transfection of LacZ gene. Hum. Gene Ther. 9: 789-799, 1998.
31. Li Q, Muragaki Y,Ueno H, Ooshima A. Stretch-induced proliferation of cultured vascular smooth muscle cells and a possible involvement of local renin-angiotensin system and platelet-derived grwoth factor. Hypertens. Res. 20: 217-223, 1997.
32. Ueno H, Li J.-J, Masuda S, Qi Z, Yamamto H, Takeshita A. Adenovirus-mediated expression of secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo. Arterioscl. Thromb. Vasc. Biol. 17: 2453-2460, 1997.
33. Ueno H, Haruno A, Morisaki N, Furuya M, Kangawa K, Takeshita A, Saito Y. Local expression of C-type natriuretic peptide markedly suppresses neointimal formation in rat injured arteries through an autocrine/paracrine loop. Circulation 96: 2272-2279, 1997.
34. Ueno H, Yamamoto H, Ito S, Li J.-J, Takeshita A. Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. Arterioscl. Thromb. Vasc. Biol. 17: 898-904, 1997.
35. Takahashi T, Kawahara Y, Okuda M, Ueno H, Takashita A, Yokoyama M. Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J. Biol. Chem. 272: 16018-16022, 1997.
36. Ueno H, Masuda S, Li J.-J, Nishio S, Li J-J, Yamamoto H, Takeshita A. Adenovirus-mediated transfer of cyclin-dependent kinase inhibitor-p21 suppresses neointimal formation in the balloon-injured rat carotid arteries in vivo. Ann. NY. Acad. Sci.811: 401-411, 1997.
37. Ueno H. Adenovirus-mediated gene transfer into injured arteries: Quantitative analysis of repeated administration. Gerontology 42: 25-36, 1996.
38. Ueno H, Li J.-J,Tomita H, Yamamoto H, Pan Y, Kanegae Y, Saito I, Takeshita A. Quantitative analysis of repeated adenovirus-mediated gene transfer into injured canine femoral arteries. Arterioscler. Thromb. Vasc. Biol. 15: 2246-2253, 1995.
39. Li J-J, Ueno H, Pan Y, Tomita H, Yamamoto H, Kanegae Y, Saito I, Takeshita A. Percutaneous transluminal gene transfer into canine myocardium in vivo by replication-defective adenovirus. Cardiovasc. Res. 30: 97-105, 1995.
40. Li J.-J, Ueno H, Yamamoto H, Kanegae Y, Saito I, Takeshita A. Adenovirus-mediated arterial gene transfer does not require prior injury for submaximal gene expression. Gene Ther. 2: 351-354, 1995.
41. Mima T, Ueno H, Fischman DA, Williams LT, Mikawa T. FGF-receptor is required for in vivo cardiac myocyte proliferation at early embryonic stage of heart development. Proc. Natl. Acad. Sci. USA. 92; 467-471, 1995.
42. Hata Y, Nakagawa K, Ishibashi T, Inomata H, Ueno H, Sueishi K. Hypoxia-induced expression of vascular endothelial growth factor by retinal glial cells promotes in vitro angiogenesis. Virc. Arch. 426: 479-486, 1995.
43. Ueno H, Escobedo JA, Williams LT. Dominant-negative mutations of PDGF receptors: Inhibition of receptor function by ligand-dependent formation of heterodimers between PDGF α- and β-receptors. J. Biol. Chem. 268: 22814-22819, 1993.
44. Ueno H, Gunn M, Dell K, Tseng Jr. A, Williams L. A truncated form of FGF receptor 1 inhibits signal transduction by multiple types of FGF receptors. J. Biol. Chem. 267:1470-1476, 1992.
45. de Vries C, Escobedo JA, Ueno H, Ferrara M, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991,1992.
46. Ueno H, Colbert H, Escobedo JA, Williams LT. Inhibition of PDGF β-receptor signal transduction by coexpression of a truncated receptor. Science 252: 844-848, 1991.
47. Ueno H,Perryman B, Roberts R, Schneider MD. Differentiation of cardiac myocytes after mitogen withdrawal exhibits three sequential states of the ventricular growth response. J. Cell Biol. 107: 1911-1918, 1988.
48. Ueno H, Sumimoto K, Hashimoto T, Hirata M, Kuriyama H. Effects of procaine on pharmaco-mechanical coupling mechanisms activated by acetylcholine in smooth muscle cells of porcine coronary artery. Circ. Res. 60: 356-366, 1987.
49. Kitamura K, Itoh T, Ueno H, Kanmura Y, Inoue R, Kuriyama H. The stabilization of vascular smooth muscle by procaine. Drug. Exp. Clin. Res. 12: 773-784, 1986.
50. Schneider MD, Payne PA, Ueno H, Perryman MB, Roberts R. Dissociated expression of c-myc and a fos-related competence gene during cardiac myogenesis. Mol. Cell. Biol. 6: 4140-4143, 1986.
51. Itoh T, Ueno H, Kuriyama H. Calcium-induced calcium release mechanism in vascular smooth muscles-assessments based on contractions evoked in intact and sponin-treated skinned muscles. Experientia 41: 989-996, 1985.
52. Ueno H, Calcium mobilization in enzymically isolated single intact and skinned muscle cells of the porcine coronary artery. J. Physiol. (Lond) 262: 103-117, 1985.
53. Itoh T, Ueno H, Kanmura Y, Suematsu E, Kuriyama H. Regulations of cytoplasmic Ca concentrations in vascular smooth muscles. INSERM J. 124: 225-232, 1984.
54. Itoh T, Kuriyama H, Ueno H, Mechanisms of the nitoroglyseine-induced vasodilation in vascular smooth muscles of the rabbit and pig. J. Physiol. (Lond) 343: 233-252, 1983.
55. Kuriyama H, Itoh T, Suematsu E, Ueno H, Kanmura Y, Sasaguri T. Mehanisms of nitoroglyserine-induced vasodilation-Assessments from actions of cyclic GMP. Jikeikai Med. J. 30: 105-116, 1983.
●真崎業績●
1. Mazaki Y, Nishimura Y, Sabe H. GBF1 bears a novel phosphatidylinositol-phosphate
binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved
in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol
Cell 23: 2457-2467, 2012.
2. Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S,
Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H. GEP100 links
epidermal growth factor receptor signaling to Arf6 activation to induce
breast cancer invasion. Nat Cell Biol 10: 85-92, 2008.
3. Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H. Fbx8 makes Arf6 refractory to function
via ubiquitination. Mol Biol Cell 19: 822-832, 2008.
4. Nam J-M, Onodera Y, Mazaki Y, Miyoshi H, Hashimoto S, Sabe H. CIN85, a Cb1-interacting protein, is
a component of AMAP1-mediated breast cancer invasion machinery. EMBO J
26: 647-656, 2007.
5. 真崎雄一
好中球の指向性センシングと活性酵素産生
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[文責：（生化学講座）更新日：7/31/2013]