Toyohi Isse, M.D, Ph.D.
Toyohi ISSE, M.D., Ph.D.
Associate Professor, Career Guidance Department
Iseigaoka 1-1, Yahatansihi
Kitakyushu, Fukuoka 807-8555
Member, University of Occupational and Environmental Health
Training and Education:
Ph.D., Department of Physiology, University
of Occupational and Environmental
Health, School of Medicine.
1. Genetic factors involved in the
alcohol drinking preference and toxicity. Individual differences in alcohol
preference are clearly genetically determined, which may translate into a
genetic predisposition for alcohol abuse and alcoholism. Specific genes
responsible for the increased or decreased susceptibility to alcohol abuse
remain largely unknown. Our laboratory studies the role of aldehyde
dehydrogenase 2 (ALDH2), as genetic factors associated with
alcoholism--including toxicity, carcinogenesis, abuse, and drinking
preference. Experimental approaches include transgenic mouse lines.
2. Gene expression approach of finding new biomarkers.
Using micro array and quantitative RT-PCR techniques.
3. Chemical-protein adducts and chemical metabolite
Hygiene, Occupational Health
Toxicology, Biomarker, Molecular Biology