Professor
  1. Hiroshi Kasai(Ph.D.)
  2. Key words
    Oxygen radicals / 8-hydroxyguanine / 2-hydroxyadenine / Carcinogenesis
  3. Recent Selected Publications

    Kamiya,H., Ueda,T., Ohgi,T., Matsukage,A., Kasai,H. Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res., 23, 761-766 (1995)

    Nagashima,M., Kasai,H., Yokota,J., Nagamachi,Y., Ichinose,T., Sagai,M. Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process. Carcinogenesis, 16, 1441-1445 (1995)

    Nagashima,M., Tsuda,H., Takenoshita,S., Nagamachi,Y., Hirohashi,S., Yokota,J., Kasai,H. 8-Hydroxydeoxyguanosine levels in DNA of human breast cancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer Letters, 90, 157-162 (1995)

    Hirano, T., Homma, Y., Kasai, H. Formation of 8-hydroxyguanine in DNA by aging and oxidative stress. In "Oxidative Stress and Aging", Bilkhauser Verlag/Basel, pp69-76(1995)

    Kamiya,H., Kasai,H. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. J. Biol. Chem., 270, 19446-19450 (1995)

    Hirano, T., Yamaguchi, Y., Hirano, H., and Kasai, H. Age-associated change of 8-hydroxyguanine repair activity in cultured human fibroblasts. Biochem. Biophys. Res. Commun., 214, 1157-1162 (1995)

    Murata-Kamiya, N., Kamiya, H., Iwamoto, N., and Kasai, H. Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals. Carcinogenesis, 16, 2251-2253 (1995)

    Asami, S., Hirano, T., Yamaguchi, R., Tomioka, Y., Itoh, H., and Kasai, H. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. Cancer Res., 56, 2546-2549 (1996)

  4. Membership in academic society
    Japanese Cancer Association,The Chemical Society of Japan, The Japanese Biochemical Society, The Japanese Society of Physical Fitness and Sports Medicine, Environmental Mutagen Society of Japan, The Japan Radiation Research Society, Japan Society for Occupational Health, UOEH Asociation of Health Sciences
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