1. 葛西　宏（理学博士）

  2. 研究内容のキーワード
    　　酸素ラジカル、８ーヒドロキシグアニン、
    　　２ーヒドロキシアデニン、発がん

  3. 研究業績
    Kamiya,H., Ueda,T., Ohgi,T., Matsukage,A., Kasai,H. Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res., 23, 761-766 (1995)

    Nagashima,M., Kasai,H., Yokota,J., Nagamachi,Y., Ichinose,T., Sagai,M. Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process. Carcinogenesis, 16, 1441-1445 (1995)

    Nagashima,M., Tsuda,H., Takenoshita,S., Nagamachi,Y., Hirohashi,S., Yokota,J., Kasai,H. 8-Hydroxydeoxyguanosine levels in DNA of human breast cancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer Letters, 90, 157-162 (1995)

    Hirano,T., Homma,Y., Kasai,H. Formation of 8-hydroxyguanine in DNA by aging and oxidative stress. In "Oxidative Stress and Aging", Bilkhauser Verlag/Barsel, pp69-76 (1995)

    Kamiya,H., Kasai,H. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. J. Biol. Chem., 270, 19446-19450 (1995)

    Hirano, T., Yamaguchi, Y., Hirano, H., and Kasai, H. Age-associated change of 8-hydroxyguanine repair activity in cultured human fibroblasts., Biochem. Biophys. Res. Commun, 214, 1157-1162 (1995)

    Murata-Kamiya, N., Kamiya, H., Iwamoto, N., and Kasai, H. Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals., Carcinogenesis, 16, 2251-2253 (1995)

    Asami, S., Hirano, T., Yamaguchi, R., Tomioka, Y., Itoh, H., and Kasai, H. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking, Cancer Res., 56,2546-2549(1996)

    浅海信也、葛西　宏：
    運動と酸化的DNA損傷、８ーヒドロキシグアニン、最新医学、51,320-325(1996)

  4. 学会活動、社会活動 日本癌学会、日本化学会、日本生化学会、日本体力医学会、日本環境変異原学会、日本放射線影響学会、日本産業衛生学会、産業医科大学学会
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