Research Associate
  1. Hiroyuki Kamiya (Ph.D.)

  2. Key words
    DNA damage / 2-hydroxyadenine / 8-hydroxyguanine / mutagenesis / carcinogenesis

  3. Recent Selected Publications

    Kamiya, H., Kasai, H. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. J. Biol. Chem.,270, 19446-19450 (1995)

    Kamiya, H., Ueda, T., Ohgi, T., Matsukage, A., Kasai, H. Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res., 23, 761-766 (1995)

    Murata-Kamiya, N., Kamiya, H., Iwamoto, N., and Kasai, H. Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals. Carcinogenesis, 16, 2251-2253 (1995)

    Kamiya, H., Murata-Kamiya, N., Koizume, S., Inoue, H., Nishimura, S., Ohtsuka, E. 8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Effects of sequence contexts on mutation spectra. Carcinogenesis, 16, 883-889 (1995)

    Kamiya, H., Miura, H., Murata-Kamiya, N., Ishikawa, H., Sakaguchi, T., Inoue, H., Sasaki, T., Masutani, C., Hanaoka, F., Nishimura, S., Ohtsuka, E. 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH3T3 cells. Nucleic Acids Res., 23, 2893-2899 (1995)

    Koizume, S., Kamiya, H., Inoue, H., Ohtsuka, E. Synthesis and thermodynamic stabilities of damaged DNA involving 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in a ras gene fragment. Nucleosides and Nucleotides, 13, 1517-1534 (1994)

    Kamiya, H., Murata, N., Murata, T., Iwai, S., Matsukage, A., Masutani, C., Hanaoka, F., Ohtsuka, E. Cyclobutane thymine-photodimers in a ras protooncogene hot spot activate the gene by point mutation. Nucleic Acids Res. 21, 2355-2361 (1993)

    Kamiya, H., Miura, H., Kato, H., Nishimura, S., Ohtsuka, E. Induction of mutation of a synthetic c-Ha-ras gene containing hypoxanthine. Cancer Res., 52 , 1836-1839 (1992)

    Kamiya, H., Miura, K., Ishikawa, H., Inoue, H., Nishimura, S., Ohtsuka, E. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res., 52, 3483-3485 (1992)

    Kamiya, H., Suzuki, M., Komatsu, Y., Miura, H., Kikuchi, K., Sakaguchi, T., Murata, N., Masutani, C., Hanaoka, F., Ohtsuka, E. An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions. Nucleic Acids Res., 20, 4409-4415 (1992)

  4. Membership in academic society
    Japanese Cancer Association, The Molecular Biology Society of Japan, The Japanese Biochemical Society, Environmental Mutagen Society of Japan, The Pharmaceutical Society of Japan, UOEH Asociation of Health Sciences
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