1. 紙谷 浩之(薬学博士)

  2. 研究内容のキーワード
      DNA損傷、2−ヒドロキシアデニン、
      8−ヒドロキシグアニン、変異、発癌

  3. 研究業績
    Kamiya, H., Kasai, H. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. J. Biol. Chem., 270, 19446-19450 (1995)

    Kamiya, H., Ueda, T., Ohgi, T., Matsukage, A., Kasai, H. Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res., 23, 761-766 (1995)

    Murata-Kamiya, N., Kamiya, H., Iwamoto, N., and Kasai, H. Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals., Carcinogenesis, 16, 2251-2253 (1995)

    紙谷 浩之、葛西 宏:
    活性酸素による8ーヒドロキシグアニンの生成と生体との関わり:突然変異・発がん・修復、衛生化学, 41, 307-319 (1995)

    紙谷 浩之、葛西 宏:
    活性酸素によって生ずるDNA損傷と誘発される変異、蛋白質 核酸 酵素, 40, 1571-1577 (1995)

    Kamiya, H., Murata-Kamiya, N., Koizume, S., Inoue, H., Nishimura, S., Ohtsuka, E. 8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Effects of sequence contexts on mutation spectra. Carcinogenesis, 16, 883-889 (1995)

    Kamiya, H., Miura, H., Murata-Kamiya, N., Ishikawa, H., Sakaguchi, T., Inoue, H., Sasaki, T., Masutani, C., Hanaoka, F., Nishimura, S., Ohtsuka, E. 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH3T3 cells. Nucleic Acids Res., 23, 2893-2899 (1995)

    Koizume, S., Kamiya, H., Inoue, H., Ohtsuka, E. Synthesis and thermodynamic stabilities of damaged DNA involving 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in a ras gene fragment. Nucleosides and Nucleotides 13, 1517-1534 (1994)

    Kamiya, H., Murata, N., Murata, T., Iwai, S., Matsukage, A., Masutani, C., Hanaoka, F., Ohtsuka, E. Cyclobutane thymine-photodimers in a ras protooncogene hot spot activate the gene by point mutation. Nucleic Acids Res. 21, 2355-2361 (1993)

    Kamiya, H., Miura, K., Ishikawa, H., Inoue, H., Nishimura, S., Ohtsuka, E. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res., 52, 3483-3485 (1992)

  4. 学会活動、社会活動 日本癌学会、日本分子生物学会、日本生化学会、日本環境変異原学会、日本薬学会、産業医科大学学会
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