[Department of Pharmacology 1/10/2008]

1.  Mechanism on the regulation of noradrenaline transporter function

2.  Study on the catecholamine secretion in bovine adorenal chromaffin cells

3.  Study on the effect of the environmental estrogenic pollutants and phytoestrogen on neural fanction

[Keywords]
Noradrenaline transporter
Catecholamine
Exocytosis
Environmental estrogenic pollutants
Phytoestrogen
Chromaffin cell

1.          Liu M, Yanagihara N, Toyohira Y, Tsutsui M, Ueno S, Shinohara Y. (2007) Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Endocrinorogy

2.          Shinohara Y, Toyohira Y, Ueno S, Liu M, Tsutsui M, Yanagihara N. (2007) Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Biochemical. Pharmacol.

3.          Shinkai K, Toyohira Y, Yoshimura R, Tsutsui M, Ueno S, Nakamura J, Yanagihara N. (2007) Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran. Naunyn-Schmiedeberg’s Archives of Pharmacology 375:65-72

4.          Takahashi K, Toyohira Y, Ueno S, Tsutsui M, Yanagihara N. (2006) Capsaicin inhibits catecholamine secretion and synthesis by blocking Na⁺ and Ca²⁺ influx through a vaniloid receptor-independent pathway in bovine adrenal medullary cells. Naunyn-Schmiedeberg’s Archives of Pharmacology 374:107-116

5.          Uezono Y, Toyohira Y, Yanagihara N, Wada A, Taniyama K. (2006) Inhibition by selenium compounds of catecholamine secretion due to inhibition of Ca²⁺ influx in cultured bovine adrenal chromaffin cells. J Pharmacol Sci 101: 223-229,

6.          Yanagihara N, Lui M, Toyohira Y, Tsutsui M, Ueno S, Shinohara Y, Takahashi K, Tanaka K. (2006) Stimulation of catecholamine synthesis through unique estrogen receptors in bovine adrenomedullary plasma membrane by 17?-estradiol. Biochem. Biophys. Res. Commun. 339:548-553

7.          Toyohira Y, Kubo T, Watanabe M, Uezono Y, Ueno S, Shinkai K, Tsutsui M, Izumi F, Yanagihara N. (2005) Selective blockade of nicotinic acetylcholine receptors by pimobendan, adrug for the treatment of heartfailure: reduction of catecholamine secretion and synthesis in adrenal medullary cells. Naunyn-Schmiedeberg’s Archives of Pharmacology 371:107-113

8.          Shinkai K, Yoshimura R, Toyohira Y, Ueno S, Tsutsui M, Nakamura J, Yanagihara N. (2005) Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells. Biochemical. Pharmacol. 70:1389-1397

9.          Yoshimura R, Shinkai K, Toyohira Y, Ueno S, Yanagihara N, Nakamura J. (2005) Effect of zotepine and olanzapine on noradrenaline transporter in cultured bovine adrenal medullary cells. Hum. Psychopharmacol. Clin. Exp. 20:1-8

10.      Yanagihara N, Toyohira Y, Ueno S, Tsutsui M, Utsunomiya K, Lui M, Tanaka K. (2005) Stimulation of catecholamine synthesis by environmental estrogenic pollutants.　Endocrinorogy 146:265-272

11.      Toyohira Y, Utsunomiya K, Ueno S, Minami K, Uezono Y, Yoshimura R, Tsutsui M, Izumi F, (2003) Yanagihara N. Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A. Biochemical. Pharmacol. 65: 2049-2054

12.      Kawada Y, Ueno S, Asayama K, Tsutsui M, Utsunomiya K, Toyohira Y, Morisada N, Tanaka K, Shirahata A, Yanagihara N. (2003) Stimulation of catecholamine synthesis by orexin-a in bovine adrenal medullary cells through orexin receptor 1. Biochemical. Pharmacol. 66:141-147

13.      Hara K, Minami K, Ueno S, Toyohira Y, Tsutsui M, Shigematsu A, Yanagihara N. (2002) Up-regulation of noradrenaline transporter in response to prolonged exposure to ketamine. Naunyn-Schmiedeberb’s Arch. Pharmacol. 365:406-412

14.      Yoshimura R, Yanagihara N, Hara K, Nakamura J, Toyohira Y, Ueno S, Izumi F. (2001) Dual phases of functional change in norepinephrine transporter in cultured bovine adrenal medullary cells by long-term treatment with clozapine. J. Neurochem. 77:1018-1026

15.      Utsunomiya K, Yanagihara N, Tachikawa E, Cheah T B, Kajiwara K, Toyohira Y, Ueno S, Izumi F. (2001) Stimulation of catecholamine synthesis in cultured bovine adrenal medullary cells by leptin. J. Neurochem. 76:1652-1661

16.      Shiraishi S, Shibuya I, Uezono Y, Yokoo H, Toyohira Y, Yamamoto R, Yanagita T, Kobayashi H, Wada A. (2001) Heterogeneous increases of cytoplasmic calcium : Distinct effects on dowm-regulation of cell surface sodium channels and sodium channel subunit mRNA leveles. British J. pharmacol. 132:1455-1466

17.      Uryu K, Minmi K, Yanagihara N, Hara K, Toyohira Y, Izumi F, Shigematsu A. (2000) Inhibition by neuromuscular blocking drugs of norepinephrine transporter in cultured bovine adrenal medullary cells.. Anesth. Analg. 91: 1141-1145

18.      Shibuya I, Tanaka K, Uezono Y, Ueta Y, Toyohira Y, Yanagihara N, Izumi F, Yamashita H. (1999) Prostaglandin E₂ induced Ca²⁺ release from ryanodin/caffeine-sensitive stores in bovine adrenal medullary cells via EP-₁-like receptors. J. Neurochem. 73:2167-2174

19.      Toyohira Y, Yanagihara N, Minami K, Ueno S, Uezono Y, Tachikawa E, Kondo Y, Kashimoto T, Izumi F. (1998) Down-regulation of the noradrenaline transporter by interferon-? in cultured bovine adrenal medullary cells J. Neurochem. 70:1441-1447

20.      Yoshimura R, Yanagihara N, Terao T, Uezono Y, Toyohira Y, Ueno S, Abe K, Izumi F. (1998) Carbamazepine-induced up-regulation of voltage-dependent Na⁺ channels in bovine adrenal medullary cells in culture. J. Pharmacol. Exp. Ther. 287: 441-447

21.      Yanagihara N, Toyohira Y, Yamamoto H, Ohta Y, Tsutsui M, Miyamoto E, Izumi F. (1994) Occurrence and activation of Ca²⁺/calmodulin-dependent protein kinase II and its endogenous substrates in bovine adrenal medullary cells. Mol. Pharmacol. 46 :423-430

22.      Yanagihara N, Toyohira Y, Koda Y, Wada A, Izumi F. (1991) Inhibitory effect of okadaic acid on carbachol-evoked secretion of catecholamines in cultured bovine adrenal medullary cells. Biochem. Biophys. Res. Commun. 174:77-83

23.      Izumi F, Toyohira Y, Yanagihara N, Wada A, Kobayashi H. (1986) Barium-evoked release of catecholamines from digitonin-permeabilized adrenal medullary cells. Neurosci. Lett. 69: 172-175

The Japanese Pharmacological Society