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The Radioisotope Research Center, which is one of the most important facilities for the development of medical and life sciences, is used for a variety of experiments by the faculty, and conducts training classes in safe handling of radiations and radioisotopes for the students and the new members of the faculty.
Its facilities are able to accommodate various types of experiments. This center is equipped with separate laboratories where students and staff members can conduct experiments safely with various types of radioisotopes.

Subjects for study

The following studies have been made in Radioisotope Research Center:

• Health effects of low-level radiation.
• Biological assessment of exposure to tritium beta rays.
• Transcription regulation of cytokine genes in hematopoietic cells.
• The mechanisms of adhesion molecules in immune system and inflammation, in the contexts with cytokines and proteoglycans.
• Characterization of molecular mechanisms of hormone resistance disorders in endocrine diseases.
• The pathogenesis and regulation of collagen-induced arthritis.
• The role of superantigen in the pathogenesis of autoimmune rheumatoid arthritis.
• Studies on biological role of metallothionein in immune response.
• Peptide leukotrienes such as LTC4, LTD4 and LTE4 were assayed in the samples of blood and tourniquet muscle at the tourniquet shock.
• Taxonomic study on marine bacteria.
• Biosynthesis of archaebacterial lipids.
• Estimation of telomerase activity with modified TRAP assay in oral cancer tissues.
• Alterations of expression of the cytoskeleton after immortalization of human fibroblasts.
• Molecular biological research on occupational lung disease.
• Regulation of mucin gene expression.
• Expression of the immediate early genes in the nervous system.
• Alterations of carnitine concentrations in the brain.
• Effects of neurotoxins on activities of membrane-bound enzymes.
• Remodeling of the artery after birth.
• Regulation of histamine-receptors in the artery.
• Mechanism for invasion and metastasis of human esophageal cancer.
• Regulation of catecholamine synthesis and secretion by protein kinases.
• Interactions among the nervous, endocrine and immune systems.
• Molecular and biochemical analysis of ion channels and receptors.
• Structure-function relationship of the sodium pump.
• Sex hormone receptors in gastroenterological cancers.
• Invasion and metastasis of cancer cells.
• Heat-shock(stress)protein.
• Apotosis.
• Immortalization.
• Fuzzy-set cloning for functional protein targeting and application to investigation of histo-reguratory proteins.
• Charactarization of active profilin and woundhealin during uncurable diseases.
• Gene expression of AVP in lithium induced diabetes insipidns.
• Signal transduction of vasoactive peptides in renal preparations.
• Anti mitogenetic effect of vasoactiv peptides in rat renal mesangial cells.
• 2-Hydroxyadenine as oxidative DNA damage: its formation and mutation inducibility.
• Formation of 8-hydroxyguanine in DNA by aging and oxidative stress.
• Increased 8-hydroxyguanine level in DNA and repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate.
• Increase of type of oxidative DNA damage, 8-hydroxyguanine and its repair activity in human leukocytes by cigarette smoking.
• Analyses of [35S]methionine-labeled peptides released from Weibel-Palade bodies of endothelial cells by two-dimensional polyacrylamide gel electrophoresis.
• The response of mechanically compressed cultured astrocytes.
• Analysis of the expression of heat shock protein gone in response to a variety of stresses and the regulation of its promoter region.
• Regulation of transcription of nuclear hormone receptor genes in neural cells.
• Identification of target genes of nuclear hormone receptors.
• Analysis of regulation mechanism on gene expression by in vivo footprinting.
• Measurement of telomerase activity: correlation between cancer and telomerase activity.
• The regulation of gene expression in the neuroendorine and immune system .
• The role of cardiovascular-related peptides and cytokines in neuroendocrine and immune system.
• In vitro expression of sea urchin (Hemicentrotus pulcherrimus) G-string binding protein.
• Sequence specific DNA binding assay of G-string binding protein using DNA affinity column.
• Effect of sleep, circadian rhythm, and shift work on allergic respiratory reaction.
• Role of anterior hypothalamus on allergic respiratory reaction.
• Stress and coping.

edited by Radioisotope Research Center

Last Update: Aug.16 2005