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Radiological Health Science
 

Department of Radiological Health Science

Professor: Ryuji Okazaki, MD, PhD

Associate Professor: Takashi Moritake, MD, PhD

Assistant Professor: Masaoki Kohzaki, PhD

 

Aim

The estimated time to decommission the Fukushima Daiichi Nuclear Power Plant (FDNPP) appears to be approximately 40 years. We therefore participate in the occupational health control for decommission and decontamination workers related with FDNPP. To accomplish this purpose, appropriate implementation of work management, work environment control, health care, employee training will be needed. We will bring up professional industrial hygienists, who can supervise and carry out adequately these educational contexts. Moreover, our laboratory will improve researches include Engineering for radiation dosimetry and protection, Radiation Biology for evaluating low-dose of Ionizing Radiation (IR) effect using mouse models, and Molecular Biology and Biochemistry for understanding molecular mechanisms of cancer caused by IR to achieve our purpose.

 

Research outlines

1. Epidemiological survey for workers related with FDNPP

Our laboratory is core members of the support team for the UOEH FDNPP workers and continuously supports radiation dosimetery and health examination. We obtained health examination data from the Tokyo Electric Power Company (TEPCO) and will analyze these data for evaluating relationship between health condition and exposed doses on workers objectively.

 

2. Evaluation for low-doses of IR using mouse model

Acquiring biological effect of low-doses of IR is technically difficult. We focus on Reactive Oxigen Species (ROS), which are caused by IR and induce DNA damage. We will analyze long-term effect of low-dose of IR using anti-oxidative stress assay in blood samples. In addition, we will use DNA repair and DNA damage checkpoint defect mice to evaluate low-doses of IR effect on cancer and aging in long-term context.

 

3. Radiation dosimetry and protection for Interventional Radiology (IVR)

Rapid development of therapeutic technology requires IR measurement and protection for patients and we are developing new devices for measurement and protection. In 2011, new ICRP report made new threshold criteria of lens opacity for occupational workers in medical field. Physicians who treat more than 70 surgeries per year will exceed the threshold. Therefore, we started comprehensive project to measure lens IR exposure in doctors, nurses, and radiologists all over Japan.

 

4. Molecular mechanism of cancer caused by IR

Based on epidemiological survey, it is clear that IR cause leukemia at early period (within 9 years) and various cancers at late period (30 to 40 years). However precise mechanism of cancer caused by IR remains to be elucidated. We use our established IR hypersensitive RecQL4 knock-in cell lines and elucidate why RecQL4 defect patients result in osteosarcoma and leukemia using moleculer boiology and biochemical approach.

 

Publications

 

・Ohguri T, Kunugita N, Yahara K, Imada H, Uemura H, Shinya N, Youjirou G, Takashi C, Okazaki R,

    Ootsuyama A, Korogi Y. Efficacy of hyperbaric oxygen therapy combined with mild hyperthermia for

    improving the anti-tumour effects of carboplatin. Int J Hyperthermia. 31(6):643-648, 2015

・Kohzaki M, Ootsuyama A, Moritake T, Abe T, Kubo T, Okazaki R. What have we learned from a

    questionnaire survey of citizens and doctors both inside and outside Fukushima? –Survey comparison

    between 2011 and 2013-. J Radiol Prot. 35(1):N1-N17, 2015

・Hong Z, Zenkoh J, Le B, Gerelchuluun A, Suzuki K, MoritakeT, Washio M, Urakawa J, Tsuboi K.

    Generation of low-flux X-ray micro-planar beams and their biological effect on a murine subcutaneous

    tumor model. J Radiat Res,56(5):768-76, 2015

・Ariungerel Gerelchuluun, Eri Manabe, Takaaki Ishikawa, Lue Sun, Kazuya Itoh, Takeji Sakae,Kenshi Suzuki,

    Ryoichi Hirayama, Aroumougame Asaithamby, David J. Chen and Koji Tsuboi. The Major DNA Repair

    Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in

    Carbon Ions. Radiation Research.183:345–356, 2015

・Mori K, Tateishi S, Kubo T, Okazaki R, Suzuki K, Kobayashi Y, Hiraoka K, Hayashi T, Takeda M, Kiyomoto Y,

    Kawashita F, Yoshikawa T, Sakai K, Transition of Occupational Health Issues Associated With Stabilization

    and Decommissioning of the Nuclear Reactors in the Fukushima Daiichi Nuclear Power Plant Through 2013,

    J OCCUP ENVIRON MED 56(11):1145-1152, 2014

・Okazaki R, Ootsuyama A.p53-dependent delayed effects of radiation vary according to time of irradiation of

    p53(+/-)mice. Journal of Radiation Research, 55(1):25-31, 2014

・Sun L, Mizuno Y, Iwamoto M, Goto T, Koguchi Y, Miyamoto Y, Tsuboi K, Chida K, Moritake T. Direct

 measurement of patient's entrance skin dose during pediatric cardiac catheterization, J Radiat Res.

    55(6):1122-1130, 2014

・Kato M, Chida K, Moritake T, Koguchi Y, Kaga Y, Sakamoto H, Tsukamoto A, Kawauchi S, Matsumoto K,

    Matsumura M, Oosaka H, Tosa T: Study on the development of a patient dosimetry gown for interventional

    cardiology procedures. Hoshasen Gijyutu Gakkasi Zasshi. 70(8):814-20, 2014

・Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka K, Mori Y,

    Tsuboi K, Sakurai H. RBE and OER within the spread-out Bragg peak for proton beam therapy,in vitro study

    at the Proton Medical Research Center at the University of Tsukuba. J Radiat Res. 55(5):1028-1032, 2014

・Kanemoto A, Okumura T, Ishikawa H, Mizumoto M, Oshiro Y, Kurishima K, Homma S, Hashimoto T,

    Ohkawa A, Numajiri H, Ohono T, Moritake T, Tsuboi K, Sakae T, Sakurai H. Outcomes and prognostic

    factors for recurrence after high-dose proton beam therapy for clinically and peripherally located stage I

    non-small-cell lung cancer. Clinical Lung Cancer. 15(2):e7-12, 2014

・Kato M, Chida K, Moritake T, Koguchi Y, Sato T, Oosaka H, Tosa T, Kadowaki K. Fundamental study on the

    characteristics of a radiophotoluminescence glass dosimeter with no energy compensation filter for measuring

    patient entrance doses in cardiac interventional procedures. Radiation Protection Dosimetry,

   162(3):224-229, 2014

・Suzuki K, Gerelchuluun A, Hong Z, Sun L, Zenkoh J, Moritake T, Tsuboi K. Celecoxib enhances

    radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress.

    Neuro Oncol. Sep;15(9):1186-99, 2013

・Hong Z, Kase Y, Moritake T, Gerelchuluun A, Sun L, Suzuki K, Terunuma T, Yasuoka K, Kumada H, Anzai K,

    Sakurai H, Sakae T, Tsuboi K. Lineal energy-based evaluation of oxidative DNA damage induced by proton

    beams and X-ray.  Int J Radiat Biol, 89(1):36-43, 2013

・Sun L, Moritake T, Yun-Wen Z, Suzuki K, Gerelchuluun A, Hong Z, Zenkoh J, Taniguchi H, Tsuboi K: In vitro

    stemness characterization of radioresistant clones isolated from a medulloblastoma cell line

    ONS-76. J. Radat. Res., 54(1):61-9, 2013

・Kanemoto A, Mizumoto M, Okumura T, Takahashi H, Hashimoto T, Oshiro Y, Fukumitsu N, Moritake T,

    Tsuboi K, Sakae T, Sakurai H. Dose-volume histogram analysis for risk factors of radiation-induced rib

    fracture after hypofractionated proton beam therapy for hepatocellular carcinoma.

    Acta Oncol, 52(3):538-44, 2013

・Kenshi Suzuki, Ariungerel Gerelchuluun, Zhengshan Hong, Lue Sun, Junko Zenkoh, Takashi Moritake, and

    Koji Tsuboi. Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic

    reticulum stress. Neuro-Oncology. 15(9):1186–99, 2013

・Zhengshan Hong, Yuki Kase, Takashi Moritake, Ariungerel Gerelchuluun, Lue Sun, Kenshi Suzuki,

    Toshiyuki Terunuma, Kiyoshi Yasuoka, Hiroaki Kumada, Kazunori Anzai, Hideyuki Sakurai, Takeji Sakae

    and Koji Tsuboi. Lineal energy-based evaluation of oxidative DNA damage induced by proton beams and

    X-rays. International Journal of Radiation Biology.89(1):36-43, 2013

・Mori K, Tateishi, S Hiraoka, K, Kubo T, Okazaki R, Suzuki K, Kobayashi Y, Kohno K. How Occupational

    Health Can Contribute at a Disaster and What Should Prepare for the Future? -Lessons Learned through

    Support Activities of a Medical School at the Fukushima Daiichi Nuclear Power Plant in Summer 2011.

    Journal of Occupational Health 55(1):6-10, 2013

・Okazaki R.Fukushima is not Chernobyl - The prognosis for Fukushima and the importance of education

    about radiation -, J UOEH 34 Supple:31-33, 2012

・Okazaki R, Ootsuyama A, Yoshida Y, Norimura T, Molecular Biology International, Establishment of

    methylation-specific PCR for the mouse p53 gene. vol. 2011, Article ID 938435, 4 pages, 2011