1. Harada M.
Diagnosis for Wilson disease: this disease may not be a rare disease.
Journal of Gastroenterology 56(1):114-115,2021

2. Koya Y, Shibata M, Watanabe T, Kumei S, Miyagawa K, Oe S, Honma Y, Kume K, Yoshikawa I, Harada M.
Influence of gastroesophageal flap valve on esophageal variceal bleeding in patients with liver cirrhosis.
Digestive Endoscopy 33(1):100-109,2021

3. Ogino N, Miyagawa K, Nagaoka K, Matsuura-Harada Y, Ogino S, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K.
Role of HO-1 against saturated fatty acid-induced oxidative stress in hepatocytes.
Nutrients 13(3):993,2021

5. Honma Y, Sato-Morita M, Katsuki Y, Mihara H, Baba R, Hino K, Kawashima A, Ariyasu T, Harada M.
Trehalose alleviates oxidative stress-mediated liver injury and Mallor-Denk body formation via activating autophagy in mice.
Medical Molecular Morphology 54(1):41-51,2021

6. Ogino N, Takahashi H, Nagaoka K, Harada Y, Kubo M, Miyagawa K, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K.
Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice.
Life Sciences 278:119588,2021

7. Honma Y, Miyagawa K, Hara Y, Hayashi T, Kusanaga M, Ogino N, Minami S, Oe S, Ikeda M, Hino K, Harada M.
Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Medical Molecular Morphology 54(2):108-121,2021

8. Koya Y, Shibata M, Oe S, Honma Y, Nebuya S, Miyagawa K, Yoshikawa I, Harada M.
Impact of sarcopenia on recurrent biliary obstruction after insertion of self-expandable metallic stent in patients with malignant biliary obstruction.
Journal of Hepato-biliary-pancreatic Sciences 28(7):572-580,2021

9. Naitoh I, Kamisawa T, Tanaka A, Nakazawa T, Kubota K, Takikawa H, Unno M, Masamune A, Kawa S, Nakamura S, Okazaki K,…Oe S, Harada M, Kurata M, Fukasawa M, Enomoto N, Kawaji Y, Kitano M, Nishise Y, Hirakawa H, Ishizawa T, Ueno Y, Kaino M, Fujimoto Y, Sakaida I, Kubota K.
Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort.
Digestive and liver disease 53(10):1308-1314,2021

10. Hayashi T, Watanabe T, Shibata M, Kumei S, Oe S, Miyagawa K, Honma Y, Harada M.
Endoscopic injection sclerotherapy improves liver function compared with endoscopic variceal ligation.
Scientific Reports 11(1):20479,2021

11. Kumei S, Sakurai T, So S, Itaba S, Akiho H, Nakamura S, Kim H, Yamasaki M, Takatsu N, Maekawa R, Sakemi R, Watanabe T, Shibata M, Kume K, Yoshikawa I, Takaki Y, Harada M.
Impact of the concomitant use of immunomodulator and a lower week 8 partial Mayo score on the persistence of adalimumab in refractory ulcerative colitis.
Internal Medicine 60(24):3849-3856,2021

12. Kusanaga M, Tokutsu K, Narita M, Ishikawa S, Muramatsu K, Matsuda S, Mayumi T.
Early enteral nutrition is related to decreased in-hospital mortality and hospitalization in patients with acute pancreatitis: data from the Japanese diagnosis procedure combination database.
Journal of UOEH 43(3):313-321,2021

13. Ogino N, Miyagawa K, Nagaoka K, Sumida K, Kusanaga M, Oe S, Honma Y, Shibata M, Harada M, Suganuma N, Ogino K.
Airborne fine particulate matter in Japan induces lipid synthesis and inhibits autophagy in HepG2 cells.
The International Journal of Biochemistry & Cell Biology 141:106099,2021

14. Klionsky DJ, …Harada M, …Tong CK.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Autophagy 17(1):1-382,2021

15. Honma Y, Shibata M, Gohda T, Matsumiya H, Kumamoto K, Miyama A, Morino K, Koya Y, Taira A, Shinohara S, Hayashi T, Kusanaga M, Oe S, Miyagawa K, Abe S, Tanaka F, Harada M.
Rapid progression of liver fibrosis induced by acute liver injury due to immune-related adverse events of atezolizumab.
Internal Medicine 60(12):1847-1853,2021

16. Honma Y, Karasuyama T, Kumamoto K, Shimajiri S, Toki Y, Tatsumi Y, Sumida K, Koikawa K, Morino K, Oe S, Miyagawa K, Yamasaki M, Shibata M, Abe S, Ikuta K, Hayashi H, Harada M.
Type 4B hereditary hemochromatosis due to heterozygous p.D157A mutation in SLC40A1 complicated with hypopituitarism.
Medical Molecular Morphology 54(1):60-67,2021

17. Hideshima K, Watanabe T, Miyashima Y, Kumei S, Kume K, Yoshikawa I, Harada M.
Meckel's diverticulum bleeding missed by the first but detected by the second capsule endoscopy.
Journal of UOEH 43(1):75-80,2021

18. Karasuyama T, Honma Y, Kumamoto K, Shibata M, Watanabe T, Shimajiri S, Abe S, Yamashita T, Harada M.
Hepatocyte growth factor and primary systemic amyloidosis.
Journal of UOEH 43(2):227-233,2021

19. Imazu N, Oe S, Tsuda Y, Nebuya S, Koya Y, Miyagawa K, Honma Y, Shibata M, Harada M.
Rapidly progressing anaplastic carcinoma of the pancreas with mucoepidermoid carcinoma: An autopsy case report.
IInternal Medicine 60(14):2235-2240,2021

1. Takeda T, So S, Sakurai T, Nakamura S, Yoshikawa I, Yada S, Itaba S, Yamagata H, Akiho H, Takatsu N, Wada Y, Ohtsu K, Nagahama T, Yao K.
Learning effect of diagnosing depth of invasion using Non-Extension sign in early gastric cancer.
Digestion 101(2):191-197,2020

2. Honda H, Kato H, Olsen M A, Reske K A, Senoh M, Fukuda T, Tagashira Y, Mahe C, Dubberke E R, Horiuchi H, Chiba H, Suzuki D, Hosokawa N, Kitazono H, Norisue Y, Kume H, Mori N, Morikawa H, Kashiwagura S, Higuchi A, Kato H, Nakamura M, Ishiguro S, Morita S, Ishikawa H, Watanabe T, Kojima K, Yokomaku I, Bando T,Toimoto K, Moriya K, Kasahara K, Kitada S, Ogawa J, Saito H, Tominaga H, Tominaga H, Shimizu Y, Masumoto F, Tadera K, Yoshida J, Kikuchi T, Yoshikawa I, Watanabe T, Honda M, Yokote K, Toyokawa T, Miyazato H, Nakama M.
Risk factors for Clostridioides difficile infection in hospitalized patients and associated mortality in Japan: a multi-centre prospective cohort study.
The Journal of Hospital Infection 104(3):350-357,2020

3. Hayashi T, Tamaki N, Kurosaki M, Wang W, Okada M, Higuchi M, Takaura K, Takada H, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Harada M, Izumi N.
Use of the serum wisteria floribunda agglutinin-positive Mac2 binding protein as a marker of gastroesophageal varices and liver-related events in chronic hepatitis c patients.
Diagnostics 10(3):173,2020

5. Narita R, Kotoh K, Yoneda A, Motomura M, Harada M.
Factors raising serum ammonia level during lenvatinib treatment of patients with hepatocellular carcinoma.
Anticancer Research 40(9):5271-5276,2020

6. Hayashi T, Shibata M, Oe S, Miyagawa K, Honma Y, Harada M.
Antiplatelet therapy improves the prognosis of patients with hepatocellular carcinoma.
Cancers 12(11):3215,2020

7. Hayashi T, Shibata M, Oe S, Miyagawa K, Honma Y, Harada M.
C-reactive protein can predict dose intensity, time to treatment failure and overall survival in HCC treated with lenvatinib.
PLoS One 15(12):e0244370,2020

8. Oe S, Honma Y, Yabuki K, Morino K, Kumamoto K, Hayashi T, Kusanaga M, Ogino N, Minami S, Shibata M, Abe S, Harada M.
Importance of a liver biopsy in the management of Wilson dsease.
Internal Medicine 59(1):77-81,2020

9. Koya Y, Watanabe T, Kume K, Kumei S, Yoshikawa I, Tasaki T, Harada M.
Usefulness of magnifying endoscopy and endoscopic ultrasonography for the gastric involvement of follicular lymphoma.
Clinical Journal of Gastroenterology 13(1):55-59,2020

10. Imazu N, Shibata M, Koya Y, Morino K, Honma Y, Senju M, Watanabe T, Harada M.
Hepatic inflammatory pseudotumor protruding from the liver surface and directly penetrating the colon.
Internal Medicine 59(4):527-532,2020

11. Harada M, Honma Y, Yoshizumi T, Kumamoto K, Oe S, Harada N, Tanimoto A, Yabuki K, Karasuyama T, Yoneda A, Shibata M.
Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?
Medical Molecular Morphology 53(1):50-55,2020

1. Harada M.
Chapter 5　Liver cirrhosis with inherited liver disease:Wilson disease.
The evolving landscape of liver cirrhosis management. pp.59-67,2019

2. Hitomi Y, Ueno K, Kawai Y, Nishida N, Kojima K, Kawashima M, Aiba Y, Nakamura H, Kouno H, Ohta H, Sugi K, Nikami T, Yamashita T, Katsushima S, Komeda T, Ario K, Naganuma A, Shimada M, Hirashima N, Yoshizawa K, Makita F, Furuta K, Kikuchi M, Naeshiro N, Takahashi H, Mano Y, Yamashita H, Matsushita K, Tsunematsu S, Yabuuchi I, Nishimura H, Shimada Y, Yamauchi K, Komatsu T, Sugimoto R, Sakai H, Mita E, Koda M, Nakamura Y, Kamitsukasa H, Sato T, Nakamuta M, Masaki N, Takikawa H, Tanaka A, Ohira H, Zeniya M, Abe M, Kaneko S, Honda M, Arai K, Arinaga-Hino T, Hashimoto E, Taniai M, Umemura T, Joshita S, Nakao K, Ichikawa T, Shibata H, Takaki A, Yamagiwa S, Seike M, Sakisaka S, Takeyama Y, Harada M, Senju M, Yokosuka O, Kanda T, Ueno Y, Ebinuma H, Himoto T, Murata K, Shimoda S, Nagaoka S, Abiru S, Komori A, Migita K, Ito M, Yatsuhashi H, Maehara Y, Uemoto S, Kokudo N, Nagasaki M, Tokunaga K, Nakamura M.
POGLUT1,the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.
Scientific Reports. 9(1):102,2019

3. Hirai F, Ishida T, Takeshima F, Yamamoto S, Yoshikawa I, Ashizuka S, Inatsu H, Mitsuyama K, Sou S, Iwakiri R, Nozaki R, Ohi H, Esaki M, Iida M, Matsui T.
Effect of a concomitant elemental diet with maintenance anti-tumor necrosis factor-α antibody therapy in patients with Crohn's disease: A multicenter, prospective cohort study.
Journal of gastroenterology and hepatology.34(1):132-139

5. Nakano M, Koga H, Ide T, Kuromatsu R, Hashimoto S, Yatsuhashi H, Seike M, Higuchi N, Nakamuta M, Shakado S, Sakisaka S, Miuma S, Nakao K, Yoshimaru Y, Sasaki Y, Oeda S, Eguchi Y, Honma Y, Harada M, Nagata K, Mawatari S, Ido A, Maeshiro T, Matsumoto S, Takami Y, Sohda T, Torimura T.
Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study.
Cancer Medicine. 8(5):2646-2653,2019

6. Kusanaga M, Oe S, Ogino N, Minami S, Miyagawa K, Honma Y, Harada M.
Zinc attenuates the cytotoxicity of some stimuli by reducing endoplasmic reticulum stress in hepatocytes.
International Journal of Molecular Sciences 20(9):2192,2019

7. Kumei S, Nakayama T, Watanabe T, Kumamoto K, Noguchi H, Shibata M, Kume K, Yoshikawa I, Harada M.
Impact of examining additional deeper sections on the pathological diagnosis of endoscopically resected early gastric cancer.
Digestive Endoscopy. 31(4):405-412,2019

8. Honma Y, Shibata M, Hayashi T, Kusanaga M, Ogino N, Minami S, Kumei S, Oe S, Miyagawa K, Senju M, Matsuoka H, Watanabe T, Hiura M, Abe S, Harada M.:
Effect of direct-acting antivirals on platelet-associated immunoglobulin G and thrombocytopenia in hepatitis C virus-related chronic liver disease.
Liver International 39(9):1641-1651,2019

9. Kume K, Sakai N, Ueda T.
Development of a novel gastrointestinal endoscopic robot enabling complete remote control of all operations: endoscopic therapeutic robot system (ETRS).
Gastroenterology research and practice 6909547,2019

10. Kato H, Senoh M, Honda H, Fukuda T, Tagashira Y, Horiuchi H, Chiba H, Suzuki D, Hosokawa N, Kitazono H, Norisue Y, Kume H, Mori N, Morikawa H, Kashiwagura S, Higuchi A, Kato H, Nakamura M, Ishiguro S, Morita S, Ishikawa H, Watanabe T, Kojima K, Yokomaku I, Bando T, Toimoto K, Moriya K, Kasahara K, Kitada S,Ogawa J, Saito H, Tominaga H, Shimizu Y, Masumoto F, Tadera K, Yoshida J, Kikuchi T, Yoshikawa I, Watanabe T, Honda M, Yokote K, Toyokawa T, Miyazato H, Nakama M, Mahe C, Reske K, Olsen M A, Dubberke ER:
Clostridioides (Clostridium) difficile infection burden in Japan: A multicenter prospective study.
Anaerobe 60:102011,2019

11. Ogino N, Miyagawa K, Kusanaga M, Hayashi T, Minami S, Oe S, Honma Y, Harada M.
Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes.
Experimental Cell Research :385(1):111651,2019

12. Senoh M, Kato H, Honda H, Fukuda T, Tagashira Y, Horiuchi H, Chiba H, Suzuki D, Hosokawa N, Kitazono H, Norisue Y, Kume H, Mori N, Morikawa H, Kashiwagura S, Higuchi A, Kato H, Nakamura M, Ishiguro S, Morita S, Ishikawa H, Watanabe T, Kojima K, Yokomaku I, Bando T, Toimoto K, Moriya K, Kasahara K, Kitada S,
Performance of laboratory tests for detection for Clostridioides difficile
A multicenter prospective study in Japan.Anaerobe 60:102107,2019

13. Koya Y, Suzuki T, Tai M, Ichii O, Matsuhashi N, Ejiri Y, Miyazawa M, Shibata M, Harada M, Kumabe T, Nakashima O.
Inflammatory hepatocellular adenoma with elevated serum protein Induced by vitamin K absence/antagonist-II in adult males.
Internal Medicine. 58(12):1739-1746,2019

14.Koya Y, Shibata M, Senju M, Honma Y, Hiura M, Ishii M, Matsumoto S, Harada M.:
Hyperammonemia in a woman with late-onset ornithine transcarbamylase deficiency.
Internal Medicine. 58(7):937-942,2019

15. Koya Y, Shibata M, Shinohara N, Nebuya S, Oe S, Honma Y, Senju M, Sato N, Harada M.
Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work.
Hepatology Research. 49(8):950-956,2019

1. Honma Y, Sato-Morita M, Katsuki Y, Mihara H, Baba R, Harada M.
Trehalose activates autophagy and decreases proteasome inhibitor-induced endoplasmic reticulum stress and oxidative stress-mediated cytotoxicity in hepatocytes.
Hepatology Research 48(1):94-105,2018

2. Miyashima Y, Iwamuro M, Shibata M, Miyabe Y, Kawai Y, Kaihara M, Mitogawa T, Harada M.
Prediction of disseminated intravascular coagulation by liver function tests in patients with japanese spotted fever.
Internal Medicine 57(2):197-202,2018

3. Morino K, Honma Y, Kumei S, Watanabe T, Kume K, Yoshikawa I, Harada M.
Recombinant thrombomodulin used to successfully treat Cronkhite-Canada syndrome with disseminated intravascular coagulation due to sepsis in a compromised patient: A case report.
Internal Medicine 57:3079-3085,2018

4. Honma Y, Sumida K, Ogino N, Kusanaga M, Minami S, Kumei S, Matsuoka H, Watanabe T, Hiura M, Abe S, Shibata M, Harada M.
A young adult patient with nonalcoholic steatohepatitis developed severe gastroesophageal varices associated with severe obesity and diabetes mellitus.
Case Reports in Gastroenterology 12(2):487-496,2018

5. Koya Y, Suzuki T, Tai M, Ichii O, Matsuhashi N, Ejiri Y, Shibata M, Harada M.
Spontaneous regression of hepatocellular carcinoma with portal vein tumor thrombus.
Case Reports in Gastroenterology 12(2):411-419,2018

6. Kume K, Sakai N, Goto T.
Haptic feedback is useful in remote manipulation of flexible endoscopes.
Endoscopy International Open 6(9):E1134-E1139,2018

1. Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, …Nakamura M.
Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.
Human Molecular Genetics 26(3):650-659,2017

2. Masamune A, Nishimori I, Kikuta K, Tsuji I,  Mizuno N, Iiyama T, Kanno A,Tachibana Y, Ito T, Kamisawa T, Uchida K, Hamano H, Yasuda H, Sakagami J, Mitoro A, Taguchi M,Kihara Y, Sugimoto H, Hirooka Y, Yamamoto S, Inui K, Inatomi O, Andoh A, Nakahara K,Miyakawa H, Hamada S, Kawa S, Okazaki K, Shimosegawa T, for the Research Committee of Intractable Pancreas Diseases in Japan.
Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis.
Gut 66:487–494,2017

3.Harada M.
Management for acute liver failure of Wilson disease: Indication for liver transplantation.
Hepatology Research 47(4):281-282,2017

5. Harada M, Yoneda A, Haruyama S, Yabuki K, Honma Y, Hiura M, Shibata M, Matsuoka H, Uchiwa Y.
Bullous pemphigoid associated with the dipeptidyl peptidase-4 inhibitor sitagliptin in a patient with liver cirrhosis complicated with rapidly progressive hepatocellular carcinoma.
Internal Medicine 56(18):2471-2474,2017

6. Miyashima Y, Shibata M, Honma Y, Matsuoka H, Hiura M, Abe S, Harada M.
Severe alcoholic hepatitis effectively treated with vitamin E as an add-on to
corticosteroids.
Internal Medicine 56(24):3293-3297,2017

1. klionsky DJ, Abdelmohsen K, Abe A, … Harada M, … Zughaier SM.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy 12(1):1-222,2016

2. Wei L, Yamamoto M, Harada M, Otsuki M.
Treatment with atorvastatin attenuates progression of insulin resistance and　pancreatic fibrosis in the Otsuka Long-Evans Tokushima fatty rats.
Metabolism 65(2):41-53,2016

3. Ogino N, Aridome G, Oshima J, Shibata M, Watanabe T, Kume K, Yoshikawa I,Harada M.
Serum Albumin Concentrations Predict hypovolaemia Caused by Polyethylene Glycol Plus　Ascorbic Acid Prior to Colonoscopy in Elderly Patients.
Drugs Aging 33(5):355-363,2016

4. Hino K, Harada M.
Metal Metabolism and Liver 
Editor：Ohira H.
“The Liver in Systeminc Diseases”　Springer  pp.123-146,2016

5. Miyagawa K, Oe S, Honma Y, Izumi H, Baba R, Harada M.
Lipid-induced endoplasmic reticulum stress impairs selective autophagy at the step of autophagosome-lysosome fusion in hepatocytes.
The American Journal of Pathology 186(7):1861-1873,2016

6. Oe S, Miyagawa K, Honma Y, Harada M.
Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease.
Experimental Cell Research 347(1):192-200,2016

7. Ide T, Eguchi Y, Harada M, Ishii K, Morita M, Morita Y, Sugiyama G, Fukushima H,Yano Y, Noguchi K, Nakamura H, Hisatomi J, Kumemura H, Shirachi M, Iwane S, Okada M, Honma Y, Arinaga-Hino T, Miyajima I, Ogata K, Kuwahara R, Amano K, Kawaguchi T, Kuromatsu R, Torimura T, DAAs Multicenter Study Group.
Evaluation of Resistance-Associated substitutions in NS5A using direct sequence and　cycleave method and treatment outcome with daclatasvir and asunaprevir for chronic hepatitis C Genotype 1. 
PLOS ONE 11(9):1-11  DOI:10.1371/journal.pone.0163884,2016

8.Kume K.
Flexible robotic endoscopy:current and original devices.
Computer Assisted Surgery 21(1):150-159 ,2016

9.Miyashima Y, Honma Y, Miyagawa K, Oe S, Senju M, Shibata M, Hiura M, Abe S,
Harada M.
Daclatasvir and Asunaprevir Combination Therapy-induced Hepatitis and Cholecystitis with Coagulation Disorder due to Hypersensitivity Reactions.
Internal Medicine 55(24):3595-3601,2016

1. Oki H, Hayashida Y, Oki H, Kakeda S, Aoki T, Taguchi M,Harada M, Korogi Y.
DWI findings of autoimmune pancreatitis: comparison between symptomatic and asymptomatic patients.
Journal of Magnetic Resonance Imaging  41(1):125-131,2015

2. Shibata M, Hiura M, Senju M, Matsuhashi T, Abe S, Morita C, Hayashida K, Tabaru A, Harada M.
Hepatic peribiliary cysts with rapidly progressive refractory obstructive jaundice and esophageal varices.
Internal Medicine 54(4):389-393,2015

3. Miyagawa K, Shibata M, Noguchi H, Hayashi T, Oe S, Hiura M, Abe S, Harada M.
Methotrexate-related primary hepatic lymphoma in a patient with rheumatoid arthritis.
Internal Medicine 54(4):401-405,2015

4. Kume K, Kuroki T, Shingai M.
Development of a novel endoscopic manipulation system: The Endoscopic Operation Robot ver. 2.
Hepatogastroenterology 62(140):843-845,2015

5. Kimura S, Wang K, Yamada S, Guo X, Nabeshima A, Noguchi H, Watanabe T, Harada M, Sasaguri Y.
CCL22/Macrophage-derived chemokine expression in apolipoprotein E-deficient mice and effects of histamine in the setting of atherosclerosis.
Journal of Atherosclerosis and Thrombosis 22(6):599-609,2015

6. Watanabe T, Kume K, Yoshikawa I, Harada M.
Usefulness of a novel calibrated hood to determine indications for colon polypectomy:
visual estimation of polyp size is not accurate.
International Journal of Colorectal Disease 30(7):933-938,2015

7. Kumei S, Onishi Y, Ogura T, Kusumoto C, Matsuno Y, Nishigami T, Maeda M, Harada M.
Carcinosarcoma of the extrahepatic bile duct presenting with stone-like radiological
findings.
Internal Medicine 54(14):1747-1751,2015

8. Oe S, Shibata M, Miyagawa K, Honma Y, Hiura M, Abe S, Harada M.
Hepatitis A complicated with acute renal failure and high hepatocyte growth factor : A case report.
World Journal of Gastroenterology 21(32)：9671-9674,2015

9. Kume K, Sakai N, Goto T.
Development of a novel endoscopic manipulation system: The Endoscopic Operation Robot ver. 3.
Endoscopy 47(9):815-819,2015

10. Minami S, Shibata M, Matsuhashi T, Hiura M, Abe S, Harada M.
Acute liver failure complicated with severe heart failure.
Internal Medicine 54(19):2443-2447,2015

11. Hiura M, Honma Y, Miyagawa k, Oe S, Shimajiri S, Mihara H, Oe M, Sato-Morita M, Katsuki Y, Harada M.
Alleviation mechanisms against hepatocyte oxidative stress in patients with chronic hepatic disorders. 
Hepatology Research 45(11):1124-1135,2015

1. Harada M.
Pathogenesis and management of Wilson disease.
Hepatology Research 44(4)：395-402,2014

2. Honma Y, Shimizu S, Takehara T, Harada M.
Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of
Akt and stress-activated protein kinases.
Journal of Gastroenterology 49(3)：517-526,2014

3. Kume K,Watanabe T, Oshima J, Yoshikawa I, Harada M.
Rectal perforation caused by mesalazine enema in a patient with ulcerative colitis.
Endoscopy 46：E190,2014

4. Kume K, Watanabe T, Yoshikawa I, Harada M.
Endoscopic measurement of polyp size using a novel calibrated hood.
Gastroenterology Research and Practice Article ID 714294,2014

5. Oe S, Watanabe T, Kume K, Shibata M, Hiura M, Yoshikawa I, Harada M.
A case of idiopathic gastroesophageal submucosal hematoma and its disappearance
observed by endoscopy.
JOURNAL OF UOEH 36(2)：123-128,2014

6. Kume K.
Endoscopic therapy for early gastric cancer:Standard techniques and recent advances in ESD.
World Journal of Gastroenterology 20(21):6425-6432,2014

7. Kume K, Takahashi S, Kumamoto K, Watanabe T, Yoshikawa I, Harada M.
Endoscopic resection of a giant pedunculated polyp using scissor-type forceps.
Endoscopy 46：E290-E291,2014

8. Taguchi M, Kubo T, Yamamoto M, Muramatsu K, Yasunaga H,
Horiguchi H, Fujimori K, Matsuda S, Fushimi K, Harada M.
Body mass index influences the outcome of acute pancreatitis.
An analysis based on the Japanese administrative database.
Pancreas 43(6)：863-866,2014

9. Oe S, Shibata M, Hiura M, Mitsuoka H, Matsuhashi T, Narita R,
Abe S, Tabaru A, Hayashida K, Taniguchi H, Harada M.
Refractory primary hepatic actinomycosis with direct infiltration to the diaphragm
and thorax : The usefulness of contrast-enhanced ultrasonography.
Internal Medicine 53(18):2073-2078,2014

10. Honma Y, Harada M.
A new therapeutic strategy for hepatocellular carcinoma by molecular targeting agents
via inhibition of cellular stress defense mechanisms.
JOURNAL OF UOEH 36(4)：229-235,2014

1. Kume K.
Endoscopic Resection with Cap-Assisted Endoscopic Mucosal Resection
The Expert’s Approach.
Video Journal and Encyclopedia of GI Endoscopy 1(1):130-132,2013

2. Honma Y, Harada M.
Sorafenib enhances proteasome inhibitor-mediated cytotoxicity
via inhibition of unfolded protein response and keratin phosphorylation.
Experimental Cell Research 319(14)：2166-2178,2013

3. Oki H, Hayashida Y, Oki H, Kakeda S, Aoki T, Taguchi M, Harada M, Korogi Y.
DWI findings of autoimmune pancreatitis
Comparison between symptomatic and asymptomatic patients.
Journal of Magnetic Resonance Imaging,2013

4. Yukawa S, Takeuchi M, Nakazono A, Sakamoto K, Araya K, Eto M,
Nishimura Y, Harada M, Levine R A, Otsuji Y.
Mitral stenosis reversed by medical treatment for heart failure.
The Society of Thoracic Surgeons 96(5)：E115-117,2013

1. Taura N, Fukushima N, Yatsuhashi H, Takami Y, Seike M, Watanabe H,
Mizuta T, Sasaki Y, Nagata K, Tabaru A, Komorizono Y, Taketomi A,
Matsumoto S, Tamai T, Muro T, Nakao K, Fukuizumi K, Maeshiro T,
Inoue O, Sata M.
The incidence of hepatocellular carcinoma associated with hepatitis C
infection decreased in Kyushu area.
Medical Science Monitor 17(2):7-11,2011

2. Hayashi H, Narita R, Hiura M, Abe S, Tabaru A, Tanimoto A, Sasaguri Y,
Harada M.
A case of adult autoimmune hepatitis with histological features of
giant cell hepatitis.
Internal Medicine 50(4):315-319,2011

3. Wei L, Yamamoto M, Harada M, Otsuki M.
Treatment with pravastatin attenuates progression of chronic
pancreatitis in rat.
Laboratory Investigation 91(6):872-884,2011

4. Kume K, Yamasaki M, Yoshikawa I, Harada M.
Infliximab treatment in a patient with Crohn's disease on haemodialysis.
Colorectal Disease 13(3):341-341,2011

5. Honma Y, Harada M, Sato M, Katsuki Y, Hiura M, Shibata M,
Narita R, Harada R, Abe S, Tabaru A, Tajiri N, Shimajiri S.
Late diagnosed Wilson disease with hepatic and neurological
manifestations.
Hepatology Research 41(3):270-276,2011

6. Yamamoto K, Hiura M, Tabaru A, Honma Y, Narita R, Abe S,
Shimajiri S, Okamoto K, Yamaguchi K, Harada M.
Rapid progression of hepatocellular carcinoma in a patient with
autoimmune hepatitis.
Internal Medicine 50(13):1409-1413,2011

7. Yanagimoto C, Harada M, Kumemura H, Abe M, Koga H, Sakata M, Kawaguchi T,
Terada K, Hanada S, Taniguchi E, Ninomiya H, Ueno T, Sugiyama T, Sata M.
Copper incorporation into ceruloplasmin is regulated by Niemann-Pick
C1 protein.
Hepatology Research 41(5):484-491,2011

8. Hiura M, Abe S, Tabaru A, Shimajiri S, Hanami K, Saito K,
Tanaka Y, Harada M.
Case of severe liver damage after the induction of tocilizumab
therapy for rheumatoid vasculitis.
Hepatology Research 41(5):492-496,2011

9. Kawaguchi T, Kakuma T, Yatsuhashi H, Watanabe H, Saitsu H, Nakao K,
Taketomi A, Ohta S, Tabaru A, Takenaka K, Mizuta T, Nagata K, Komorizono Y,
Fukuizumi K, Seike M, Matsumoto S, Maeshiro T, Tsubouchi H, Muro T,
Inoue O, Akahoshi M, Sata M.
Data mining reveals complex interactions of risk factors and clinical
feature profiling associated with the staging of non-hepatitis B
virus/non-hepatitis C virus-related hepatocellular carcinoma.
Hepatology Research 41(6):564-571,2011

10. Kume K, Kuroki T, Sugihara T, Shinngai M.
Development of a novel endoscopic manipulation system: The Endoscopic
operation robot.
World Journal of Gastrointestinal Endoscopy 3(7):145-150,2011

11. Harada M, Miyagawa K, Honma Y, Hiura M, Shibata M, Matsuhashi T,
Abe S, Harada R, Tabaru A.
Excess copper chelating therapy for Wilson disease induces anemia and
liver dysfunction.
Internal Medicine 50(14):1461-1464,2011

12. Sakemi M, Sakemi R, Harada M, So S, Uchiyama D, Morimitsu Y, Kakiuchi S,
Ishihara Y, Kubo Y, Matsugaki S, Ono T, Takane J, Sasaki E, Shimokobe M,
Sata M.
A case of postirradiation angiosarcoma of the greater omentum
with hemorrhage.
Clinical Journal of Gastroenterology 4(5):302-306,2011

13. Kume K, Yamasaki M, Watanabe T, Yoshikawa I, Otsuki M, Harada M.
Mild collateral varices and a fundic plexus without perforating
veins on EUS predict endoscopic non-recurrence of esophageal
varices after EVL.
Hepato-Gastroenterology 58(107):798-801,2011

14. Kume K.
EMR and ESD for gastrointestinal neoplasms.
Edited by Oliviu Pascu and Andrada Seicean
「New Techniques in Gastrointestinal Endoscopy」
In Tech,Croatia　pp.19-40,2011

15. Yamaguchi S, Ohguri T, Imada H, Yahara K, Moon SD, Higure A,
Yamaguchi K, Yoshikawa I, Harada M, Korogi Y.
Multimodal approaches including three-dimensional conformal re-irradiation
for recurrent or persistent esophageal cancer: preliminary results.
Journal of Radiation Research 52(6):812-820,2011

16. Kawaguchi T, Kaji R, Horiuchi H, Shirono T, Ishida Y, Okabe Y, Itou M,
Mitsuyama K, Akiba J, Nakashima O, Yano H, Kage M, Harada M, Sakisaka S,
Sata M.
Development of intrahepatic cholangiocarcinoma after a 14-year follow-up
of a patient with primary sclerosing cholangitis and ulcerative colitis.
Hepatology Research 41(12):1253-1259,2011

1. Kawaguchi T, Yamagishi S, Itou M, Okuda K, Sumie S, Kuromatsu R, Sakata M, Abe M, Taniguchi E, Koga H, Harada M, Ueno T, Sata M.
Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.
The American Journal of Pathology 176(1):168-176,2010.

2. Otani M, Yamamoto M, Harada M, Otsuki M.
Effect of long-and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima Fatty rat.
British Journal of Pharmacology 159(2):462-473,2010.

3. Miyamoto T, Nakamura H, Nagashio Y, Asaumi H, Harada M, Otsuki M.
Overexpression of Smad6 exacerbates pancreatic fibrosis in murine caerulein-induced chronic pancreatic injuries.
Pancreas 39(3):385-391,2010.

4. Ito T, Otsuki M, Igarashi H, Kihara Y, Kawabe K, Nakamura T, Fujimori N, Oono T, Takayanagi R, Shimosegawa T, The Research Committee of Intractable.
Epidemiological study of pancreatic diabetes in Japan in 2005 A nationwide study.
Pancreas 39(6):829-835,2010.

5. Kume K, Sakata H.
Gastrointestinal:Colonic foreign bodies needing surgical removal.
Journal of Gastroenterology and Hepatology 25(4):839,2010.

6. Harada M.
Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies,in hepatocytes.
Medical Molecular Morphology 43(1):13-18,2010.

7. Harada M.
Wilson disease and its current problems.
Internal Medicine 49(9):807-808,2010.

8. Kume K.
Endoscopic submucosal dissection using a novel vibration endoscopy.
Hepato-Gastroenterology 57(98):224-227,2010.

9. Watanabe T, Kume K, Tai M, Shibata M, kubo H, Ejiri Y, Otsuki M.
Gastric mucosal cancer smaller than 7mm can be treated with conventional endoscopic mucosal resection as effectively as with endoscopic submucosal dissection.
Hepato-Gastroenterology 57(99):668-673,2010.

10. Sakata M, Kawaguchi T, Taniguchi E, Nakayama A, Ishizaki S, Sonaka I, Maganuma M, Nakamura T, Itou M, Oriishi T, Abe M, Yanagimoto C, Koga H, Harada M, Sakamoto T, Oda S, Sata M.
Redox state of albumin is not associated with colloid osmotic pressure.
Molecular Medicine Reorts 3(4):685-687,2010.

11. Taguchi M, Nagashio Y, Kihara Y, Hiura M, Abe S, Yamamoto M, Harada M.
Three cases of locally advanced pancreatic cancer successfully treated with chemoradiation and chemotherapy.
Clinical Journal of Gastroenterology 3(4):186-190,2010.

12. Hiura M, Onizuka R, Narita R, Abe S, Tabaru A, Harada M.
A case of severe acute hepatitis C and delayed antibody production due to rituximab therapy.
Clinical Journal of Gastroenterology 3(5):254-258,2010.

13. Fusasaki T, Narita R, Hiura M, Abe S, Tabaru A, Hino R, Matsuyama A, Shimajiri S, Tokura Y, Sasaguri Y, Harada M.
Acute hepatic failure secondary to extensive hepatic replacement by metastatic amelanotic melanoma: an autopsy case report.
Clinical Journal of Gastroenterology 3(6):327-331,2010.

1. Kume K, Yoshikawa I, Harada M.
A rare complication: incarceration of a colonoscope in an inguinal hernia.
Endoscopy 41(Suppl 2):E172,Epub 2009.

2. Kume K, Yoshikawa I.
Rectal stenosis caused by cytomegalovirus colitis.
Endoscopy 41(Suppl 2):E197,Epub 2009.

3. Kume K.
Endoscopic therapy using novel fan devices.
Endoscopy 41(Suppl 2):E236-E237,2009.

4. Kume K, Sakata H, Yoshikawa I, Watanabe T, Harada M.
Polypectomy of a colonic muco-submucosal elongated polyp.
Endoscopy 41(Suppl 2):E265-E266,Epub 2009.

5. Kume K.
Endoscopic aspiration mucosectomy using a novel vibration hood.
Endoscopy 41(Suppl 2):E296-E298,2009.

6. Yanagimoto C, Harada M, Kumemura H, Kawaguchi T, Terada K, Hanada S, Taniguchi E, Koizumi Y, Koyota S, Ninomiya H, Ueno T, Sugiyama T, Sata M.
Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides.
Experimental Cell Research 315(2):119-126,2009.

7. Taguchi M, Kihara Y, Nagashio Y,Yamamoto M, Otsuki M, Harada M.
Decreased production of immunoglobulin M and A in autoimmune Pancreatitis.
Journal of Gastroenterology 44(11): 1133-1139,2009.

8. Kume K, Yamasaki M, Yoshikawa I.
Sepsis caused by endoscopic clipping for colonic diverticular bleeding: A rare complication.
World Journal of Gastroenterology 15(30):3820-3821,2009.

9. Yoshikawa I, Nagato M, Yamasaki M, Kume K, Otsuki M.
Long-term treatment with proton pump inhibitor is associated with undesired weight gain.
World Journal of Gastroenterology 15(38):4794-4798,2009.

10. Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Otsuki M, Otsuji Y.
Hepatic angiosarcoma-a rare liver tumor in a hemodialysis patient.
Clinical Nephrology 71(5):590-592,2009.

11. Kume K.
The local recurrence and the metachronous cancer after EMR for early esophageal cancer confined within the lamina propria mucosae.
Hepato-Gastroenterology 56(91-92):699-702,2009.

12. Kume K.
EMR and ESD for early gastric cancer : Current and original devices.
World Journal of Gastrointestinal Endoscopy 1(1):21-31,2009.

13. Itou M, Mitsuyama K, Kawaguchi T, Okabe Y, Suga H, Masuda J, Yamasaki H, Kuwaki K, Taniguchi E, Harada M, Tsuruta O, Sata M.
Leukocytapheresis therapy improved cholestasis in a patient suffering from primary sclerosing cholangitis with ulcerative colitis.
Case Rep Gastroenterol 3(1):77-83,2009.

14. Kume K, Yoshikawa I.
Mucosal bridge due to reflux esophagitis.
Gastroenterology Insights 1(e4):14,2009.

15. Kume K, Yamasaki M, Narita R, Yoshikawa I.
A case of Brunner's gland hyperplasia with features of duodenal cancer.
Gastroenterology Insights 1(e8):24-25,2009.

1. Harada M, Hanada S, Toivola DM, Ghori N, Omary MB.
Autophagy activfation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.
Hepatology 47(6):2026-2035, 2008.

2. Otsuki M, Chung JB, Okazaki K, Kim MH, Kamisawa T, kawa S, Park SW, Shimosegawa T, Lee K, Ito T, Nishimori I, Notohara K, Naruse S, Ko SB, Kihara Y, and the research committee of intractable pancreatic diseases provided by the ministry of health, labour and welfare of Japan and the Korea society of pancreatobiliary diseases.
Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on autoimmune pancreatitis.
Journal of Gastroenterology 43(6):403-408, 2008.

3. Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Kaku M, Watanabe S, Miyamoto T, Otsuki M.
Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models.
GUT 57(6):788-798, 2008.

4. Harada M, Strnad P, Toivola DM, Omary MB.
Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.
Experimental Cell Research 314(8):1753-1764, 2008.

5. Abe S, Narita R, Matsuhashi T, Oto T, Tabaru A, Otsuki M.
Increased soluble IL-2 receptor levels during interferon and ribavirin treatment are associated with a good response in genotype 2a/2b patients with chronic hepatitis C.
European Journal of Gastroenterology and Hepatology 20(5):373-378, 2008.

6. Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB.
Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.
The American Journal of Pathology 172(4):882-892, 2008.

7. Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary MB.
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the CCl4 and thioacetamide models.
Gastroenterology(4):1169-1179, 2008.

8. Kume K, Yamasaki M, Tashiro M, Santo N, Syukuwa K, Maekawa S, Aridome G, Matsuoka H, Murase T, Yoshikawa I, Otsuki M.
Endoscopic mucosal resection for early gastric cancer: comparison of two modifications of the cap method.
Endoscopy 40(4):280-283, 2008.

9. Aida K, Yoshikawa H, Mochizuki C, Mori A, Muto S, Fukuda T, Otsuki M.
Clinicopathological features of gastric cancer detected by endoscopy as part of annual health checkup.
Journal of Gastroenterology and Hepatology 23(4):632-637, 2008.

10. Honda K, Kume K, Yamasaki M, Yoshikawa I, Otsuki M.
Pancreatico-gastric fistulas due to intraductal papillary mucinous neoplasm (IPMN).
Internal Medicine 47(6):557-558, 2008.

11. Kumemura H, Harada M, Yanagimoto C, Koga H, Kawaguchi T, Hanada S, Taniguchi E, Ueno T, Sata M.
Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells.
Biochemical and Biophysical Research Communications 367(1):33-40, 2008.

12. Tai M, Ichii O, Watanabe T, Ejiri Y, Otsuki M.
Transection of metal stents using argon plasma coagulation.
Digestive Endoscopy 20(1):29-32, 2008.

13. Maeyama M, Koga H, Selvendiran K, Yanagimoto C, Hanada S, Taniguchi E, Kawaguchi T, Harada M, Ueno T, Sata M.
Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition.
Cancer 113(10):2823-2831,2008