抄読会紹介文献
呼吸病態学研究室と合同で行っている抄読会での紹介論文のリスト
2026年度
Short- and long-term effects of early-life exposure to PFOS or its alternative PFBS on pulmonary development, Ecotoxicology and Environmental Safety, 315 (2026) 120067. https://doi.org/10.1016/j.ecoenv.2026.120067（20260430西田）
（20260601和泉）
（20260707森元）
（20260901東）
（202610友永）
（202611西田）
（202612Aku）
2025年度
新型コロナウイルス感染症の感染予防の解説について（レヴュー執筆のための論文をまとめて紹介）. （20250407森本(泰)）
Tissue accumulation of microplastics and potential health risks in human, Sci Total Environ., Volume 915, 10 March 2024, 170004. https://doi.org/10.1016/j.scitotenv.2024.170004（20250512友永）
Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma, J Allergy Clin Immunol, 2024; 154: 209-21. https://doi.org/10.1016/j.jaci.2024.02.022（20250623西田）
Integrated bioinformatics analysis for the identification of idiopathic pulmonary fibrosis-related genes and potential therapeutic drugs, BMC Pulmonary Medicine volume 23, Article number: 373 (2023). https://doi.org/10.1186/s12890-023-02678-z（20250714森本(俊)）
The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury, Scientific Reports volume 15, Article number: 22990 (2025). https://doi.org/10.1038/s41598-025-06411-0（20250901中村）
N-Acetyl-L-Cysteine modulates indium-tin oxide nanoparticles-caused interstitial lung diseases in male rats through oxidative stress-activated apoptosis and autophagy, Ecotoxicol Environ Saf, 302:118716 (2025). https://doi.org/10.1016/j.ecoenv.2025.118716（20251006森元）
Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival, Scientific Reports, volume 15, Article number: 34762 (2025). https://doi.org/10.1038/s41598-025-18567-w（20251117和泉）
Estimation of dust concentration by a novel machine vision system, Scientific Reports, volume 12, Article number: 13692 (2022). https://doi.org/10.1038/s41598-022-18036-8（20251201東(秀)）
Associating Genes and Protein Complexes with Disease via Network Propagation, PLoS Comput Biol, 6(1): e1000641. (2010). https://doi.org/10.1371/journal.pcbi.1000641（20260107森本(泰)）
Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study, Particle and Fibre Toxicology, Volume 19, article number 50, (2022). https://doi.org/10.1186/s12989-022-00487-6（20260202友永）
Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports volume 13, Article number: 1225 (2023). https://doi.org/10.1038/s41598-023-28536-w（20260309森本(俊)）
2024年度
Mechanism of miR-204-5p in exosomes derived from bronchoalveolar lavage fluid on the progression of pulmonary fibrosis via AP1S2, Ann Transl Med 2021;9(13):1068. https://doi.org/10.21037/atm-20-8033（20240401森本(俊)）
Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture, Scientific Reports volume 14, Article number: 240 (2024). https://doi.org/10.1038/s41598-023-50618-y（20240513和泉）
Development and performance evaluation of an intelligent air purifier/humidifier using fuzzy logic controller, International Journal of Low-Carbon Technologies, Volume 18, 2023, Pages 82-94. https://doi.org/10.1093/ijlct/ctad004（20240617東(秀)）
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events, The New England Journal of Medicine, 390, 900-10, 2024. https://doi.org/10.1056/NEJMoa2309822（20240701友永）
A network-based trans-omics approach for predicting synergistic drug combinations, Communications Medicine volume 4, Article number: 154 (2024). https://doi.org/10.1038/s43856-024-00571-2（20240729森本）
Polylactic acid nanoplastics (PLA-NPLs) induce adverse effects on an in vitro model of the human lung epithelium: The Calu-3 air-liquid interface (ALI) barrier, Journal of Hazardous Materials, Volume 475(15), 2024, 134900; https://doi.org/10.1016/j.jhazmat.2024.134900（20240902西田）
Nanoplastic Size and Surface Chemistry Dictate Decoration by Human Saliva Proteins, ACS Applied Materials & Interfaces, Vol 16(20), 2024, 25977-25993; https://doi.org/10.1021/acsami.4c00014（20241007佐藤）
Age-Dependent Chronic Lung Injury and Pulmonary Fibrosis following Single Exposure to Hydrochloric Acid, Int. J. Mol. Sci. 2021, 22(16), 8833; https://doi.org/10.3390/ijms22168833 （20241101中村）
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation, Toxicology Letters, 2024, 401, 55-70; https://doi.org/10.1016/j.toxlet.2024.08.013 （20241209東(泰)）
Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells, Biochemical and Biophysical Research Communications, 2003, 302(4), 860-864; https://doi.org/10.1016/S0006-291X(03)00224-9.
Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats, Preventive Medicine, 2012, 54(1), S79-S82; https://doi.org/10.1016/j.ypmed.2011.12.006.
Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway, Human & Experimental Toxicology, 2023, 42, 1-11; https://doi.org/10.1177/09603271231178015. （20250117和泉）
Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis, Journal of Translational Medicine, 21, Article number: 640 (2023); https://doi.org/10.1186/s12967-023-04279-0.（20250203森本(俊)）
Aerosol exposure at air-liquid-interface (AE-ALI) in vitro toxicity system characterization: Particle deposition and the importance of air control responses, Toxicology in Vitro 100 (2024) 105889; https://doi.org/10.1016/j.tiv.2024.105889.（20250303東(秀)）
2023年度
Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin, Redox Biology, 47, 2021, 102174; https://doi.org/10.1016/j.redox.2021.102174（20230517和泉）
New Respirator Fit Test Panels Representing the Current U.S. Civilian Work Force, J Occup Env Hygie, (2007) 4: 647-659; https://doi.org/10.1080/15459620701497538, Fit Assessment of N95 Filtering-Facepiece Respirators in the U.S. Centers for Disease Control and Prevention Strategic National Stockpile, J Int Soc Respir Prot. 2015 ; 32(2): 50-64; https://pubmed.ncbi.nlm.nih.gov/26877587/（20230609東(秀)）
Respiratory disease in workers handling cross-linked water-soluble acrylic acid polymer, PloS One, 2023; Vol.18(4), pp.e0284837; https://doi.org/10.1371/journal.pone.0284837（20230705森本）
Personalised 3D printed respirators for healthcare workers during the COVID-19 pandemic, Front. Med. Technol., Volume 4 (2022); https://doi.org/10.3389/fmedt.2022.963541（20230801大藪）
Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage, Particle and Fibre Toxicology, 20, 2 (2023); https://doi.org/10.1186/s12989-022-00512-8（20230908友永）
Polyhexamethylene guanidine phosphate-induced necrosis may be linked to pulmonary fibrosis, Toxicology Letters, 362, 1-16 (2022); https://doi.org/10.1016/j.toxlet.2022.03.009（20231101西田）
Differences in the characteristics and pulmonary toxicity of nano- and micron-sized respirable coal dust, Respiratory Research, 23, 197 (2022); https://doi.org/10.1186/s12931-022-02120-8（20231206川合）
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats, Particle and Fibre Toxicology, 20, 16 (2023); https://doi.org/10.1186/s12989-023-00525-x（20240131佐藤）
Particulate matter-mediated oxidative stress induces airway inflammation and pulmonary dysfunction through TXNIP/NF-κB and modulation of the SIRT1-mediated p53 and TGF-β/Smad3 pathways in mice, Food and Chemical Toxicology, 183, 114201 (2024); https://doi.org/10.1016/j.fct.2023.114201（20240315東(泰)）
2022年度
Predicting first-order evaporation rate constant alpha (α) from small spills of organic solvents in a controlled environment, Journal of Occupational and Environmental Hygiene, 2022, VOL.19, NO.4, 210-222. https://doi.org/10.1080/15459624.2022.2040736（20220414東(秀)）
Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats, Particle and Fibre Toxicology, 19:27 (2022). https://doi.org/10.1186/s12989-022-00468-9（20220425森本）
Evaluation of N95 respirators, modified snorkel masks and low-cost powered air-purifying respirators: a prospective observational cohort study in healthcare workers, Anaesthesia, 76(5):617-622 (2021). https://doi.org/10.1111/anae.15392（20220513大藪）
Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology, Journal of Hazardous Materials, 416, 126069 (2021). https://doi.org/10.1016/j.jhazmat.2021.126069（20220601友永）
Naringin suppressed airway inflammation and ameliorated pulmonary endothelial hyperpermeability by upregulating Aquaporin1 in lipopolysaccharide/cigarette smoke-induced mice, Biomedicine & Pharmacotherapy, 150, 113035 (2022). https://doi.org/10.1016/j.biopha.2022.113035（20220711東(泰)）
N-acetylcysteine Can Induce Massive Oxidative Stress, Resulting in Cell Death with Apoptotic Features in Human Leukemia Cells, Int. J. Mol. Sci. 2021, 22(23), 12635; https://doi.org/10.3390/ijms222312635（20220729和泉）
Probable airborne transmission of SARS-CoV-2 in a poorly ventilated restaurant, Building and Environment, 2021, 196, 107788. https://doi.org/10.1016/j.buildenv.2021.107788（20220905東(秀)）
Efect of metformin treatment and its time of administration on joint capsular fbrosis induced by mouse knee immobilization, Scientific Reports, 11:17978 (2021). https://doi.org/10.1038/s41598-021-97445-7（20221021森本）
Carbon dioxide increases with face masks but remains below short-term NIOSH limits, BMC Infectious Diseases, 21, 354 (2021). https://doi.org/10.1186/s12879-021-06056-0（20221111大藪）
A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis, Pharmaceutical Biology, 2021, 59(1), 1014-1023; https://doi.org/10.1080/13880209.2021.1950192（20221121友永）
Cytotoxicity and Genotoxicity of Polystyrene Micro- and Nanoplastics with Different Size and Surface Modification in A549 Cells, International Journal of Nanomedicine, 2022, 17:4509-4523. https://doi.org/10.2147/IJN.S381776（20221205川合）
A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae, Sci. Transl. Med. 14, eabo5795 (2022). https://doi.org/10.1126/scitranslmed.abo5795（20221223西田）
Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis, Ann. Transl. Med. 10(10), 566 (2022). https://doi.org/10.21037/atm-22-1397（20230206東(泰)）
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis, Nature Communications,10, 2987 (2019). https://doi.org/10.1038/s41467-019-10839-0（20230324森本(俊)）
2021年度
Exposure of normal and chronic bronchitis-like mucosa models to aerosolized carbon nanoparticles: comparison of pro-inflammatory oxidative stress and tissue injury/repair responses, Nanotoxicology, Volume 13, Issue 10 2019 Pages 1362-1379. https://doi.org/10.1080/17435390.2019.1655600 （20210409森本）
Lung tissue extracellular matrix-derived hydrogels protect against radiation-induced lung injury by suppressing epithelial-mesenchymal transition, Cell Physiol. 2020 Mar;235(3):2377-2388. doi:10.1002/jcp.29143. （20210422大藪）
Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412, Chemosphere, Volume 262, 2021, 128330. https://doi.org/10.1016/j.chemosphere.2020.128330（20210512友永）
Periostin plays a critical role in the cell cycle in lung fibroblasts, Respiratory Research volume 21, Article number: 38 (2020). https://doi.org/10.1186/s12931-020-1299-0 （20210603和泉）
Rapid and low-cost sampling for detection of airborne SARS-CoV-2 in dehumidifier condensate, Biotechnology and Bioengineering, Volume118, Issue8 August 2021 Pages 3029-30361. https://doi.org/10.1002/bit.27812 （20210624東(秀)）
Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats, Toxicology. 2021 Jan 30;448:152647. doi:10.1016/j.tox.2020.152647. （20210708森本）
Aerosol characterization and pulmonary responses in rats after short-term inhalation of fumes generated during resistance spot welding of galvanized steel, Toxicol Rep., 2017 Feb 22;4:123-133. doi: 10.1016/j.toxrep.2017.02.004. （20210910大藪）
Diesel Exhaust Particulates Induce Neutrophilic Lung Inflammation by Modulating Endoplasmic Reticulum Stress-Mediated CXCL1/KC Expression in Alveolar Macrophages, Molecules, 25(24), 2020, 6046. https://doi.org/10.3390/molecules25246046（20210927友永）
Protection of BNT162b2 vaccine booster against Covid-19 in Israel, The New England Journal of Medicine, 2021; 385:1393-1400, May 2021. DOI: 10.1056/NEJMoa2114255 （20211027東(泰)）
MPO promoter polymorphism rs2333227 enhances malignant phenotypes of colorectal cancer by altering the binding affinity of AP-2α, Cancer Research 2018 May 15; 78(10): 2760-2769. DOI: 10.1158/0008-5472.CAN-17-2538 （20211111和泉）
Thermo-fluid Dynamics Analysis and Air Quality for Different Ventilation Patterns in An Operating Theatre, International Journal of Heat and Technology Vol.33 (2015), No.4, pp.25-32. DOI: http://dx.doi.org/10.18280/ijht.330404（20211130東(秀)）
An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition, Cancer Letter 2014 Aug 28;351(1):72-80. DOI: 10.1016/j.canlet.2014.05.006 （20211223森本）
Enhancement of peripheral seal of medical face masks using a 3-dimensional-printed custom frame, The Journal of the American Dental Association Volume 152, Issue 7, July 2021, Pages 542-550. https://doi.org/10.1016/j.adaj.2021.03.011 （20220114大藪）
In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT, Particle and Fibre Toxicology 18, Article number: 25 (2021). https://doi.org/10.1186/s12989-021-00413-2 （20220204友永）
FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis, Clinical and Experimental Immunology, 2021;203(3):433-447. https://doi.org/10.1111/cei.13555 （20220310和泉）
Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in rats via AMPK/SIRT1/NF-κβ, Clin Exp Pharmacol Physiol. 2020 Dec;47(12):1943-1952. https://doi.org/10.1111/1440-1681.13378 （20220330東(泰)）
2020年度
Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo, Nanotoxicology. 2020 Aug;14(6):807-826. doi:10.1080/17435390.2020.1764123. （20200909森本）
Ultrafine particles in scanning sprays: a standardized examination of five powders used for dental reconstruction, Journal of Occupational Medicine and Toxicology, volume 15, Article number: 20 (2020) https://doi.org/10.1186/s12995-020-00271-2 （20200924大藪）
Quantitative Structure-Activity Relationship Models for Predicting Inflammatory Potential of Metal Oxide Nanoparticles, Environ Health Perspect. 2020 Jun;128(6):67010. doi:10.1289/EHP6508. （20201002友永）
The early onset and persistent worsening pulmonary alveolar proteinosis in rats by indium oxide nanoparticles, Nanotoxicology. 2020 May;14(4):468-478. doi:10.1080/17435390.2019.1694184. （20201023友永）
Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets, JCI Insight. 2019;4(5):e126556. https://doi.org/10.1172/jci.insight.126556.（20201106和泉）
Potential impact of a ventilation intervention for influenza in the context of a dense indoor contact network in Hong Kong, Science of The Total Environment, Volumes 569-570, 2016, Pages 373-381 https://doi.org/10.1016/j.scitotenv.2016.06.179 （20201203東）
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy, Particle and Fibre Toxicology volume 17, Article number: 55 (2020) https://doi.org/10.1186/s12989-020-00385-9 （20201217森本）
Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults, Particle and Fibre Toxicology volume 17, Article number: 58 (2020) https://doi.org/10.1186/s12989-020-00389-5 （20210122大藪）
Human Consumption of Microplastics, Environ. Sci. Technol. 2019, 53, 12, 7068-7074 https://doi.org/10.1021/acs.est.9b01517（20210205友永）
Electrostatic fine particles emitted from laser printers as potential vectors for airborne transmission of COVID-19, Environ Chem Lett. 2020 19(1): 1-8. doi:10.1007/s10311-020-01069-8 （20210224西田）
Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots, Nanomaterials (Basel). 2021 Jan 13;11(1):180. doi:10.3390/nano11010180. （20210311和泉）
Aerosol Release by Healthy People during Speaking: Possible Contribution to the Transmission of SARS-CoV-2, Int J Environ Res Public Health. 2020 ; 17(23): 9088. doi:10.3390/ijerph17239088 （20210325東）
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文 責: 労働衛生工学
更新日: 2026年04月30日
