腎臓内科-研究内容-

研究内容

1. 概略

日本人の約1,330万人(国民の約8人に1人)は慢性腎臓病をかかえているという、驚くべき調査結果が最近明らかになりました。慢性腎臓病は単に透析予備群となるだけではなく、心血管疾患の発症や死亡にもつながる、大変恐ろしい国民病です。私たちは最先端の分子生物学の技術を臨床応用することで、これら慢性腎臓病の進展機序の解明や治療法の開発を行い、少しでも腎不全や透析となる患者様を減少させるよう日々研究を行っています。

2. 研究テーマ

1)慢性腎臓病

IgA腎症などの慢性腎炎の原因究明、診断法、治療法の確立。腎生検の施行と診断。合併症の診断、治療。多発性嚢胞腎や髄質嚢胞性腎疾患などの遺伝性腎疾患の診断と治療。

2)血液透析、腹膜透析

透析療法の改良による安全な施行。在宅透析療法としての腹膜透析の普及。透析患者の合併症の診断、治療。

3. 研究業績

最新の主な業績(英文論文のみ抜粋)
医局便りはこちら。

  • Miyamoto T, Nishino T, Nakata T, Sato Y, Komatsu H, Uramatsu T, Ishimatsu N, Ishida K, Serino R, Otsuji Y, Miyazaki M, Tomo T, Tamura M, Fujimoto S: Impact of tonsillectomy combined with steroid pulse therapy on immunoglobulin A nephropathy depending on histological classification: a multicenter study. Clin Exp Nephrol. 2015 [Epub ahead of print]
  • Komatsu H, Sato Y, Miyamoto T, Tamura M, Nakata T, Tomo T, Nishino T, Miyazaki M, Fujimoto S: Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria. Clin Exp Nephrol. 2015 [Epub ahead of print]
  • Nakayama M, Ishida M, Ogihara M, Hanaoka K, Tamura M, Kanai H, Tonozuka Y, Marshall MR: Social functioning and socioeconomic changes after introduction of regular dialysis treatment and impact of dialysis modality: a multi-center survey of Japanese patients. Nephrology (Carlton). 2015 [Epub ahead of print]
  • Kuma A, Tamura M, Ishimatsu N, Miyamoto T, Serino R, Ishimori S, Morisada N, Iijima K, Yamada S, Takeuchi M, Abe H, Otsuji Y: A novel UMOD gene mutation associated with uromodulin-associated kidney disease in a young woman with moderate kidney dysfunction. Intern Med. 54: 631-635, 2015
  • Kashiyama K, Sonoda S, Muraoka Y, Suzuki Y, Kamezaki F, Tsuda Y, Araki M, Tamura M, Takeuchi M, Abe H, Okazaki M, Fujino Y, Otsuji Y: Coronary plaque progression of non-culprit lesions after culprit percutaneous coronary intervention in patients with moderate to advanced chronic kidney disease: intravascular ultrasound and integrated backscatter intravascular ultrasound study. Int J Cardiovasc Imaging. 31: 935-945, 2015
  • Tsutsui M, Tanimoto A, Tamura M, Mukae H, Yanagihara N, Shimokawa H, Otsuji Y: Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice. J Pharmacol Sci. 127: 42-52, 2015
  • Wu VC, Kaku K, Takeuchi M, Otani K, Yoshitani H, Tamura M, Abe H, Lin FC, Otsuji Y: Aortic root geometry in patients with aortic stenosis assessed by real-time three-dimensional transesophageal echocardiography. J Am Soc Echocardiogr. 27: 32-41, 2014
  • Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M: Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol. 77: 29-41, 2014
  • Kuma A, Yamada S, Wang KY, Kitamura N, Yamaguchi T, Iwai Y, Izumi H, Tamura M, Otsuji Y, Kohno K: Role of WNT10A-expressing kidney fibroblasts in acute interstitial nephritis. PLoS One. 23; 9(7): e103240, 2014
  • Watabe T, Abe H, Kohno R, Oginosawa Y, Hayashi K, Ohe H, Tamura M, Takeuchi M, Otsuji Y: Atrial pacing site and atrioventricular conduction in patients paced for sinus node disease. J Cardiovasc Electrophysiol. 25: 1224-1231, 2014
  • Wu VC, Kaku K, Takeuchi M, Otani K, Yoshitani H, Tamura M, Abe H, Lin FC, Otsuji Y: Aortic root geometry in patients with aortic stenosis assessed by real-time three-dimensional transesophageal echocardiography. J Am Soc Echocardiogr. 27: 32-41, 2014
  • Oginosawa Y, Abe H, Ohe H, Hayashi K, Kohno R, Watabe T, Takahashi M, Fujino Y, Tamura M, Takeuchi M, Otsuji Y: Pacing and sensing interference by air bubble surrounding the non-extended helix of intact active fixation lead. Circ J. 78: 2862-2866, 2014
  • Muraoka Y, Sonoda S, Kashiyama K, Kamezaki F, Tsuda Y, Araki M, Tamura M, Takeuchi M, Abe H, Okazaki M, Otsuji Y: Coronary arterial remodeling and out-stent plaque change after drug-eluting stent implantation. Circ J. 77: 363-371, 2013
  • Haruki N, Takeuchi M, Yoshitani H, Otani K, Kuwaki H, Iwataki M, Abe H, Tamura M, Okazaki M, Otsuji Y: Immediate amelioration of mechanical pulsus alternans by adaptive servo-ventilation therapy. Heart Lung Circ. 22: 300-302, 2013
  • Kamezaki F, Sonoda S, Nakata S, Muraoka Y, Okazaki M, Tamura M, Abe H, Tekeuchi M, Otsuji Y: Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance. Hypertens Res. 36: 398-402, 2013
  • Kohno R, Abe H, Akamatsu N, Tamura M, Takeuchi M, Otsuji Y, Benditt DG: Subclinical Tonic-Clonic Epileptic Seizure Detected by an Implantable Loop Recorder. Int Heart J. 54: 289-291, 2013
  • Wu VC, Takeuchi M, Kuwaki H, Iwataki M, Nagata Y, Otani K, Haruki N, Yoshitani H, Tamura M, Abe H, Negishi K, Lin FC, Otsuji Y: Prognostic Value of LA Volumes Assessed by Transthoracic 3D Echocardiography: Comparison With 2D Echocardiography. JACC Cardiovasc Imaging. 6: 1025-1035, 2013
  • Wu VC, Takeuchi M, Otani K, Haruki N, Yoshitani H, Tamura M, Abe H, Lin FC, Otsuji Y: Effect of Through-Plane and Twisting Motion on Left Ventricular Strain Calculation: Direct Comparison between Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography. J Am Soc Echocardiogr. 26: 1274-1281, 2013
  • Minamiguchi H, Oginosawa Y, Kohno R, Tamura M, Takeuchi M, Otsuji Y, Abe H: A 2:1 AV Rhythm: An Adverse Effect of a Long AV Delay during DDI Pacing and Its Prevention by the Ventricular Intrinsic Preference Algorithm in DDD Mode. Pacing Clin Electrophysiol. 35: e189-e192, 2012
  • Minamiguchi H, Abe H, Kohno R, Oginosawa Y, Tamura M, Takeuchi M, Nagatomo T, Otsuji Y: Incidence and characteristics of far-field R-wave sensing in low right atrial septum pacing. Circ J.76: 598-606, 2012
  • Iwataki M, Takeuchi M, Otani K, Kuwaki H, Haruki N, Yoshitani H, Tamura M, Abe H, Otsuji Y: aMeasurement of Left Atrial Volume from Transthoracic Three-Dimensional Echocardiographic Datasets Using the Biplane Simpson's Technique.J Am Soc Echocardiogr. 25: 1319-1326. 2012
  • Otani K, Takeuchi M, Kaku K, Haruki N, Yoshitani H, Eto M, Tamura M, Okazaki M, Abe H, Fujino Y, Nishimura Y, Levine RA, Otsuji Y: Evidence of a vicious cycle in mitral regurgitation with prolapse: secondary tethering attributed to primary prolapse demonstrated by three-dimensional echocardiography exacerbates regurgitation. Circulation. 126 (11 Suppl 1): S214-21, 2012
  • Kamezaki F, Sonoda S, Nakata S, Kashiyama K, Muraoka Y, Okazaki M, Tamura M, Abe H, Takeuchi M, Otsuji Y: Proposed cutoff level of waist circumference in Japanese men: evaluation by homeostasis model assessment of insulin resistance levels. Intern Med. 51: 2119-2124, 2012
  • Nakai H, Kaku K, Takeuchi M, Otani K, Yoshitani H, Haruki N, Tamura M, Okazaki M, Abe H, Tsutsumi A, Levine RA, Otsuji Y: Different influences of left ventricular remodeling on anterior and posterior mitral leaflet tethering. Circ J. 76: 2481-2487, 2012
  • Matsumoto M, Tamura M, Miyamoto T, Furuno Y, Kabashima N, Serino R, Shibata T, Kanegae K, Takeuchi M, Abe H, Okazaki M, Otsuji Y: Impacts of icodextrin on integrin-mediated wound healing of peritoneal mesothelial cells. Life Sci. 90: 917-923, 2012
  • Hayashi M, Takamatsu I, Kanno Y, Yoshida T, Abe T, Sato Y; for the Japanese Calciphylaxis Study Group: A casecontrol study of calciphylaxis in Japanese end-stage renal disease patients. Nephrol Dial Transplant. 27: 1580-1584, 2012
  • Kohno R, Abe H, Nagatomo T, Oginosawa Y, Minamiguchi H, Takeuchi M, Tamura M, Okazaki M, Otsuji Y: The reliability and characteristics of atrial tachyarrhythmias detection in dual chamber pacemakers. Circ J. 75(5): 1090-1097, 2011
  • Kohno R, Abe H, Oginosawa Y, Minamiguchi H, Tamura M, Takeuchi M, Nagatomo T, Otsuji Y: Failure of atrial capture during DDIR pacing in a patient with sinus node disease and preserved atrioventricular conduction: What is the mechanism? Pacing Clin Electrophysiol.34: 1301, 2011
  • Haruki N, Takeuchi M, Kaku K, Yoshitani H, Kuwaki H, Tamura M, Abe H, Okazaki M, Tsutsumi A, Otsuji Y: Comparison of acute and chronic impact of adaptive servo-ventilation on left chamber geometry and function in patients with chronic heart failure. Eur J Heart Fail. 13: 1140-1146, 2011
  • Kamezaki F, Sonoda S, Nakata S, Okazaki M, Tamura M, Abe H, Takeuchi M, Otsuji Y: Elevated depressive symptoms are associated with hypertriglyceridemia in Japanese male workers. Intern Med. 50: 2485-2490, 2011
  • Miyamoto T, Rashid Qureshi A, Yamamoto T, Nakashima A, Lindholm B, Stenvinkel P, Alvestrand A, Axelsson J: Postprandial metabolic response to a fat- and carbohydrate-rich meal in patients with chronic kidney disease. Nephrol Dial Transplant. 26: 2231-2237, 2011
  • Miyamoto T, Carrero JJ, Qureshi AR, Anderstam B, Heimburger O, Barany P, Lindholm B, Stenvinkel P. Circulating follistatin in patients with chronic kidney disease: implications for muscle strength, bone mineral density, inflammation, and survival. Clin J Am Soc Nephrol. 6: 1001-1008, 2011
  • Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M: Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: involvement of bone marrow-derived cells. Nitric oxide. 25: 350-359, 2011
  • Kohno R, Abe H, Akamatsu N, Oginosawa Y, Tamura M, Takeuchi M, Otsuji Y. Syncope and ictal asystole caused by temporal lobe epilepsy. Circ J. 75: 2508-2510, 2011
  • Kuwaki H, Takeuchi M, Kaku K, Haruki N, Yoshitani H, Tamura M, Okazaki M, Abe H, Otsuji Y. Thrombus attached to the left atrial septal pouch assessed on 3-dimensional transesophageal echocardiography. Circ J. 75: 2280-2281, 2011
  • Nakashima A, Carrero JJ, Qureshi AR, Miyamoto T, Anderstam B, Barany P, Heimburger O, Stenvinkel P, Lindholm B: Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients. Clin J Am Soc Nephrol. 5: 2213-2219, 2010
  • Tokunaga M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Fujimoto Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y, Tamura M: Renoprotective effects of telmisartan in patients with advanced chronic kidney disease. Clin Nephrol. 73: 139-146, 2010
  • Miyamoto T, Tamura M, Kabashima N, Serino R, Shibata T, Furuno Y, Miyazaki M, Baba R, Sato N, Doi Y, Okazaki M, Otsuji Y: An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. Nephrol Dial Transplant. 25: 1109-1119, 2010
  • Miyazaki M, Tamura M, Kabashima N, Serino R, Shibata T, Miyamoto T, Furuno Y, Nishio T, Ohara J, Sakurai T, Otsuji Y: Minimal change nephrotic syndrome in a patient with strongyloidiasis. Clin Exp Nephrol. 14: 367-371, 2010
  • Otani K, Takeuchi M, Kaku K, Haruki N, Yoshitani H, Tamura M, Abe H, Okazaki M, Ota T, Lang RM, Otsuji Y: Impact of diastolic dysfunction grade on left atrial mechanics assessed by two-dimensional speckle tracking echocardiography. J Am Soc Echocardiogr. 23: 961-967, 2010
  • Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M: Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo. J Pharmacol Sci. 114: 379-389, 2010
  • Haruki N, Takeuchi M, Kaku K, Yoshitani H, Tamura M, Abe H, Okazaki M, Ota T, Otsuji Y: Prevalence and clinical implication of complex atherosclerotic plaque in the descending thoracic aorta of Japanese patients assessed by transesophageal echocardiography. Circ J. 74: 2627-2632, 2010
  • Olauson H, Qureshi AR, Miyamoto T, Barany P, Heimburger O, Lindholm B, Stenvinkel P, Larsson TE: Relation between serum fibroblast growth factor-23 level and mortality in incident dialysis patients: are gender and cardiovascular disease confounding the relationship? Nephrol Dial Transplant. 25: 3033-3038, 2010
  • Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y: Hepatic angiosarcoma - a rare liver tumor in a hemodialysis patient. Clin Nephrol. 71: 590-592, 2009
  • Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Fujimatsu S, Muta T, Takeuchi M, Abe H, Okazaki M, Otsuji Y: A case report of steroid-resistant ANCA-related vasculitis successfully treated by mizoribine in a hemodialysis patient. Ther Aphre Dial. 13: 77-79, 2009
  • Nagatomo T, Abe H, Kohno R, Toyoshima T, Fujimoto H, Kondo S, Kabashima N, Takeuchi M, Tamura M, Okazaki M, Otsuji Y: Electromagnetic Interference with a bipolar pacemaker by an induction heating (IH) rice cooker. Int Heart J. 50: 133-137, 2009
  • Shibata T, Tamura M, Kabashima N, Serino R, Tokunaga M, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y: Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. Life Sci. 84: 725-731, 2009
  • Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y: Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. Br J Pharmacol. 153: 439-447, 2008.
  • Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y: Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient. Clin Nephrol. 69: 393-394, 2008
  • Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Takeuchi M, Abe H, Okazaki M, Otsuji Y: Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient. Clin Nephrol. 70: 445-446, 2008
  • Koide S, Okazaki M, Tamura M, Ozumi K, Takatsu H, Kamezaki F, Tanimoto A, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y: PTEN reduces cuff-induced neointima formation and proinflammatory cytokines. Am J Physiol Heart Circ Physiol. 292: H2824-2831, 2007
  • Matsumoto M, Kabashima N, Serino R, Tokunaga M, Oikawa S, Shibata T, Otsuji Y, Tamura M: Cerebrotendinous xanthomatosis with minimal change nephrotic syndrome. Nippon Naika Gakkai Zasshi. 96: 150-152, 2007
  • Tamura M, Kabashima N, Serino R, Tokunaga M, Shibata T, Miyamoto T, Miyazaki M, Furuno Y, Otsuji Y: Effects of icodextrin on the integrin-mediated wound healing of peritoneal mesothelial cells. Peritoneal Dial Int. 26 (Supplement 2): S21, 2006
  • Matsuo H, Tamura M, Kabashima N, Serino R, Tokunaga M, Shibata T, Matsumoto M, Aijima M, Oikawa S, Anai H, Nakashima Y: Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kB in peritoneal mesothelial cells. Kidney Int. 69: 736-746, 2006.
  • Yamanaka A, Tasaki H, Suzuki Y, Tanaka S, Yamashita K, Tamura M, Abe H, Otsuji Y: Bosentan improved syncope in a hemodialysis patient with pulmonary hypertension and mild aortic stenosis. Int Heart J. 47: 911-917, 2006
  • Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, Suda O, Ueno S, Toyohira Y, Nakashima Y, Yanagihara N: Vascular neuronal nitric oxide synthase expression is upregulated in response to platelet-derived growth factor through the MEK/ERK pathway. Arterioscl Thromb Vas Biol. 25: 2502-2508, 2005. 
  • Kanegae K, Tamura M, Kabashima N, Serino R, Tokunaga M, Oikawa S, Nakashima Y: Synergistic induction of monocyte chemoattractant protein-1 by integrins and platelet-derived growth factor via focal adhesion kinase in mesangial cells. Nephrol Dial Transplant. 20: 2080-2088, 2005.
  • Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K: Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24: 325-335, 2005.
  • Tamura M, Anai H, Kanegae K, Kabashima N, Serino R, Tokunaga M, Nakashima Y: Synergistic induction of monocyte chemoattractant protein-1 by integrins and platelet-derived growth factor. Nephrology. 10: 266-267, 2005
  • Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M: Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med. 10: 1067-1073, 2004.
  • Oikawa S, Osajima A, Tamura M, Murata K, Yasuda H, Anai H, Kabashima N, Matsushima Y, Nakamoto M, Nakashima Y: Development of proximal calciphylaxis with penile involvement after parathyroidectomy in a patient on hemodialysis. Internal Med. 43: 63-68, 2004
  • Hirakawa N, Tasaki H, Tanaka S, Yamashita K, Okazaki M, Nakashima Y, Kabashima N, Tamura M: Infective tricuspid valve endocarditis due to abscess of an endogenous arteriovenus fistura in a chronic hemodialysis patient. J UOEH. 26: 451-460, 2004
  • Tamura M, Osajima A, Nakayamada S, Anai H, Kabashima N, Kanegae K, Ota T, Tanaka Y, Nakashima Y: High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells. Kidney Int. 63: 722-731, 2003.
  • Takino T, Tamura M, Miyamori H, Araki M, Matsumoto K, Sato H, Yamada KM: Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. J Cell Sci. 116: 3145-3155, 2003.
  • Watanabe Y, Tamura M, Osajima A, Anai H, Kabashima N, Serino R, Nakashima Y: Integrins induce expression of monocyte chemoattractant protein-1 via focal adhesion kinase in mesangial cells. Kidney Int. 64: 431-440, 2003.
  • Nakayamada S, Okada Y, Saito K, Tamura M, Tanaka Y: b1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappa B ligand on osteoblasts and osteoclast maturation. J Biol Chem. 278: 45368-45374, 2003.
  • Tamura K, Okazaki M, Tamura M, Isozumi K, Tasaki H, Nakashima Y: Urotensin II-induced activation of extracellular signal-regulated kinase in cultured vascular smooth muscle cells: Involvement of cell adhesion-mediated integrin signaling. Life Sci. 72: 1049-1060, 2003.
  • Nakayamada S, Saito K, Fujii K, Yasuda M, Tamura M, Tanaka Y: b1 integrin-mediated signaling induces ICAM-1 and Fas and Fas-mediated apoptosis of rheumatoid synovial cells. Arthritis Rheum. 48: 1239-1248, 2003.
  • Iwamoto M, Osajima A, Tamura M, Suda T, Ota T, Kanegae K, Watanabe Y, Kabashima N, Anai H, Nakashima Y: Adrenomedullin inhibits pressure-induced mesangial MCP-1 expression through activation of protein kinase A. J Nephrol. 16:673-681, 2003.
  • Suda T, Osajima A, Iwamoto M, Anai H, Tamura M, Kabashima N, Ota T, Watanabe Y, Kanegae K, Okazaki M, Nakashima Y: The mature form of adrenomedullin correlates with brain natriuretic peptide in plasma of chronic hemodialysis patients. Clin Nephrol. 57: 444-451, 2002.
  • Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I: Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension. 39: 233-238, 2002.
  • Ota T, Tamura M, Osajima A, Doi Y, Kudo H, Anai H, Miyazaki M, Nishino T, Nakashima Y: Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive renal failure. J Lab Clin Med. 140: 43-51, 2002.
  • Osajima A, Okazaki M, Tamura M, Anai H, Kabashima N, Suda T, Iwamoto M, Ota T, Watanabe Y, Kanegae K, Nakashima Y: Comparison of plasma levels of mature adrenomedullin and natriuretic peptide as markers of cardiac function in hemodialysis patients with coronary artery disease. Nephron. 92: 832-839, 2002.
  • Tamura M, Osajima A, Nakayamada S, Anai H, Kabashima N, Kanegae K, Ota T, Tanaka Y, Nakashima Y: High glucose inhibits focal adhesion kinase (FAK)-mediated wound healing of peritoneal mesothelial cells. Nephrol Dial Transplant. 17: 300-301, 2002
  • Yasuda M, Tanaka Y, Tamura M, Fujii K, Sugaya M, So T, Takenoyama M, Yasumoto K: Stimulation of β1 integrin down-regualtes ICAM-1 expression and ICAM-1-dependent adhesion of lung cancer cells through focal adhesion kinase. Cancer Res. 61: 2022-2030, 2001.
  • Osajima A, Okazaki M, Kato H, Anai H, Tsuda Y, Segawa K, Tanaka H, Tamura M, Takasugi M, Nakashima Y: Clinical significance of natriuretic peptides and cyclic GMP in hemodialysis patients with coronary artery disease. Am J Nephrol. 21: 112-119, 2001.
  • Suda T, Osajima A, Tamura M, Kato H, Iwamoto M, Ohta T, Kanegae K, Tanaka H, Anai H, Kabashima N, Okazaki M, Nakashima Y: Pressure-induced expression of monocyte chemoattractant protein-1 through activation of MAP kinase. Kidney Int. 60: 1705-1715, 2001.
  • Tamura K, Okazaki M, Tamura M, Kanegae K, Okuda H, Abe H, Nakashima Y: Synergistic interaction of integrin and angiotensin II in activation of extracellular signal-regulated kinase pathways in vascular smooth muscle cells. J Cardiovasc Pharm. 38: S59-S62, 2001.
  • Serino R, Ueta Y, Hanamiya M, Nomura M, Yamamoto Y, Yamaguchi K, Nakashima Y, Yamashita H: Increased levels of hypothalamic neuronal nitric oxide synthase and vasopressin in salt-loaded Dahl rat. Autonomic Neuroscience. 87: 225-235, 2001.
  • Hirano H, Tamura M, Nakano M, Arashidani K, Harada K, Arai A, Hirano T: The envelopment of malignant tumor cells using the fuzzy set chaos theory during histological regulation. Biomedical Soft Computing and Human Sciences. 5: 31-36, 2000
  • Hirano H, Tamura M, Hamada T, Sasaguri Y, Nakano M, Arashidani K, Harada K, Arai A, Hirano T: Gene Expression Programming for Fibrogenesis by Fuzzy Chaos Algorithm Suppressed Metastasized Cancer Cells. Int J Chaos Theory Appli. 5: 61-66, 2000
  • Tamura M, Tanaka H, Yashiro A, Osajima A, Okazaki M, Kudo H, Doi Y, Fujimoto S, Higashi K, Nakashima Y, Hirano H: Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells. J Am Soc Nephrol. 11: 423-433, 2000.
  • Tamura M, Yanagihara N, Tanaka H, Osajima A, Hirano T, Higashi K, Yamada KM, Nakashima Y, Hirano H: Activation of DNA synthesis and AP-1 by profilin, an actin-binding protein, via binding to a cell surface receptor in cultured rat mesangial cells. J Am Soc Nephrol. 11: 1620-1630, 2000.
  • Osajima A, Katoh H, Uezono Y, Suda T, Okazaki M, Oishi Y, Tamura M, Tanaka H, Izumi F, Nakashima Y: Adrenomedullin inhibits transmural pressure induced mesangial cell proliferation through activation of protein kinase A. Nephron. 83: 352-357, 1999
  • Katoh H, Osajima A, Uezono Y, Okazaki M, Tsuda Y, Tanaka H, Oishi Y, Izumi F, Nakashima Y: Involvement of PDGF in pressure-induced mesangial cell proliferation through PKC and tyrosine kinase pathways. Am J Physiol. F105-F112, 1999
  • Serino R, Ueta Y, Hara Y, Nomura M, Yamamoto Y, Shibuya I, Hattori Y, Kitamura K, Kangawa K, Russell JA, Yamashita H: Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology. 140: 2334-2342, 1999
  • Tamura M, Gu J, Takino T, Yamada KM: Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 59: 442-449, 1999.
  • Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R: Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ system. Proc Natl Acad Sci USA. 96: 1563-1568, 1999.
  • Tamura M, Gu J, Danen EHJ, Takino T, Miyamoto S, Yamada KM: PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 274: 20693-20703, 1999.
  • Gu J, Tamura M, Pankov R, Danen EHJ, Takino T, Matsumoto K, Yamada KM: Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol. 146: 389-403, 1999.
  • Tamura M, Gu J, Tran H, Yamada KM: PTEN gene and integrin signaling in cancer. J Natl Cancer Inst. 91: 1820-1828, 1999.
  • Osajima A, Katoh H, Uezono Y, Suda T, Okazaki M, Oishi Y, Tamura M, Tanaka H, Izumi F, Nakashima Y: Adrenomedullin inhibits transmural pressure induced mesangial cell proliferation through activation of protein kinase A. Nephron. 83: 352-357, 1999.
  • Serino R, Ueta Y, Hara Y, Nomura M, Yamamoto Y, Shibuya I, Hattori Y, Kitamura K, Kangawa K, Russell JA, Yamashita H. Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology. 140: 2334-2342, 1999.
  • Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM: Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science. 280: 1614-1617, 1998.
  • Gu J, Tamura M, Yamada KM: Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol. 143: 1375-1383, 1998.
  • Serino R, Ueta Y, Tokunaga M, Hara Y, Nomura M, Kabashima N, Shibuya I, Hattori Y, Yamashita H: Upregulation of hypothalamic nitric oxide synthase gene expression in streptozocin-induced diabetic rats. Diabetologia. 41:640-648, 1998.
  • Kabashima N, Shibuya I, Ibrahim N, Ueta Y, and Yamashita H: Inhibition of spotaneous EPSCs and IPSCs by presynaptic GABAB receptors on rat supratic magnocellular neurons. J Physiol (Lond.) 504: 113-126, 1997
  • Kabashima N, Shibuya I, Ibrahim N, Ueta Y, Yamashita H: Inhibition of spontaneous EPSCs and IPSCs by presynaptic GABAB receptors on rat supraoptic magnocellular neurons. J Physiol. (Lond.) 504: 113-126,1997
  • Tanaka H, Tamura M, Osajima A, Hirano H, Nakashima Y: Cloning of profilin and its enhanced expression in experimental glomerulonephritis. Nephrology. 3: 115-115, 1997
  • A case of myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-positive crescentic glomerulonephritis induced by propylthiouracil (PTU). Kato H, Osajima A, Tanaka H, Serino R, Kabashima N, Tamura M, Segawa K, Anai H, Takasugi M, Nakajima Y. Nippon Jinzo Gakkai Shi.39: 517-22, 1997
  • Tamura M, Tanaka H, Hirano T, Ueta Y, Higashi K, Hirano H. Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis, Biochem Biophys Res Commun. 222: 683-687, 1996.
  • Osajima A, Uezono Y, Tamura M, Kitamura K, Mutoh Y, Ueta Y, Kangawa K, Kawamura M, Eto T, Yamashita H, Izumi F, Takasugi M, Kuroiwa A: Adrenomedullin-sensitive receptors are preferentially expressed in cultured rat mesangial cells. Eur J Pharmacol. 315: 319-325, 1996
  • Hirano H, Hirano T, Hirata K, Tamura M, Yamaura T, Hamada T: Experimental liver fibrosis induced in rats receiving high doses of alcohol and alternating between regular and vitamin-depleted diets. Experientia (Cell Mol Life Sci). 52: 710-715, 1996
  • Tamura M, Tanaka H, Osajima A, Hirano T, Nakashima Y, Hirano H: Involvement of profilin in experimental mesangial proliferative glomerulonephritis. J Am Soc Nephrol. 7: 1766-1766, 1996
  • Hirano H, Hirano T, Nakano M, Hirata K, Tamura M: A novel approach for obtaining a cDNA clone that codes functional protein by applying the fuzzy set cloning theory. Biomedical Fuzzy and Human Sciences. 2: 19-24, 1996
  • Serino R, Osajima A, Hiroshige K, Anai H, Tanaka H, Kabashima N, Tamura M, Segawa K, Takasugi M, Kuroiwa A. Renovascular hypertension associated with antiphospholipid antibodies in a woman with systemic lupus erythematosus. Nippon Jinzo Gakkai Shi. 38: 417-22, 1996
  • Tamura M, Osajima A, Hirano T, Kuroiwa A, Hirano H: Extracellular profilin increases AP-1 DNA binding activity and c-jun expression via protein kinase C in rat mesangial cells. J Am Soc Nephrol. 6: 814-814, 1995
  • Tamura M, Hiroshige K, Osajima A, Soejima M, Takasugi M, Kuroiwa A: A dialysis patient with systemic calciphylaxis exhibiting rapidly progressive visceral ischemia and acral gangrene. Intern Med. 34: 908-912, 1995
  • Tamura M, Hayashi T, Nagatomo H, Yoshii C, Tao Y, Nikaido Y, Nagata N, Kido M. A case of sarcoidosis with advanced cystic and fibrotic changes in a young patient. Nihon Kyobu Shikkan Gakkai Zasshi. 33: 358-362, 1995
[文責:第2内科学講座 穴井 玲央 更新日:2021年3月19日]