Anatomy (Ⅰ)



Department of Anatomy (I), School of Medicine,

University of Occupational and Environmental Health Japan


Welcome to the Department of Anatomy (I) website






Professor: Kagaku AZUMA, MD, Ph.D

Lecturer: Yasuhiro ADACHI, PhD.

Assistant Professor: Haruki HAYASHI, MS.



Available positions:

We are seeking well-qualified graduate students and postdoctoral researchers to participate in our studies. Interested candidates should send cover letter, resume to:

Dr. Kagaku Azuma,

Department of Anatomy, UOEH, School of Medicine,

Iseigaoka 1-1, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, JAPAN


Tel: +81-93-691-7418

Fax: +81-93-691-8544



Research Projects

1. Morphological analysis of the bone remodeling and osteoporosis

2. Active mastication, stress-related disorders, and brain function

3. Computational anatomy and three-dimensional model construction

4. Fatty acid-binding protein (FABP) expression

5. Structure and function of lymphatic tissue



Latest publication list



Azuma K, Zhou Q, Niwa M, Kubo KY.

Association between mastication, the hippocampus, and the HPA axis: a comprehensive review.

Int J Mol Sci 18:1867, 2017


Kondo H, Uchida M, Ichihashi Y, Suzuki A, Hayashi S, Iinuma M, Azuma K, Kubo KY.

Maternal occlusal disharmony during pregnancy induces spatial memory deficits associated with the suppression of hippocampal neurogenesis in adult mouse offspring.

Pediatric Dental J 27:49-55, 2017


Azuma K, Ogura M, Kondo H, Suzuki A, Hayashi S, Iinuma M, Onozuka M, Kubo KY.

Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring.

Int J Med Sci 14:348-355, 2017


Kubo KY, Murabayashi C, Kotachi M, Suzuki A, Mori D, Sato Y, Onozuka M, Azuma K, Iinuma M.

Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice.

Arch Oral Biol 74: 21-27, 2017




Suzuki A, Iinuma M, Hayashi S, Sato Y, Azuma K, Kubo KY.

Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring.

Brain Res 1651:36-43, 2016


Kondo H, Kurahashi M, Mori D, Iinuma M, Tamura Y, Mizutani K, Shimpo K, Sonoda S, Azuma K, Kuno KY.

Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment.

Arch Oral Biol 61:1-7, 2016


Ueda M, Li S, Itoh M, Wang MX, Hayakawa M, Islam S, Tana, Nakagawa K, Chen H, Nakagawa T. Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion.

Biochem Biophys Res Commun 474:259-63, 2016


Miyake H, Mori D, Katayama T, Fujiwara S, Sato Y, Azuma K, Kubo KY.

Novel stress increases hypothalamic-pituitary-adrenal activity in mice with a raised bite.

Arch Oral Biol 68:55-60, 2016



Azuma K, Adachi Y, Hayashi H, Kubo KY.

Chronic Psychological Stress as a Risk Factor of Osteoporosis.

J UOEH 37:245-253, 2015 


Azuma K, Furuzawa M, Fujiwara S, Yamada K, Kubo KY.

Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice.

Int J Med Sci 12:952-957, 2015


Endo S, Nishiyama A, Suyama M, Takemura M, Soda M, Chen H, Tajima K, El-Kabbani O, Bunai Y, Hara A, Matsunaga T, Ikari A.

Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells.

Chem Biol Interact 234:282-289, 2015


Chen H, Senda T, Kubo KY.

The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.

Med Mol Morphol 48:68, 2015


Chen H, Iinuma M, Onozuka M, Kubo KY.

Chewing maintains hippocampus-dependent cognitive function.

Int J Med Sci 12:502-509, 2015


Kubo KY, Iinuma M, Chen H.

Mastication as a stress-coping behavior.

Biomed Res Int 2015:876409, 2015


Kurahashi M, Kondo H, Iinuma M, Tamura Y, Chen H, Kubo K.

Tooth loss early in life accelerateds age-remlated bone deterioration in mice.

Tohoku J Exp Med 235:29-37, 2015


Shibue K, Yamane S, Harada N, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada, Takayanagi R, Inagaki N.

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Am J Physiol Endocrinol Metab 308(7): E583-91, 2015



Chen H, Kubo KY.

Bone three-dimensional microstructural features of the common osteoporotic fracture sites.

World J Orthopedics 5:486-95, 2014


Iinuma M, Kondo H, Kurahashi M, Ohnishi M, Tamura Y, Chen H, Kubo KY.

Relationship between the early toothless condition and hippocampal functional morphology.

Anat Physiol 4:3, 2014


Furuzawa M, Chen H, Fujiwara S, Yamada K, Kubo KY.

Chewing ameliorates chronic mild stress-induced bone loss in senescence- accelerated mouse (SAMP8), a murine model of senile osteoporosis.

Exp Gerontol 55:12-18, 2014


Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Matsumoto M, Chen H, Hida Y, Nakagawa T.

Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.

Biochem Biophys Res Commun 443:1232-8, 2014


Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H.

Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis.

PLoS One 9:e103818, 2014


Kizuka-Shibuya F, Tokuda N, Takagi K, Adachi Y, Lee L, Tamura I, Maekawa R, Tamura H, Suzuki T, Owada Y, Sugino N.

Locally existing endotherial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice.

J Ovarian Res 7: 10, 2014


Miyazaki H, Sawada T, Kiyohira M, Yu Z, Nakamura K, Yasumoto Y, Kagawa Y, Ebrahimi M, Islam A, Sharifi K, Kawamura S, Kodama T, Yamamoto Y, Adachi Y, Tokuda N, Terai S, Sakaida I, Ishikawa T, Owada Y.

Fatty acid binding protein 7 regulates phagocytosis and cytokine production in kupffer cells during liver injury.

Am J Pathol 184: 2505-2515, 2014


Hayashi T, Chen H, Miyamoto K, Zhou X, Hara T, Fujita H.

Computer-aided image analysis for vertebral anatomy on X-ray CT images.

Computational Intelligence in Biomedical Imaging,

Suzuki K ed, Springer: p159-184, 2014