職業性腫瘍学 研究業績

2022年度以降の業績

学術論文

2023年度

• 　　Kawasaki Y, Li Y-S, Ootsuyama Y, Fujisawa K, Omori H, Onoue A, Kubota K, Yoshino T, Nonami Y, Yoshida M, Yamato H, Kawai K. Assessment of exposure and DNA damage from second-hand smoke using potential biomarker in urine: cigarettes and heated tobacco products. J Clin Biochem Nutr. 2023 May;72(3):242-247.
• 　　Fujisawa K. Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases. Int J Mol Sci. 2023 Mar 14;24(6):5561.
• 　　Nagai H, Miwa A, Yoneda K, Fujisawa K, Takami T. Optimizing the Seeding Density of Human Mononuclear Cells to Improve the Purity of Highly Proliferative Mesenchymal Stem Cells. Bioengineering (Basel). 2023 Jan 11;10(1):102.
• 　　Mano Y, Tsukamoto M, Wang K-Y, Nabeshima T, Kosugi K, Tajima T, et al. Li Y-S(17) , Kawai K(18), et al. Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model. J Bone Miner Metab. 2022 Nov;40(6):927-939. doi: 10.1007/s00774-022-01371-1.

2022年度

・Fujii T, Nishikawa J, Fukuda S, Kubota N, Nojima J, Fujisawa K, Ogawa R, Goto A, Hamabe K, Hashimoto S, Wai AP, Iizasa H, Yoshiyama H, Sakai K, Suehiro Y, Yamasaki T, Takami T.

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.

Int J Mol Sci. 2022 Sep 13;23(18):10597. 

・ Fujisawa K, Nishimura Y, Sakuragi A, Duponselle J, Matsumoto T, Yamamoto N, Murata T, Sakaida I, Takami T.

Evaluation of the Effects of Microgravity on Activated Primary Human Hepatic Stellate Cells.

Int J Mol Sci. 2022 Jul 4;23(13):7429. doi: 10.3390/ijms23137429.

PMID: 35806434 

・ Horigome R, Kamimura K, Niwa Y, Ogawa K, Mizuno KI, Fujisawa K, Yamamoto N, Takami T, Sugano T, Sakamaki A, Kamimura H, Takamura M, Terai S.

Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis.

J Clin Med. 2022 Jun 25;11(13):3674. doi: 10.3390/jcm11133674.

PMID: 35806959 

・  Fujisawa K, Takami T, Matsumoto T, Yamamoto N, Yamasaki T, Sakaida I.

An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells.

Cancer Metab. 2022 May 12;10(1):8.

PMID: 35550011 

・  Fujisawa K, Wakazaki M, Matsuzaki A, Matsumoto T, Yamamoto N, Noma T, Takami T.

Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism.

Int J Mol Sci. 2022 Apr 13;23(8):4316. doi: 10.3390/ijms23084316.

PMID: 35457131 

これまでの研究業績 (2021年度まで）

著書

Kasai H, Kawai K. 8-Hydroxyguanine, an Oxidative DNA and RNA Modification.Modified Nucleic Acids in Biology and Medicine. Springer　Cham, Switzerland. 2016 pp.147-185

学術論文

2020年

Li Y-S, Kawasaki Y, Watanabe S, Ootsuyama Y, Kasai H, Kawai K. Diurnal and day-to-day variation of urinary oxidative stress marker 8-hydroxy-2'-deoxyguanosine. J Clin Biochem Nutr. 2020. 印刷中

Watanabe S, Kawasaki Y, Kawai K. Salivary 8-Hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers. J Clin Biochem Nutr. 2020, 66(1):57-61

2019年

Watanabe S, Li Y-S, Kawasaki Y, Kawai K.労働者の生活習慣が生体内酸化ストレスに及ぼす影響. Journal of UOEH. 2019,41(4):431-436

Watanabe S, Kawasaki Y, Kawai K. Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine. Genes and environment. 2019, 41:20

Sun L, Igarashi T, Tetsuka R, Li Y-S, Kawasaki Y, Kawai K, et al. Pilot clinical study of ascorbic acid treatment in cardiac catheterization. Journal of radiation research. 2019, 60(5):573-578

Kasai H, Kawasaki Y, Kawai K. Pyrimidine Ring-Opened Product from Oxidative DNA Damage of 5-Formyl-2'-deoxyuridine. Chemical research in toxicology. 2019, 32(4):737-744

Anan A, Li Y-S, Tsuji M, Nagamatsu Y, Chou S, Toyofuku K, Kawai K. Mental/Physical Stress Levels of Female Nurses' Working Rotational Shifts. 日本職業・災害医学学会誌. 2019, 67(2):167-174

Kawakami R, Kashino I, Kasai H, Kawai K, Li Y-S, et al. Leisure-time physical activity and DNA damage among Japanese workers. PloS one.2019, 14(2):e0212499

2018年

Shimanoe C, Hara M, Nishida Y, Nanri H, Horita M, Yamada Y, Li Y-S, Kasai H, Kawai K, et al. Perceived Stress, Depressive Symptoms, and Oxidative DNA Damage. Psychosomatic medicine　80(1):28-33

Kashino I, Li Y-S, Kawai K, Nanri A, Miki T, Akter S, Kobayashi S, Kasai H, Mizoue T: Dietary non-enzymatic antioxidant capacity and DNA damage in a working population. Nutrition (Burbank, Los Angeles County, Calif.). 2018, 47:63-68

Kawai K, Kasai H, Li Y-S, Kawasaki Y, Watanabe S, et al. Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD. Genes and environment: the official journal of the Japanese Environmental Mutagen Society. 2018, 40:5

Li Y-S, Ootsuyama Y, Kawasaki Y, Morimoto Y, Higashi T, Kawai K. Oxidative DNA damage in the rat lung induced by intratracheal instillation and inhalation of nanoparticles. Journal of clinical biochemistry and nutrition.2018, 62(3):238-241

2017年

Tomonaga T, Izumi H, Yoshiura Y, Myojo T, Oyabu T, Lee B-W, Okada T, Li Y-S, Kawai K, et al. Assessment of Pulmonary Toxicity Induced by Inhaled Toner with External Additives. BioMed research international.　2017:4245309

Kakehashi A, Stefanov VE, Ishii N, Okuno T, Fujii H, Kawai K, et al. Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. International Journal of Molecular Sciences. 2017, 18(2):1-21

Igata R, Katsuki A, Kakeda S, Watanabe K, Igata N, Hori H, Konishi Y, Atake K, Kawasaki Y, et al. PCLO rs2522833-mediated gray matter volume reduction in patients with drug-naive, first-episode major depressive disorder. Translational psychiatry. 2017, 7(5):e1140

川崎 祐也, 渡邉 晋太郎, 藤川 和男, 河井 一明: 職業病予防における遺伝情報の活用　結晶質シリカ暴露による珪肺症の場合. 日本遺伝カウンセリング学会誌. 2017, 38(2):75

Li Y-S, Kawasaki Y, Tomita I, Kawai K. Antioxidant properties of green tea aroma in mice. Journal of clinical biochemistry and nutrition. 2017, 61(1):14-17

Kim M, Na H, Kasai H, Kawai K, Li Y-S, Yang M: Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human. Journal of Cancer Prevention. 2017, 22(3):174-181

葛西 宏, 川崎 祐也, 河井 一明: ビフィズス菌増殖刺激物質1,4-ジヒドロキシ-2-ナフトエ酸の新しい安定な誘導体. 日本癌学会総会記事　76回: 2017, P-2408

Oyabu T, Myojo T, Lee B-W, Okada T, Izumi H, Yoshiura Y, Tomonaga T, Li Y-S, Kawai K, et al. Biopersistence of NiO and TiO₂Nanoparticles Following Intratracheal Instillation and Inhalation. International journal of molecular sciences. 2017, 18(12):1-14

2016年

Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Lee B-W, Okada T, Oyabu T, Myojo T, Kawai K, et al. Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles. Nanotoxicology. 2016, 10(5):607-618

Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Oyabu T, Myojo T, Kawai K, et al. Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation. International journal of molecular sciences. 2016, 17(8):E1241

Hara M, Nishida Y, Shimanoe C, Otsuka Y, Nanri H, Yasukata J, Miyoshi N, Yamada Y, Horita M, Kawai K, Li Y-S, Kasai J, Kasai H, et al. Intensity-specific effect of physical activity on urinary levels of 8-hydroxydeoxyguanosine in middle-aged Japanese. Cancer science. 2016, 107(11):1653-1659

【文責：職業性腫瘍学、更新日：2022年5月10日】