第2生理学 研究業績

原田景太 ・ 医学博士

１　Morimoto S, Harada K, and Ohtsuki I：
　　Roles of troponins in pH dependence of contraction in rabbit fast skeletal and cardiac muscles.
　　J Biochem 126:121-129, 1999

２　Harada K, Takahashi-Yanaga F, Minakami R, Morimoto S, and Ohtsuki I:
　　Functional consequences of the deletion mutation ΔGlu160 in human cardiac troponin T.
　　J Biochem 127: 263-268, 2000

３　Harada K, Arana C, and Potter JD:
　　Magnesium-calcium exchange with the high affinity Ca2+-Mg2+ binding sites of cardiac troponin.
　　J Mol Cell Cardiol 33:2095-2107, 2001

４　Takahashi-Yanaga F, Morimoto S, Harada K, Minakami R, Shiraishi F, Ohta M, Lu QW, Sasaguri T, and Ohtsuki I:
　　Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy.
　　J Mol Cell Cardiol 33:2095-2107, 2001

５　Morimoto S, Lu QW, Harada K, Takahashi-Yanaga F, Minakami R, Ohta M, Sasaguri T, and Ohtsuki I:
　　Ca2+-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.
　　Proc Natl Acad Sci U S A. 99:913-918, 2002

６　Venkatraman G, Harada K, Gomes AV, Kerrick GW, and Potter JD:
　　Different functional properties of troponin T that cause dilated cardiomyopathy.
　　J Biol Chem 278:41670-41676, 2003

７　Lu QW, Morimoto S, Harada K, Du CW, Takahashi-Yanaga F, Sasaguri T, and Ohtsuki I:
　　Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and cause a 　　Ca2+- desensitization.
　　J Mol Cell Cardiol 35:1421-1427, 2003

８　Harada K and Potter JD:
　　Familial hypertrophic cardiomyopathy mutations from different functional region of troponin T result in various effects on the pH- a　　　　      nd Ca2+ sensitivity of cardiac muscle contraction.
　　J Biol Chem 279:14488-14495, 2004

９　Gomes AV, Barnes JA, Harada K, and Potter JD:
　　Role of troponin T in disease. (Review)
　　Mol. Cell Biochem 263:115-129, 2004

10　Harada K and Morimoto S:
　　Inherited cardiomyopathies as a troponin disease. (Review)
　　Jpn J Physiol 54:307-318, 2004

11　Gomes AV, Harada K, and Potter JD:
　　A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca2+-sensitivity,  phos       phorylation kinetics and proteolytic susceptibility of troponin.
　　J Mol Cell Cardiol 39:754-765, 2005

12　Chang AN, Harada K, Ackerman MJ, and Potter JD:
　　Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin.
　　J Biol Chem 280:34343-34349, 2005

13　Harada K, Lin H, Endo Y, Fujishiro N, Sakamoto Y, and Inoue M:
　　Subunit composition and role of Na+,K+-ATPase in ventricular myocytes.
　　J Physiol Sci 56:113-121, 2006

14　Endo Y, Harada K, Fujishiro N, Funahashi H, Shinoda S, Prestwich GD, Mikoshiba K, and Inoue M:
　　Organelles containing inositol triphosphate receptor type 2 in adrenal medullary cells.
　　J Physiol Sci 56:415-423, 2006

15　Inoue M, Harada K, Matsuoka H, Sata T, Warashina A:
　　Inhibition of TASK1-like channels by muscarinic receptor stimulation in rat adrenal medullary cells.
　　J Neurochem 106:1804-1814, 2008

16　Matsuoka H, Harada K, Warashina A, Doi Y, Nakamura J, Inoue M:
　　Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells.
　　J Physiol 586:4825-4842, 2008

17　Matsuoka H, Harada K, Ikeda T, Uetsuki K, Sata T, Warashina A, Inoue M:
　　Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells.
　　Am J Physiol Cell Physiol 296:889-899, 2009

18　Harada K, Matsuoka H, Fujimoto N, Endo Y, Hasegawa Y, Matsuo A, Kikuchi Y, Matsumoto T, Inoue M:
　　Localization of type-2 angiotensin II receptor in adrenal gland.
　　J Histochem Cytochem 58:585-593, 2010

19　Harada K, Matsuoka H, Nakamura J, Fukuda M, and Inoue M:
　　Storage of GABA in chromaffin granules and not in synaptic-like microvesicles in rad adrenal medullary cells.
　　J Neurochem 114:617-626, 2010

20　Inoue M, Harada K, Matsuoka H, Warashina A:
　　Paracrine role of GABA in adrenal chromaffin cells.
　　Cell Mol Neurobiol 30:1217-1224, 2010

21　Ogawa K, Harada K, Endo Y, Sagawa S, and Inoue M:
　　Heterogeneous levels of oxidative phosphorylation enzymes in rat adrenal grands.
　　Acta histochem 113:24-31, 2011

22　Matsuoka H, Harada K, Nakamura J, Fukuda M, Inoue M:
　　Differential distribution of synaptotagmin-1, -4, -7 and -9 in rat adrenal chromaffin cells.
　　Cell Tissue Res 344:41-50, 2011

23　Harada K, Matsuoka H, Sata T, Warashina A, Inoue M:
　　Identification and role of muscarinic receptor subtypes expressed in rat adrenal medullary cells.
　　J Pharmacol Sci 117:253-264, 2011

24　Inoue M, Harada K, Matsuoka H, Nakamura J, Warashina A:
　　Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells.
　　Am Physiol Cell Physiol 303:C635-644, 2012

25　Matsuoka H, Harada K, Nakamura J, Inoue M:
　　Nerve growth factor-induced endocytosis of TWIK-related acid sensitive K+ channels in adrenal medullary cells and PC12 cells.
　　Pflugers Arch 465:1051-1064, 2013

26　Inoue M, Harada K, Nakamura J, Matsuoka H:
　　Regulation of α3--containing GABAA receptors in guinea-pig adrenal medullary chromaffin cells by adrenal steroid.
　　Neuroscience 253:245-255, 2013

27　Harada K, Matsuoka H, Miyata H, Matsui M, Inoue M:
　　Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic 　　deletion.
　　Br J Pharmacol 172:1348-1359, 2015

28　Harada K, Endo Y, Warashina A, Inoue M:
　　Catecholamine secretion by chemical hypoxia in guinea-pig, but not rat, adrenal medullary cells: differences in mitochondria.
　　Neuroscience 301:134-143, 2015

29　Harada K, Matsuoka H, Fujihara H, Ueta Y, Yanagawa Y, Inoue M:
　　GABA signaling and neuroactive steroids in adrenal medullary chromaffin cells. (Review)
　　Front Cell Neurosci 10:100, 2016

30 　Inoue M, Matsuoka H, Harada K:
　　Muscarinic receptors in adrenal chromaffin cells: physiological role and regulation of ion channel. (Review)
　　Pflugers Arch, 2017 470 (1):29-38

31   Harada K, Matsuoka H, Inoue M:
　　Expression and regulation of M-type K+ channel in PC12 cells and rat adrenal medullary cells. 
　　Cell Tissue Res, 2018 372(3):457-468

32   Inoue M, Matsuoka H, Lesage F, Harada K:
　　Lack of p11 expression facilitatesacidity-sensing function of TASK1 channels in mouse adrenal medullary cells.
　　FASEB J, 2019 33(1):455-468

33   Inoue M, Harada K, Matsui M, Matsuoka H: 
　　Differences among muscarinic agonists in M1 receptor-mediated nonselective cation channel activation and TASK1 channel inhibitio  　　n in adrenal medullary cells.
      Eur J Pharmacol, 2019  15:843:104-112

34   Harada K, Matsuoka H, Inoue M:
　　STIM1-dependent membrane insertion of heteromeric TRPC1-TRPC4 channels in response to muscarinic receptor stimulation.
　　J Cell Sci, 2019 31:132(11):jcs227389

35   Matsuoka H, Harada K, Mashima K, Inoue M:
　　Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells.
　　Cell Signal, 2020 65:109434

36   Inoue M, Harada K, Matsuoka H:
　　Mechanisms for pituitary adenylate cyclase-activating polypeptide-induced increase in excitability in guinea-pig and mouse adrenal 　　medullary cells.
　　Eur J Pharmacol, 2020 5:872:172956

37   Inoue M, Matsuoka H, Harada K, Mugishima G, Kameyama M:
　　TASK channels: channelopathies, trafficking, and receptor-mediated inhibition. 
　　Pflugers Arch, 2020 472(7):911-922

38   Matsuoka H, Pokorski M, Harada K, Yoshimura R, Inoue M:
　　Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 　　 Cells.
　　J Histochem Cytochem, 2020 68(10):679-690.

39   Harada K, Matsuoka H, Toyohira Y, Yanagawa Y, Inoue M:
　　Mechanisms for establishment of GABA signaling in adrenal medullary chromaffin cells. 
　　J Neurochem, 2021 158(2):153-168

40   Matsuoka H, Pokorski M, Takeda K, Okada Y, Harada K, Inoue M:
　　Expression of p11 and TASK1 Channels in Rat Carotid Body Glomus Cells Subjected to Chronic Intermittent Hypoxia.
　　J UOEH, 2022 44(3):249-255

41   Matsuoka H, Harada K, Sugawara A, Kim D, Inoue M: 
　　Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells. 
　　Acta Histochem, 2022 124(5):151898

42   Harada K, Matsuoka H, Inoue M: 
　　Immunocytochemistry of Acutely Isolated Adrenal Medullary Chromaffin Cells.
　　Methods Mol Biol, 2023 2565:35-4210

43   Kim D, Harada K, Inoue M: 
　　Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells. 
　　Biochem Biophys Res Commun, 2023 645:17-23

44   Harada K, Inoue M: 
　　Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca2+ Channels in Rat Adrenal Medullary Chromaffin Cells.
　　Acta Histochem Cytochem, 2023 56(4):67-75

45   Inoue M, Harada K:
　　Enhancement of muscarinic receptor-mediated excitation in spontaneously hypertensive rat adrenal medullary chromaffin cells. 
　　Auton Neurosci, 2023 248:103108

［文責： 第2生理 K. HARADA／ 更新日: 2023. 10. 17]