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分子生物学 研究業績

2020年

Hirata T, Arai Y, Yuasa S, Abe Y, Takayama M, Sasaki T, Kunitomi A, Inagaki H, Endo M,
Morinaga J, Yoshimura K, Adachi T, Oike Y, Takebayashi T, Okano H & Hirose N,
Associations of Cardiovascular Biomarkers and Plasma Albumin with Exceptional Survival to
the Highest Ages.
Nat Commun , 11:3820,2020

Osumi H, Horiguchi H, Kadomatsu T, Tashiro K, Morinaga J, Takahashi T, Ikeda K, Ito T, suzuki M,
Endo M, Oike Y: Tumor cell-derived angiopoietin-like protein 2 establishes a preference for
glycolytic metabolism in lung cancer cells. Cancer Sci , 111:1241-1253, 2020

2019年

Endo M : The Roles of ANGPTL Families in Cancer Progression. J UOEH , 41:317-325, 2019

Satou G, Maji D, Isamoto T, Oike Y, Endo M:
UV-B-activated B16 melanoma cells or HaCaT keratinocytes increase melanogenesis via ANGPTL2 induction, an activity antagonized by Chrysanthemum extract. Exp Dermatol, 28:152-160, 2019

Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y204204:
Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. Circ J , 83:368-378, 2019

Kurahashi R, Kadomatsu T, Baba M, Hara C, Itoh H, Miyata K, Endo M, Morinaga J, Terada K, Araki K, Eto M,Schmidt LS, Kamba T, Linehan WM, Oike Y:
MicroRNA- 204-5p:A novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.
Cnacer Sci , 110:1897-1908, 2019

2018年

Itoh H, Kadomatsu T, Tanoue H, Yugami M, Miyata K, Endo M, Morinaga J, Kobayashi E, Miyamoto T, Kurahashi R, Terada K, Mizuta H, Oike Y:
TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.
Oncogene 37:2903-2920, 2018

Takeuchi M, Doi T, Obayashi K, Hirai A, Yoneda K, Tanaka F, Iwai Y:
Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer.
Immunol Lett 196:155-160, 2018

Morinaga J*, Zhao J*, Endo M*, Kadomatsu T, Miyata K, Sugizaki T, Okadome Y, Tian Z, Horiguchi H, Miyashita K, Maruyama N, Mukoyama M, Oike Y (*First three authors are equal contribution):
Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.
PLoS One 13:e0193731, 2018

Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y:
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
J Biol Chem 293:1596-1609, 2018

Tian Z, Miyata K, Morinaga J, Horiguchi H, Kadomatsu T, Endo M, Zhao J, Zhu S, Sugizaki T, Sato M, Terada K, Okumura T, Murohara T, Oike Y:
Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction.
Circ J 82:437-447, 2018

Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y:
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Osteoarthr Cartil 26:108-117, 2018

2017年

Horiguchi H, Endo M*, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y (*corresponding author):
ANGPTL2 expression in intestinal stem cell niche controls epithelial regeneration and homeostasis.
EMBO J 36:409-424, 2017

Sugizaki T, Zhu S, Guo G, Matsumoto A, Zhao J, Endo M, Horiguchi H, Morinaga J, Tian Z, Kadomatsu T, Miyata K, Itoh H, Oike Y:
Treatment of diabetic mice with the S GLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.
NPJ Aging Mech Dis 3時12分, 2017

Oike Y, Tian Z, Miyata K, Morinaga J, Endo M, Kadomatsu T:
ANGPTL2: a new causal player in accelerating heart disease development in the aging.
Circ J 81:1379-1385, 2017

遠藤元誉, 尾池雄一:
ANGPTL2によるサルモネラ菌感染に対するマクロファージの活性化
臨床免疫・アレルギー科, 科学評論社, 67:471-476頁, 2017

2016年

Motokawa I, Endo M*, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H, Oike Y (*corresponding author):
Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.
Am J Physiol Lung Cell Mol Physiol 311: L704-L713, 2016

Yugami M, Odagiri H, Endo M*, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y (*corresponding author):
Mice deficient in Angptl2 show increased susceptibility to bacterial infection due to attenuated macrophage activity.
J Biol Chem 291:18843-18852, 2016

Doi T, Kwon HJ, Honda T, Sato H, Yoneda M, Kai C:
Measles virus induces persistent infection by autoregulation of viral replication.
Sci Rep 24;6:37163, 2016

Tanigawa H, Miyata K, Tian Z, Kadomatsu T, Aoi J, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, HATA A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y:
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci Rep 6:34690, 2016

Amadatu T, Morinaga J, Kawano T, Terada K, Kadomatsu T, Miyata K, Endo M, Kasamo D, Kuratsu J, Oike Y:
Macrophage-derived angiopoietin-like protein 2 exacerbates brain damage by accelerating acute inflammation after ischemia-reperfusion.
PLoS One 11:e0166285, 2016

Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y:
ANGPTL2 Activity in Cardiac Pathologies Accelerates Heart Failure by Perturbing Cardiac Function and Energy Metabolism.
Nat Commun 7:13016, 2016

Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T:
Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study.
Arterioscler Thromb Vasc Biol 36:1686-1691, 2016

Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y:
Angiopoietin-like Protein 2 is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.
J Biol Chem 291:7373-7385, 2016

Morinaga J, Kadomatsu T, Miyata K, Endo M, Terada K, Tian Z, Sugizaki T, Tanigawa H, Zhao J, Zhu S, Sato M, Araki K, Iyama K, Tomita K, Mukoyama M, Tomita K, Kitamura K, Oike Y:
ANGPTL2 increases renal fibrosis by accelerating TGF-β signaling in chronic kidney disease.
Kidney Int 89:327-341, 2016

遠藤元誉, 尾池雄一:
アンジオポエチン様因子
Thyroid Cancer Explore, メディカルレビュー社2時51分-56頁, 2016

更新日:2020年7月28日
文責:分子生物学