薬理学 研究業績
2024年
論文
Life Sci. 2024 Aug 15;351:122807. doi: 10.1016/j.lfs.2024.122807. Pubmed
Noma
T,
Yoshimoto
S,
Kamura
Y,
Arioka
M.
Predentin's
influence
on
clastic
cell
behavior
in
human
external
cervical
resorption:
evidence
from
a
case
study.
J
Dent
Sci.
2024
Jul;19(3):1840-1845.
doi:
10.1016/j.jds.2024.04.023
Pubmed
Kishigami
T,
Ishikane
S,
Arioka
M,
Igawa
K,
Nishimura
Y,
Takahashi-Yanaga
F.
2,5-Dimethyl-celecoxib
induces
early
termination
of
inflammatory
responses
by
transient
macrophage
accumulation
and
inhibits
the
progression
of
cardiac
remodeling
in
a
mouse
model
of
cryoinjury-induced
myocardial
infarction.
J
Pharmacol
Sci.
2024
Feb;154(2):97-107.
doi:
10.1016/j.jphs.2024.01.001.
Pubmed
2023年
論文
Arioka
M,
Seto-Tetsuo
F,
Inoue
T,
Miura
K,
Ishikane
S,
Igawa
K,
Tomooka
K,
Takahashi-Yanaga
F,
Sasaguri
T.
Differeniation-inducing
factor-1
reduces
lipopolysaccharide-induced
vascular
cell
adhesion
molecule-1
by
supressing
mTORC1-S6K
sugbakung
in
vascular
endotherial
cells.
Life
Sci.
2023
Dec
15;335:122278.
doi:
10.1016/j.lfs.2023.122278.
Pubmed
Ishikane
S,
Arioka
M,
Takahashi-Yanaga
F.
Promising
small
molecule
anti-fibrotic
agents:
newly
developed
or
repositioned
drugs
targeting
myofibroblast
transdifferentiation.
Biochemical
Pharmacology.
2023.
Aug;214:115663.
doi:
10.1016/j.bcp.2023.115663.
Pubmed.
Seto-Tetsuo
F, Arioka
M,
Miura
K,
Inoue
T,
Igawa
K,
Tomooka
K,
Sasaguri
T.
DIF-1
exhibits
anticancer
activity
in
breast
cancer
via
inhibition
of
CXCLs/CXCR2
axis-mediated
communication
between
cancer-associated
fibroblasts
and
cancer
cells.
International
Immunopharmacology. 2023
Apr;117:109913.
doi:
10.1016/j.intimp.2023.109913. Pubmed.
Inoue
T,
Miura
K,
Han
R,
Seto-Tetsuo
F, Arioka
M,
Igawa
K,
Tomooka
K,
Sasaguri
T.
Differentiation-Inducing
Factor
1
Activates
Cofilin
Through
Pyridoxal
Phosphatase
and
AMP-Activated
Protein
Kinase,
Resulting
in
Mitochondrial
Fission.
Journal
of
Pharmacological
Sciences. 2023
May;152(1):39-49.
doi:
10.1016/j.jphs.2023.02.009. Pubmed.
2022年
論文
Hirata
A, Ishikane
S,
Takahashi-Yanaga
F, Arioka
M, Okui
T, Nojiri
C, Sasaguri
T, Nakashima
N.
Increased
risk
of
metastasis
in
patients
with
incidental
use
of
renin-angiotensin
system
inhibitors:
a
retrospective
analysis
for
multiple
types
of
cancer
based
on
electronic
medical
records.
Hypertension
Research.
2022
Dec;45(12):1869-1881.
doi:
10.1038/s41440-022-01038-4. Pubmed.
Benjamin
R.
Coyac,
Benjamin
J.
Wolf,
Daniel
J.
Bahat,
Masaki
Arioka,
John
B.
Brunski,
Jill
A.
Helms
A
WNT
protein
therapeutic
accelerates
consolidation
of
a
bone
graft
substitute
in
a
pre-clinical
sinus
augmentation
model
.
J
Clin
Periodontol.
2022
Aug;49(8):782-798.
doi:
10.1111/jcpe.13674. Pubmed
Ikushima
E,
Ishikane
S, Kishigami
T, Matsunaga
H, Igawa
K, Tomooka
K,
Nishimura
Y, Takahashi-Yanaga
F.
2,5-Dimethylcelecoxib
attenuates
cardiac
fibrosis
caused
by
cryoinjury-induced
myocardial
infarction
by
suppressing
the
fibroblast-to-myofibroblast
transformation
via
inhibition
of
the
TGF-β
signaling
pathway.
Biochemical Pharmacology.
2022 Mar;197:114950. doi: 10.1016/j.bcp.2022.114950. Pubmed.
2021年
論文
Takiguchi
T,
Takahashi-Yanaga
F,
Ishikane
S,
Tetsuo
F,
Hosoda
H,
Arioka
M,
Kitazono
T,
Sasaguri
T.
Angiotensin
II
promotes
primary
tumor
growth
and
metastasis
formation
of
murine
TNBC
4T1
cells
through
the
fibroblasts
around
cancer
cells.
European
Journal
of
Pharmacology. 2021
Oct
15;909:174415. Pubmed.
Seto-Tetsuo
F,
Arioka
M,
Miura
K,
Inoue
T,
Igawa
K,
Tomooka
K,
Takahashi-Yanaga
F,
Sasaguri
T.
DIF-1
inhibits
growth
and
metastasis
of
triple-negative
breast
cancer
through
AMPK-mediated
inhibition
of
the
mTORC1-S6K
signaling
pathway.
Oncogene. 2021
Sep;40(37):5579-5589. Pubmed.
2020年
論文
Ishikane
S,
Ikushima
E,
Igawa
K,
Tomooka
K,
Takahashi-Yanaga
F.
Differentiation-inducing
factor-1
potentiates
adipogenic
differentiation
and
attenuates
the
osteogenic
osteogenic
differentiation
of
bone
marrow-derived
mesenchymal
stem
cells.
BBA
-
Molecular
Cell
Research.
2021
Feb.
1868(2):118909. Pubmed.
Yamamoto
M,
Takahashi-Yanaga
F,
Arioka
M,
Igawa
K,
Tomooka
K,
Yamaura
K,
Sasaguri
T.
Cardiac
and
renal
protective
effects
of
2,5-dimethylcelecoxib
in
angiotensin
II
and
high-salt-induced
hypertension
model
mice.
Journal
of
Hypertension.
2021
May.
39(5):892-903.
Pubmed.
Maeno
M,
Mizutani
T,
Tsuyoshi
H,
Yamada
S,
Ishikane
S,
Kawabe
S,
Nishimura
K,
Yamada
M,
Miyamoto
K,
Yoshida
Y.
Development
of
a
novel
and
rapid
measurement
system
for
growth
differentiation
factor-15,
progranulin,
and
osteopontin
in
uterine
sarcoma.
Endocrine
Journal.
2020
Jan;
67(1):91-94.
Pubmed.
2019年
論文
Tetsuo
F,
Arioka
M,
Miura
K,
Kai
M,
Kubo
M,
Igawa
K,
Tomooka
K,
Takahashi-Yanaga
F,
Nishimura
F,
Sasaguri
T.
DIF-1
suppresses
cyclin
D1-induced
cell
proliferation
of
MCF-7
breast
cancer
cells
by
inhibiting
S6K-mediated
STAT3
synthesis.
Cancer
Science.
2019
Dec;
110(12):3761-3772.
PubMed.
Morishige
S,
Takahashi-Yanaga
F,
Ishikane
S,
Arioka
M,
Igawa
K,
Kuroo
A,
Tomooka
K,
Shiose
A,
Sasaguri
T.
2,5-Dimethylcelecoxib
prevents
isoprenaline-induced
cardiomyocyte
hypertrophy
and
cardiac
fibroblast
activation
by
inhibiting
Akt-mediated
GSK-3
phosphorylation.
Biochemical
Pharmacology.
2019
June;
168:82-90. PubMed.
Arioka
M,
Takahashi–Yanaga
F.
Glycogen
Synthase
kinase-3
inhibitor
as
a
multi-targeting
anti-rheumatoid
drug.
Biochemical
Pharmacology.
2019
Jul;
165:
207-213. PubMed.
Yoshihara
T,
Zaitsu
M,
Shiraishi
F,
Arima
H,
Takahashi–Yanaga
F,
Arioka
M,
Kajioka
S,
Sasaguri
T.
Influence
of
genetic
polymorphisms
and
habitual
caffeine
intake
on
the
changes
in
blood
pressure,
pulse
rate,
and
calculation
speed
after
caffeine
intake:
A
prospective,
double
blind,
randomized
trial
in
healthy
volunteers.
Journal
of
Pharmacological
Sciences.
2019
Mar;
139(3):209-214.
PubMed.
2018年
論文
Takahashi–Yanaga
F.
Roles
of
glycogen
Synthase
kinase-3
(GSK-3)
in
cardiac
development
and
heart
disease.
J
UOEH.
2018;40(2):147-156. PubMed.
Ishikane
S,
Hosoda
H,
Nojiri
T,
Tokudome
T,
Mizutani
T,
Miura
K,
Akitake
Y,
Kimura
T,
Imamichi
Y,
Kawabe
S,
Toyohira
Y,
Yanagihara
N,
Takahashi–Yanaga
F,
Miyazato
M,
Miyamoto
K,
Kangawa
K.
Angiotensin
II
promotes
pulmonary
metastasis
of
melanoma
through
the
activation
of
adhesion
molecules
in
vascular
endothelial
cells.
Biochemical
Pharmacology.
2018
Apr
17;154:136-147.
PubMed.
Ishikane
S,
Takahashi-Yanaga
F.
The
role
of
angiotensin
II
in
cancer
metastasis:
Potential
of
renin-angiotensin
system
blockade
as
a
treatment
for
cancer
metastasis.
Biochemical
Pharmacology.
2018
Mar
10;151:96-103. PubMed.
著書
笹栗俊之,
宮田篤郎,
高橋富美他
ベッドサイドの薬理学
P.112-113.
P.311-322.
P.347-359
丸善出版2018.3
2017年
論文
Arioka
M,
Takahashi-Yanaga
F,
Tatsumoto
N,
Sasaguri
T.
Inorganic
phosphate-induced
impairment
of
osteoclast
cell-cell
fusion
by
the
inhibition
of
AP-1-mediated
DC-STAMP
expression
Biochem
Biophys
Res
Commun.
2017
Nov
4;493(1):9-13.
Egashira
I,
Takahashi-Yanaga
F,
Nishida
R,
Arioka
M,
Igawa
K,
Tomooka
K,
Nakatsu
Y,
Tsuzuki
T,
Nakabeppu
Y,
Kitazono
T,
Sasaguri
T.
Celecoxib
and
2,5-dimethylcelecoxib
inhibit
intestinal
cancer
growth
by
suppressing
the
Wnt/β-catenin
signaling
pathway.
Cancer
Science.
2017
Jan;108(1):108-115.
Nagano
A,
Arioka
M,
Takahashi-Yanaga
F,
Matsuzaki
E,
Sasaguri
T.
Celecoxib
inhibits
osteoblast
maturation
by
suppressing
the
expression
of
Wnt
target
genes.
Journal
of
Pharmacological
Sciences.
2017
Jan;133(1):18-24
Fujita
A,
Takahashi-Yanaga
F,
Morimoto
S,
Yoshihara
T,
Arioka
M,
Igawa
K,
Tomooka
K,
Hoka
S,
Sasaguri
T.
2,5-Dimethylcelecoxib
prevents
pressure-induced
left
ventricular
remodeling
through
GSK-3
activation.
Hypertension
Research.
2017
Feb;40(2):130-139.
Li
X,
Horishita
T,
Toyohira
Y,
Shao
H,
Bai
J,
Bo
H,
Song
X,
Ishikane
S,
Yoshinaga
Y,
Satoh
N,
Tsutsui
M,
Yanagihara
N.
Inhibitory
effects
of
pine
nodule
extract
and
its
component,
SJ-2,
on
acetylcholine-induced
catecholamine
secretion
and
synthesis
in
bovine
adrenal
medullary
cells.
Journal
of
Pharmacological
Sciences.
2017
Apr;133(4):268-275.
Arioka
M,
Takahashi-Yanaga
F,
Kubo
M,
Igawa
K,
Tomooka
K,
Sasaguri
T.
Anti-tumor
effects
of
differentiation-inducing
factor-1
in
malignant
melanoma:
GSK-3-mediated
inhibition
of
cell
proliferation
and
GSK-3-independent
suppression
of
cell
migration
and
invasion.
Biochemical
Pharmacology.
2017
Aug
15;138:31-48.
2016年
論文
Mohamed
RM,
Morimoto
S,
Ibrahim
IA,
Zhan
DY,
Du
CK,
Arioka
M,
Yoshihara
T,
Takahashi-Yanaga
F,
Sasaguri
T.
GSK-3β
heterozygous
knockout
is
cardioprotective
in
a
knockin
mouse
model
of
familial
dilated
cardiomyopathy.
American
Journal
of
Physiology
Heart
and
Circulatory
Physiology.
2016
Jun
1;310(11):H1808-15.
Noma
T,
Takahashi-Yanaga
F,
Arioka
M,
Mori
Y,
Sasaguri
T.
Inhibition
of
GSK-3
reduces
prostaglandin
E2
production
by
decreasing
the
expression
levels
of
COX-2
and
mPGES-1
in
monocyte/macrophage
lineage
cells.
Biochemical
Pharmacology.
2016
Sep
15;116:120-9.
Hashimoto
Y,
Kobayashi
M,
Matsuzaki
E,
Higashi
K,
Takahashi-Yanaga
F,
Takano
A,
Hirata
M,
Nishimura
F.
Sphingosine-1-phosphate-enhanced
Wnt5a
promotes
osteogenic
differentiation
in
C3H10T1/2
cells.
Cell
Biology
International.
2016
Oct;40(10):1129-36.
Tatsumoto
N,
Arioka
M,
Yamada
S,
Takahashi-Yanaga
F,
Tokumoto
M,
Tsuruya
K,
Kitazono
T,
Sasaguri
T.
Inhibition
of
GSK-3β
increases
trabecular
bone
volume
but
not
cortical
bone
volume
in
adenine-induced
uremic
mice
with
severe
hyperparathyroidism.
Physiological
Reports.
2016
Nov;4(21).
Higashi
K,
Matsuzaki
E,
Hashimoto
Y,
Takahashi-Yanaga
F,
Takano
A,
Anan
H,
Hirata
M,
Nishimura
F.
Sphingosine-1-phosphate/S1PR2-mediated
signaling
triggers
Smad1/5/8
phosphorylation
and
thereby
induces
Runx2
expression
in
osteoblasts.
Bone.
2016
Dec;93:1-11.
吉原
達也,
白源
正成,
白石
富美恵,
有馬
久富,
内丸
比奈子,
松木
俊二,
高橋
富美,
入江
伸,
笹栗
俊之
アトルバスタチンの硝酸薬投与後血管内皮機能改善効果に及ぼすALDH2*2の影響
臨床薬理の進歩
37号
Page109-119(2016.06)
柳原
延章,
石
明寛,
佐藤
教昭,
後藤
幸生
更年期障害と自律神経バランス
更年期と加齢のヘルスケア
15巻2号
Page399-406(2016.12)