薬理学 研究業績

2025年

論文

Tanaka M, Ishikane S, Back DB, Licastro E, Zhang F, Park JH, Esposito E, Pignataro G, Nakano T, Nakamura Y, Hayakawa K.
Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis.
J Cereb Blood Flow Metab. 2025 Mar 13; 71678X251326871. doi: 10.1177/0271678X251326871. Pubmed

2024年

論文

Arioka M, Yi W, Igawa K, Ishikane S, Takahashi-Yanaga F.
Differentiation-inducing factor-1 inhibits EMT by proteasomal degradation of TAZ and YAP in cervical and colon cancer cell lines.
Eur J Pharmacol. 2025 Jan 15;987:177184. doi: 10.1016/j.ejphar.2024.177184.  Pubmed

Arioka M, Miura K, Han R, Igawa K, Takahashi-Yanaga F, Sasaguri T.
Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission.
Life Sci. 2024 Aug 15;351:122807. doi: 10.1016/j.lfs.2024.122807. Pubmed

Noma T, Yoshimoto S, Kamura Y, Arioka M.
Predentin's influence on clastic cell behavior in human external cervical resorption: evidence from a case study.
J Dent Sci. 2024 Jul;19(3):1840-1845. doi: 10.1016/j.jds.2024.04.023  Pubmed

Kishigami T, Ishikane S, Arioka M, Igawa K, Nishimura Y, Takahashi-Yanaga F.
2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction.
J Pharmacol Sci. 2024 Feb;154(2):97-107. doi: 10.1016/j.jphs.2024.01.001.  Pubmed

2023年

論文

Arioka M, Seto-Tetsuo F, Inoue T, Miura K, Ishikane S, Igawa K, Tomooka K, Takahashi-Yanaga F, Sasaguri T.
Differeniation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by supressing mTORC1-S6K sugbakung in vascular endotherial cells.
Life Sci. 2023 Dec 15;335:122278. doi: 10.1016/j.lfs.2023.122278.  Pubmed

Ishikane S, Arioka M, Takahashi-Yanaga F. 
Promising small molecule anti-fibrotic agents: newly developed or repositioned drugs targeting myofibroblast transdifferentiation.
Biochemical Pharmacology. 2023.  Aug;214:115663. doi: 10.1016/j.bcp.2023.115663.  Pubmed.

Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Sasaguri T. 
DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.
International Immunopharmacology. 2023 Apr;117:109913. doi: 10.1016/j.intimp.2023.109913. Pubmed.

Inoue T, Miura K, Han R, Seto-Tetsuo F, Arioka M, Igawa K, Tomooka K, Sasaguri T. 
Differentiation-Inducing Factor 1 Activates Cofilin Through Pyridoxal Phosphatase and AMP-Activated Protein Kinase, Resulting in Mitochondrial Fission. 
Journal of Pharmacological Sciences. 2023 May;152(1):39-49. doi: 10.1016/j.jphs.2023.02.009. Pubmed.

2022年

論文

Hirata A, Ishikane S, Takahashi-Yanaga F, Arioka M, Okui T, Nojiri C, Sasaguri T, Nakashima N.
Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records.
Hypertension Research. 2022 Dec;45(12):1869-1881. doi: 10.1038/s41440-022-01038-4. Pubmed.

Benjamin R. Coyac, Benjamin J. Wolf, Daniel J. Bahat, Masaki Arioka, John B. Brunski, Jill A. Helms 
A WNT protein therapeutic accelerates consolidation of a bone graft substitute in a pre-clinical sinus augmentation model .
J Clin Periodontol. 2022 Aug;49(8):782-798.  doi: 10.1111/jcpe.13674. Pubmed

Ikushima E,  Ishikane S, Kishigami T, Matsunaga H, Igawa K, Tomooka K, Nishimura Y, Takahashi-Yanaga F.
2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway.
Biochemical Pharmacology. 2022 Mar;197:114950. doi: 10.1016/j.bcp.2022.114950. Pubmed.

2021年

論文

Takiguchi T,  Takahashi-Yanaga F, Ishikane S, Tetsuo F, Hosoda H, Arioka M, Kitazono T, Sasaguri T.
Angiotensin II promotes primary tumor growth and metastasis formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells.
European Journal of Pharmacology. 2021 Oct 15;909:174415.  Pubmed.

Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Takahashi-Yanaga F, Sasaguri T.
DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway.
Oncogene. 2021 Sep;40(37):5579-5589. Pubmed.

2020年

論文

Ishikane S, Ikushima E, Igawa K, Tomooka K, Takahashi-Yanaga F.
Differentiation-inducing factor-1 potentiates adipogenic differentiation and attenuates the osteogenic osteogenic differentiation of bone marrow-derived mesenchymal stem cells.
BBA - Molecular Cell Research. 2021 Feb. 1868(2):118909. Pubmed.

Yamamoto M, Takahashi-Yanaga F, Arioka M, Igawa K, Tomooka K, Yamaura K, Sasaguri T.
Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice.
Journal of Hypertension. 2021 May. 39(5):892-903.  Pubmed.

Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, Nishimura K, Yamada M, Miyamoto K, Yoshida Y.
Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma.
Endocrine Journal. 2020 Jan; 67(1):91-94. Pubmed.

2019年

論文

Tetsuo F, Arioka M, Miura K, Kai M, Kubo M, Igawa K, Tomooka K, Takahashi-Yanaga F, Nishimura F, Sasaguri T.
DIF-1 suppresses cyclin D1-induced cell proliferation of MCF-7 breast cancer cells by inhibiting S6K-mediated STAT3 synthesis.
Cancer Science. 2019 Dec; 110(12):3761-3772. PubMed.

Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T.
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Biochemical Pharmacology. 2019 June; 168:82-90. PubMed.

Arioka M, Takahashi–Yanaga F.
Glycogen Synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.
Biochemical Pharmacology. 2019 Jul; 165: 207-213. PubMed.

Yoshihara T, Zaitsu M, Shiraishi F, Arima H, Takahashi–Yanaga F, Arioka M, Kajioka S, Sasaguri T.
Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers.
Journal of Pharmacological Sciences. 2019 Mar; 139(3):209-214. PubMed.

2018年

論文

Takahashi–Yanaga F.
Roles of glycogen Synthase kinase-3 (GSK-3) in cardiac development and heart disease.
J UOEH. 2018;40(2):147-156. PubMed.

Ishikane S, Hosoda H, Nojiri T, Tokudome T, Mizutani T, Miura K, Akitake Y, Kimura T, Imamichi Y, Kawabe S, Toyohira Y, Yanagihara N, Takahashi–Yanaga F, Miyazato M, Miyamoto K, Kangawa K.
Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells.
Biochemical Pharmacology. 2018 Apr 17;154:136-147. PubMed.

Ishikane S, Takahashi-Yanaga F.
The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis.
Biochemical Pharmacology. 2018 Mar 10;151:96-103. PubMed.

著書

笹栗俊之, 宮田篤郎, 高橋富美他
ベッドサイドの薬理学 P.112-113. P.311-322. P.347-359 丸善出版2018.3

2017年

論文

Arioka M, Takahashi-Yanaga F, Tatsumoto N, Sasaguri T.
Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression
Biochem Biophys Res Commun. 2017 Nov 4;493(1):9-13.

Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T.
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway.
Cancer Science. 2017 Jan;108(1):108-115.

Nagano A, Arioka M, Takahashi-Yanaga F, Matsuzaki E, Sasaguri T.
Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes.
Journal of Pharmacological Sciences.  2017 Jan;133(1):18-24

Fujita A, Takahashi-Yanaga F, Morimoto S, Yoshihara T, Arioka M, Igawa K, Tomooka K, Hoka S, Sasaguri T.
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Hypertension Research. 2017 Feb;40(2):130-139.

Li X, Horishita T, Toyohira Y, Shao H, Bai J, Bo H, Song X, Ishikane S, Yoshinaga Y, Satoh N, Tsutsui M, Yanagihara N.
Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells.
Journal of Pharmacological Sciences.  2017 Apr;133(4):268-275.

Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Tomooka K, Sasaguri T.
Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
Biochemical Pharmacology. 2017 Aug 15;138:31-48.

2016年

論文

Mohamed RM, Morimoto S, Ibrahim IA, Zhan DY, Du CK, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T.
GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy.
American Journal of Physiology Heart and Circulatory Physiology. 2016 Jun 1;310(11):H1808-15.

Noma T, Takahashi-Yanaga F, Arioka M, Mori Y, Sasaguri T.
Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells.
Biochemical Pharmacology. 2016 Sep 15;116:120-9.

Hashimoto Y, Kobayashi M, Matsuzaki E, Higashi K, Takahashi-Yanaga F, Takano A, Hirata M, Nishimura F.
Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells.
Cell Biology International. 2016 Oct;40(10):1129-36.

Tatsumoto N, Arioka M, Yamada S, Takahashi-Yanaga F, Tokumoto M, Tsuruya K, Kitazono T, Sasaguri T.
Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism.
Physiological Reports. 2016 Nov;4(21).

Higashi K, Matsuzaki E, Hashimoto Y, Takahashi-Yanaga F, Takano A, Anan H, Hirata M, Nishimura F.
Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.
Bone. 2016 Dec;93:1-11.

吉原 達也, 白源 正成, 白石 富美恵, 有馬 久富, 内丸 比奈子, 松木 俊二, 高橋 富美, 入江 伸, 笹栗 俊之
アトルバスタチンの硝酸薬投与後血管内皮機能改善効果に及ぼすALDH2*2の影響
臨床薬理の進歩 37号 Page109-119(2016.06)

柳原 延章, 石 明寛, 佐藤 教昭, 後藤 幸生
更年期障害と自律神経バランス
更年期と加齢のヘルスケア 15巻2号 Page399-406(2016.12)