救急・集中治療医学 研究内容

1. 敗血症の病態生理と治療

　基礎、臨床を通じて敗血症や重症感染症の病態生理の解明と治療に関する研究を行っています。また公衆衛生学との共同研究も行っており、DPCデータを用いた疫学研究も行っています。

[発表論文]

1. Ogata M, Yoshida S, Kamochi M, Shigematsu A, Mizuguchi Y：Enhancement of lipopolysaccharide-induced tumor necrosis factor  production by carrageenan pretreatment in mice.　Infection and Immunity 59:679-683，1991
2. Kamochi M, Ogata M, Yoshida S, Matsumoto T, Kubota E, Mizuguchi Y, Shigematsu A: Priming effect of dextran sulfates on lipopolysaccharide-induced tumor necrosis factor production in mice. FEMS Microbiology Immunology 　89:175-181, 1992
3. Ogata M, Matsumoto T, Kamochi M, Yoshida S： Protective effects of a leukotrien inhibitor and a leukotriene antagonist on  endotoxin-induced mortality in carrageenan-pretreated mice. Infection and Immunity 60:2432-2437，1992
4. Kamochi M, Ogata M, Yoshida S, Matsumoto T, Kubota E, Mizuguchi Y, Shigematsu A.：Dextran sulphate enhancement of  lipopolysaccharide-induced tumor necrosisfactor-a production by murine peritoneal macrophages: Correlation with macrophage blockade. FEMS Immunology and Medical Microbiology.7:153-160，1993
5. Ogata M, Matsumoto T, Koga K, Takenaka I, Kamochi M, Sata T, Yoshida S,Shigematsu A： An antagonist of platelet-activating factor suppresses endotoxin-induced tumor necrosis factor and mortality in mice pretreated with carrageenan.Infection and Immunity 61:699-704,1993
6. Kamochi M, Kamochi F, Kim YB, Sawh S, Sanders J, Sarembock I, Green S, Young JS, Ley K, Fu SM, Rose Jr. CE： P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver.  Am. J. Physiol. 277 (Lung Cell Mol Physiol. 21): L310 -L319，1999
7. Uriu K, Osajima A, Kamochi M, Watanabe H, Aibara K, Kaizu K：The severity of hyperdynamic circulation may predict the effects of  direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber in  patients with gram-negative septic shock. Therapeutic Apheresis  5(1): 25-30，2001
8. Uriu K, Osajima A, Hiroshige K, Watanabe H, Aibara K, Inada Y, Segawa K, Anai H, Takagi I, Ito A, Kamochi M, Kaizu K.： Endotoxin removal by direct hemoperfusion with an adsorbent column using polymyxin B-immobilized fiber ameliorates systemic circulatory disturbance in patients with septic shock. Am J Kidney Dis. 39(5):937-47，2002
9. Kamochi M, Aibara K, Nakata K, Murakami M, Nandate K, Sakamoto H, Sata T,Shigematsu A： Profound ionized hypomagnesemia induced by therapeutic plasma exchange in liver failure patients. Transfusion 42:1598-1602，2002
10. Harayana N, Nihei S, Nagata K, Isa Y, Goto K, Aibara K, Kamochi M, Sata T. Comparison of nifekalant and amiodarone for resuscitation of out-of- hospital cardiopulmonary arrest resulting from shock-resistant ventricular fibrillation. J Anesth. 28(4):587-92, 2014
11. Nihei S, Arai H, Uchida T, Kanazawa A, Endo T, Otsuji K, Harayama N, Aibara  K, Kamochi M. Usefulness of Fibrinogen/Fibrin Degradation Products Value in Differential Diagnosis Between Acute Ischemic Stroke and Acute Aortic Disease. J UOEH 40:139-145, 2018
12. Otsuji K, Fukuda K, Ogawa M, Fujino Y, Kamochi M and Saito: Dynamics of microbiota during mechanical ventilation in aspiration pneumonia. BMC pulmonary medicine 23;19(1):260. doi: 10.1186/s12890-019-1021-5. 2019
13. Matsuo M, Muramatsu K, Matsuda S, Fushimi K, Kaizuka Y, Kamochi M  Age- dependent influence of premorbid underweight status on mortality in severe burn patients: An administrative database study. Burns 47:1314-1321, 2021
    
    

2. 救急医療を産業医学的観点から見つめ直す

　産業医科大学は全国で唯一、労働環境や労働者の健康の関する分野での研究、教育を行うことを目的として設立された大学です。救急医療における労働環境や労働条件に関して多くの調査を行い、その改善を図るべく、産業生態科学研究所などとも連携し研究を行っております。最近では医療従事者の水晶体への被曝量の調査と防護具の研究を行い成果を得ています。

[発表論文]

1. Nagamoto K, Moritake K, Nakagami K, Morota K, Matsuzaki S, Nihei N, Kamochi M,Kunugita N. Occupational radiation dose to the lens of the eye of medical staff who assist in diagnostic CT scans. Heliyon2021,.2021.e06063
2. Nagamoto, Keisuke; Watanabe, Ryo; Kawachino, Tomonori; Ohishi, Yoshitaka; Yamamoto, Aina; Moritake, Takashi; Nihei, Shun-ichi; Kamachi, Masayuki; Kunugita, Naoki.　Contribution of organ-based tube current modulation to the reduction of lens exposure dose in head 4D-CT imaging: A phantom study Radiat Prot Dosimetry. 2022 ((in press)