生化学 研究業績

日笠　弘基

原著論文

Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Mak TW, Kiyono T, Katabuchi H, Tashiro H. and Suzuki A., "Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice."Cancer Sci, 111(10) 3576-3587 (2020)

Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T. and Suzuki A., "YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma",Sci Adv,6(12):eaay3324 (2020)

Kitajima S, Lee KL, Hikasa H., Sun W, Huang R YJ, Yang H, Matsunaga S, Yamaguchi T, Araki M, Kato H and Poellinger L.,“Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells” Oncotarget, 8 (70):114481-114494 (2017)

Hikasa H., Sekido Y. and Suzuki A., “Merlin/NF2-Lin28B-let7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent”, Cell Reports, 14(12) pp2950-61 (2016)

Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A., “Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice”, PNAS, 113(1) E71-80 (2015)

Hikasa, H. and Sokol, S. Y., “Wnt signaling in vertebrate axis specification”, Cold Spring Harbor Perspective in Biology, 5(1) pp197-216(2013)

Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S.O., Dong, Y., Tokuda, M., Morikawa, T., Hikasa, H., Eggenschwiler, J., Yabuta, N., Nojima, H., Nakagawa, K., Hata, Y., Nishina, H., Mimori, K., Mori, M., Sasaki, T., Mak, T.W., Nakano, T., Itami, S., Suzuki, A., “Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice”, J., Clin.,Invest., 122(12) pp4505-4518 (2012)

Sasaki, M., Kawahara, K., Nishio, M., Mimori, K., Kogo, R., Hamada, K., Itoh, B., Wang, J., Komatsu, Y., Yang, Y.R., Hikasa, H., Horie, Y., Yamashita, T., Kamijo, T., Zhang, Y., Zhu, Y., Prives, C., Nakano, T., Mak, T.W., Sasaki, T., Maehama, T., Mori, M., Suzuki, A., “Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11”, Nat. Med., 17 (8) pp944-951 (2011)

Hikasa, H. and Sokol, S. Y., “Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2”, J Biol. Chem., 286(14), pp12093-12100 (2011)

Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W. and Sokol S. Y., “Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification”, Dev. Cell, 295, pp26-39 (2010)

著書

Hikasa, H. and Sokol, S. Y., “Wnt signaling”（Section II Development,） Nusse, R., He, X., and van Amerongen, R., eds., Cold Spring Harbor Press, pp197-216 (2013)

知財関連

がん遺伝子産物YAP1/TAZ機能調節剤　（2017）（産業財産権、特願2017-218926）
イベルメクチン又はミルベマイシンDを有効成分として含む抗癌剤(2014)(産業財産権、特願2014-228901)

[文責：生化学　　更新日：2021.8.24]