生化学 研究業績

日笠　弘基

原著論文

Hikasa H, Kawahara K, Inui M, Yasuki Y, Yamashita K, Otsubo K, Kitajima S, Nishio M, Arima K, Endo M, Taira M, Suzuki A.,"A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells."Cancer Science, http://doi.org/10.1111/cas.16316 (2024)

Shiraishi Y, Maehama T, Nishio M, Otani J, Hikasa H, Mak TW, Sasaki T, Honma T, Kondoh Y, Osada H, Yoshida M, Fujisawa M. and Suzuki A., " N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ."Genes Cell, 27(10) 602-612 (2022)

Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A. "Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation." Cancer Sci, 112(10) 4303-16 (2021)

Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Mak TW, Kiyono T, Katabuchi H, Tashiro H. and Suzuki A., "Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice."Cancer Sci, 111(10) 3576-3587 (2020)

Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T. and Suzuki A., "YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma",Sci Adv,6(12):eaay3324 (2020)

Kitajima S, Lee KL, Hikasa H., Sun W, Huang R YJ, Yang H, Matsunaga S, Yamaguchi T, Araki M, Kato H and Poellinger L.,“Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells” Oncotarget, 8 (70):114481-114494 (2017)

Hikasa H., Sekido Y. and Suzuki A., “Merlin/NF2-Lin28B-let7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent”, Cell Reports, 14(12) pp2950-61 (2016)

Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A., “Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice”, PNAS, 113(1) E71-80 (2015)

Hikasa, H. and Sokol, S. Y., “Wnt signaling in vertebrate axis specification”, Cold Spring Harbor Perspective in Biology, 5(1) pp197-216(2013)

Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S.O., Dong, Y., Tokuda, M., Morikawa, T., Hikasa, H., Eggenschwiler, J., Yabuta, N., Nojima, H., Nakagawa, K., Hata, Y., Nishina, H., Mimori, K., Mori, M., Sasaki, T., Mak, T.W., Nakano, T., Itami, S., Suzuki, A., “Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice”, J., Clin.,Invest., 122(12) pp4505-4518 (2012)

Sasaki, M., Kawahara, K., Nishio, M., Mimori, K., Kogo, R., Hamada, K., Itoh, B., Wang, J., Komatsu, Y., Yang, Y.R., Hikasa, H., Horie, Y., Yamashita, T., Kamijo, T., Zhang, Y., Zhu, Y., Prives, C., Nakano, T., Mak, T.W., Sasaki, T., Maehama, T., Mori, M., Suzuki, A., “Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11”, Nat. Med., 17 (8) pp944-951 (2011)

Hikasa, H. and Sokol, S. Y., “Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2”, J Biol. Chem., 286(14), pp12093-12100 (2011)

Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W. and Sokol S. Y., “Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification”, Dev. Cell, 295, pp26-39 (2010)

著書

Hikasa, H. and Sokol, S. Y., “Wnt signaling”（Section II Development,） Nusse, R., He, X., and van Amerongen, R., eds., Cold Spring Harbor Press, pp197-216 (2013)

知財関連

特願2019-207336:Wnt/β-カテニン経路の活性化亢進作用を有するタンパク質

特願2017-218926:がん遺伝子産物YAP1/TAZ機能調節剤

特願2014-228901:イベルメクチン又はミルベマイシンDを有効成分として含む抗癌剤

[文責：生化学　　更新日：2024.8.27]