生体物質化学 研究業績

Tatsuya Kida , Nobuaki Takahashi , Masayuki X Mori , Jiacheng H Sun , Hideto Oota , Kosuke Nishino , Takashi Okauchi , Yuta Ochi , Daisuke Kano , Ukihide Tateishi , Yasuyoshi Watanabe , Yilong Cui , Yasuo Mori , Hisashi Doi 

N-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV1

RSC Med Chem. 2022 ;13(10):1197-1204.doi: 10.1039/d2md00158f. 

Masayuki X Mori , Ryo Okada , Reiko Sakaguchi , Hideharu Hase , Yuko Imai , Onur K Polat , Satoru G Itoh , Hisashi Okumura , Yasuo Mori , Yasushi Okamura , Ryuji Inoue

Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation

Sci Rep.2022 24;12(1):10766.doi: 10.1038/s41598-022-14766-x.

Tajima S, Nakata E, Sakaguchi R, Saimura M, Mori Y, Morii T.

A two-step screening to optimize the signal response of an auto-fluorescent protein-based biosensor.

RSC Adv., 12, 15407-15419 (2022). doi: 10.1039/d2ra02226e.

Carné-Sánchez A, Ikemura S, Sakaguchi R, Craig GA, Furukawa S.

Photoactive carbon monoxide-releasing coordination polymer particles.

Chem Commun., 58, 9894-9897 (2022). doi: 10.1039/d2cc03907a

Narazaki A, Shimizu R, Yoshihara T, Kikuta J, Sakaguchi R, Tobita S, Mori Y, Ishii M, Nishikawa K.

Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy.

Sci Rep, 12, 3497 (2022). DOI: 10.1038/s41598-022-07521-9.

Murakami A, Nagao K, Sakaguchi R, Kida K, Hara Y, Mori Y, Okabe K, Harada Y, Umeda M.

Cell-autonomous control of intracellular temperature by unsaturation of phospholipid acyl chains.

Cell Rep, 38, 110487 (2022). doi: 10.1016/j.celrep.2022.110487.

Hamada S, Masson E, Chen JM, Sakaguchi R, Rebours V, Buscail L, Matsumoto R, Tanaka Y, Kikuta K, Kataoka F, Sasaki A, Le Rhun M, Audin H, Lachaux A, Caumont B, Lorenzo D, Billiemaz K, Besnard R, Koch S, Lamireau T, De Koninck X; GREPAN (Genetic REsearch on PANcreatitis) Study Group, Génin E, Cooper DN, Mori Y, Masamune A, Férec C.

Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis.

Human Mutation, 43, 228-239 (2022). DOI: 10.1002/humu.24315

L Marongiu, F Mingozzi, C Cigni, R Marzi, M Di Gioia, M Garrè, D Parazzoli, L Sironi, M Collini, R Sakaguchi, T Morii, M Crosti, M Moro, S Schurmans, T Catelani, R Rotem, M Colombo, S Shears, D Prosperi, I Zanoni, F Granucci.

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.

Sci Signal, 14, eaaw2120 (2021).

K Nishikawa, S Seno, T Yoshihara, A Narazaki, Y Sugiura, R Shimizu, J Kikuta, R Sakaguchi, N Suzuki, N Takeda, H Semba, M Yamamoto, D Okuzaki, D Motooka, Y Kobayashi, M Suematsu, H Koseki, H Matsuda, M Yamamoto, S Tobita, Y Mori, M Ishii.

Osteoclasts adapt to physioxia perturbation through DNA demethylation.

EMBO Rep, e53035 (2021)

坂口 怜子, 金岡 英徳, 清中 茂樹.

タンパク質温度センサーを利用した細胞内温度計測

Netsu Sokutei, 48, 152-158 (2021).

Masamune A, Kotani H, Sörgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, Kakuta Y, Niihori T, Funayama R, Shirota M, Hirano T, Kawamoto T, Hosokoshi A, Kume K, Unger L, Ewers M, Laumen H, Bugert P, Mori MX, Tsvilovskyy V, Weißgerber P, Kriebs U, Fecher-Trost C, Freichel M, Diakopoulos KN, Berninger A, Lesina M, Ishii K, Itoi T, Ikeura T, Okazaki K, Kaune T, Rosendahl J, Nagasaki M, Uezono Y, Algül H, Nakayama K, Matsubara Y, Aoki Y, Férec C, Mori Y, Witt H, Shimosegawa T.

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.

Gastroenterology. 2020 ;158(6):1626-1641.e8. doi: 10.1053/j.gastro.2020.01.005.

Kawanabe A, Mizutani N, Polat OK, Yonezawa T, Kawai T, Mori MX, Okamura Y.

Engineering an enhanced voltage-sensing phosphatase.

J Gen Physiol. 2020 4;152(5):e201912491. doi: 10.1085/jgp.201912491

Jouraku A, Kuwazaki S, Miyamoto K, Uchiyama M, Kurokawa T, Mori E, Mori MX, Mori Y, Sonoda S.

Ryanodine receptor mutations (G4946E and I4790K) differentially responsible for diamide insecticide resistance in diamondback moth, Plutella xylostella L.

Insect Biochem Mol Biol. 2020 ;118:103308. doi: 10.1016/j.ibmb.2019.103308.

坂口 怜子:

細胞内温度センサーの種類と特徴.

実験医学 38, 1491-1494 (2020)

 Tachizaki T, Sakaguchi R, Terada S, Kamei K, Hirori H:

Terahertz pulse-altered gene networks in human induced pluripotent stem cells.

Optics Letters, 45, 6078-6081 (2020).

Uchiyama M, Nakao A, Kurita Y, Fukushi I, Takeda K, Numata T, Tran HN, Sawamura S, Ebert M, Kurokawa T, Sakaguchi R, Stokes A, Takahashi N, Okada Y, Mori Y:

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.

Curr Biol, 30, 3378-3396 (2020).

Tajima S, Nakata E, Sakaguchi R, Saimura M, Mori Y, Morii T:

Fluorescence detection of the nitric oxide-induced structural change at the putative nitric oxide sensing segment of TRPC5.

Bioorg Med Chem, 28, 115430 (2020).

Polat OK, Uno M, Maruyama T, Tran HN, Imamura K, Wong CF, Sakaguchi R, Ariyoshi M, Itsuki K, Ichikawa J, Morii T, Shirakawa M, Inoue R, Asanuma K, Reiser J, Tochio H, Mori Y, Mori MX:

Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes. J Am Soc Nephrol, 30, 1587-1603 (2019).

Sakaguchi R, Mori Y:

Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status.

Free Radic Biol Med. 146, 47-57 (2019).

Yamazaki D, Hasegawa A, Funato Y, Tran HN, Mori MX, Mori Y, Sato T, Miki H.

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia. Oncogene. doi: 10.1038/s41388-019-0682-0, 2019

Ohara-Imaizumi M, Aoyagi K, Yamauchi H, Yoshida M, Mori MX, Hida Y, Tran HN, Ohkura M, Abe M, Akimoto Y, Nakamichi Y, Nishiwaki C, Kawakami H, Hara K, Sakimura K, Nagamatsu S, Mori Y, Nakai J, Kakei M, Ohtsuka T.

ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic βCells. 

Cell Rep.; 26(5):1213-1226.e7, 2019

Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H:

TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development. Sci Signal, 12, eaaw4847 (2019).

Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M.

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.

Nat Commun. ; 9(1):2049, 2018.

【2018年以前に発表のものより抜粋】

Minobe E, Mori MX, Kameyama M:

Calmodulin and ATP support activity of the CaV1.2 channel through dynamic interactions with the channel.

J Physiol ; 595(8): 2465-77, 2017.

Hu Y, Duan Y, Takeuchi A, Hai-Kurahara L, Ichikawa J, Hiraishi K, Numata T, Ohara H, Iribe G, Nakaya M, Mori MX, Matsuoka S, Ma G, Inoue R:

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches.

Cardiovasc Res ; 113(10): 1243-55, 2017.

Hirano M, Takada Y, Wong CF, Yamaguchi K, Kotani H, Kurokawa T, Mori MX, Snutch TP, Ronjat M, De Waard M, Mori Y:

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 alpha1 subunits are differentially regulated by Rab3-interacting molecule proteins.

J Biol Chem ; 292(22):9365-81, 2017

Christian T‡, Sakaguchi R‡, Perlinska AP‡, Lahoud G, Ito T, Taylor EA, Yokoyama S, Sulkowska JI, and Hou YM: Methyl transfer by substrate signaling from a knotted protein fold.

Nat Struct Mol Biol, 10, 941-48 (2016). ‡Equal contribution.

Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y:

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.

Mol Pharmacol ; 89(3):348-63, 2016 

Sakaguchi R, Tainaka K, Shimada N, Nakano S, Inoue M, Kiyonaka S, Mori Y, and Morii T:

An in vivo fluorescent sensor reveals intracellular Ins(1,3,4,5)P4 dynamics in single cells.

Angew Chem Int Ed, 49, 2150-53 (2010).

Mori MX, Vander Kooi CW, Leahy DJ, Yue DT:

Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+.

Structure ; 16(4):607-20, 2008.

Mori MX, Erickson MG, Yue DT.

 Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels.

Science ; 304(5669):432-5, 2004.

Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH:

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

Molecular Psychiatry; 8(2):186-94,2003.

Erickson MG, Liang HY, Mori MX, Yue DT:

FRET two-hybrid mapping reveals function and location of L-type Ca2+ channel CaM preassociation.

Neuron ; 39(1):97-107, 2003.

Mori M, Konno T, Ozawa T, Murata M, Imoto K, Nagayama K:

Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin

Biochemistry ; 39(6):1316-23, 2000.